Cerebral Energy Metabolism in Geriatric Bipolar Depression

老年双相抑郁症的大脑能量代谢

• 批准号: 8424297
• 负责人: Brent Peter Forester
• 金额: $ 17.94万
• 依托单位: MCLEAN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2014-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8424297
• 关键词: Aftercare; Age; Aging; Aging-Related Process; Animals; Anterior; Area; Belief; Biochemical; Biochemical Markers; Biometry; Bipolar Depression; Bipolar Disorder; Brain; Brain imaging; Brain-Derived Neurotrophic Factor; Cerebrum; Chronic; Clinical; Clinical Pharmacology; Clinical Skills; Clinical Trials; Collaborations; Complex; Cross-Sectional Studies; Data; Defect; Dementia; Development; Diagnosis; Diagnostic; Diagnostic Procedure; Elderly; Energy Metabolism; Evaluation; Functional disorder; Future; Genes; Glutamates; Glutamine; Goals; Health; Health Services; Health system; Healthcare; Hospitals; Image; Imaging Techniques; Imaging technology; Individual; Institutes; Interview; Laboratories; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Measures; Mentors; Montgomery and Asberg depression rating scale; Moods; Morphologic artifacts; N-acetylaspartate; Neuropsychological Tests; Occipital lobe; Pathology; Patients; Performance; Pharmaceutical Preparations; Phase; Protons; Psychotic Mood Disorders; Public Health; Recording of previous events; Reporting; Research; Research Personnel; Scanning; Semantics; Severities; Site; Sorting - Cell Movement; Structure; Symptoms; Techniques; Testing; Therapeutic; Therapeutic Intervention; Training; Wisconsin; burnout; career; cingulate cortex; depressive symptoms; disability; early onset; effective therapy; executive function; functional decline; inclusion criteria; information processing; lamotrigine; meetings; mitochondrial dysfunction; mortality; neuropsychological; older patient; open label; processing speed; programs; response; responsible research conduct; treatment response; young adult

DESCRIPTION (provided by applicant): Dr. Forester aims to become an independent investigator in the field of geriatric bipolar disorder using magnetic resonance spectroscopy (MRS) to study biochemical markers of treatment response. Long-term career goals include collaboration with other centers employing MR imaging (MRI) technologies to study geriatric bipolar disorder with a focus on developing safe and effective therapeutic interventions. Dr. Forester will be mentored at McLean Hospital by Dr. Bruce Cohen, past President of McLean Hospital and current Director of the Frazier Institute, an interdisciplinary consortium studying bipolar disorder using clinical pharmacology, MRS, functional MR and laboratory techniques, and co-mentored by Dr. Perry Renshaw, of the McLean Hospital Brain Imaging Center. Dr. Forester will enhance his clinical skills with formal training in MRI techniques and applications, biostatistics and the responsible conduct of research. The proposed research plan will employ MRS to study measures of brain energy metabolism in 35 older adults with bipolar depression and 25 healthy age-matched controls. Subjects meeting inclusion criteria will be clinically characterized at baseline with a structured psychiatric interview and neuropsychological testing and will undergo proton (1H) MRS study at 4 Tesla. Subjects with bipolar depression will then receive open label treatment with lamotrigine as monotherapy or adjunctive therapy for eight weeks. At the end of 8 weeks, both groups will undergo a second 1H MRS scan at 4 Tesla. Group differences in the brain energy metabolites, glutamate, glutamine, N-acetyl aspartate and lactate, among control subjects and subjects with bipolar disorder will be analyzed at baseline and after treatment.

描述（由申请人提供）：Forester博士的目的是使用磁共振光谱（MRS）研究老年躁郁症领域的独立研究者，以研究治疗反应的生化标志物。长期职业目标包括与其他采用MR成像（MRI）技术研究老年躁郁症的中心合作，重点是开发安全有效的治疗干预措施。 Forester博士将在麦克莱恩医院（McLean Hospital）由McLean Hospital的前任主席，现任Frazier Institute的主任Bruce Cohen博士进行指导，Frazier Institute是一个跨学科的财团，使用临床药理学，MRS，功能性MR和实验室技术研究双极疾病，并由McLean Hospital Hospital Hospital Brine Image Center进行了Perry Renshaw博士。 Forester博士将通过MRI技术和应用，生物统计学和负责任的研究进行正式培训来提高他的临床技能。拟议的研究计划将利用MRS研究35名患有躁郁症抑郁症和25个健康年龄匹配的对照的老年人的脑能量代谢的措施。符合纳入标准的受试者将在基线上通过结构化的精神访谈和神经心理学测试在临床上进行临床表征，并将在4 Tesla进行质子（1H）MRS研究。然后，患有躁郁症抑郁症的受试者将接受八个星期的单一疗法或辅助治疗的开放式标签治疗。在8周结束时，两组将在4特斯拉进行第二次1小时扫描MRS扫描。在基线和治疗后，将分析脑能量代谢产物，谷氨酸，谷氨酰胺，谷氨酸天冬氨酸和乳酸的群体差异，对照组和患有双相情感障碍的受试者的群体差异。

项目成果

Clinical Characteristics of Patients with Late Life Bipolar Disorder in the Community: Data from the NNDC Registry.

社区晚年双相情感障碍患者的临床特征：来自 NNDC 登记处的数据。

• DOI: 10.1016/j.jagp.2015.01.001
• 发表时间: 2015
• 期刊: The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
• 作者: Forester,BrentP;Ajilore,Olu;Spino,Cathie;Lehmann,SusanW
• 通讯作者: Lehmann,SusanW

Antidepressant effects of open label treatment with coenzyme Q10 in geriatric bipolar depression.

• DOI: 10.1097/jcp.0000000000000326
• 发表时间: 2015-06
• 期刊: Journal of clinical psychopharmacology
• 影响因子: 2.9
• 作者: Forester BP;Harper DG;Georgakas J;Ravichandran C;Madurai N;Cohen BM
• 通讯作者: Cohen BM

Spiritual struggle and affective symptoms among geriatric mood disordered patients.

• DOI: 10.1002/gps.4052
• 发表时间: 2014-06
• 期刊: INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
• 影响因子: 4
• 作者: Rosmarin, David H.;Malloy, Mary C.;Forester, Brent P.
• 通讯作者: Forester, Brent P.

Interest in spiritually integrated psychotherapy among acute psychiatric patients.

对急性精神病患者的精神整合心理治疗感兴趣。

• DOI: 10.1037/ccp0000046
• 发表时间: 2015
• 期刊: Journal of consulting and clinical psychology
• 影响因子: 5.9
• 作者: Rosmarin,DavidH;Forester,BrentP;Shassian,DanielM;Webb,ChristianA;Björgvinsson,Thröstur
• 通讯作者: Björgvinsson,Thröstur

Lamotrigine Therapy and Biomarkers of Cerebral Energy Metabolism in Older Age Bipolar Depression.

拉莫三嗪治疗和老年双相抑郁症脑能量代谢的生物标志物。

• DOI: 10.1016/j.jagp.2019.02.017
• 发表时间: 2019
• 期刊: The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
• 作者: Mellen,EmilyJ;Harper,DavidG;Ravichandran,Caitlin;Jensen,Eric;Silveri,Marisa;Forester,BrentP
• 通讯作者: Forester,BrentP