Assessing HIV-associated Neurocognitive Impairment in Spanish Speakers

评估西班牙语使用者中与艾滋病毒相关的神经认知障碍

• 批准号: 8452176
• 负责人: ENRIQUE LOPEZ
• 金额: $ 17.71万
• 依托单位: CEDARS-SINAI MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8452176
• 关键词: AIDS Dementia Complex; AIDS neuropathy; Address; Adult; Area; Award; Behavioral; Boston; Clinical; Clinical Research; Cognitive; Collaborations; Consensus; Data; Development Plans; Diagnosis; Disease; Doctor of Medicine; Doctor of Philosophy; Educational Curriculum; Epidemic; Evaluation; Face; Familiarity; Goals; Grant; HIV; HIV Infections; HIV-1; Head; Hispanics; Human immunodeficiency virus test; Impairment; Individual; International; Language; Los Angeles; Measures; Medical center; Mentors; Mentorship; Minority; Modeling; Modification; Names; National Institute of Mental Health; Neurocognition; Neurocognitive; Neuropsychology; Neurorehabilitation; Neurosciences; Participant; Persons; Population; Psychiatry; Psychology; Receiver Operating Characteristics; Research; Sampling; Science; Senior Scientist; Sensitivity and Specificity; Services; Staging; Structure; Techniques; Testing; Training; Training Programs; Translations; United States National Institutes of Health; Validation; Vocabulary; biobehavior; bropirimine; career; career development; design; experience; instrument; interest; medical schools; medication compliance; meetings; mental state; multidisciplinary; neuropsychiatry; neuropsychological; patient oriented research; prevent; professor; psychosocial; screening; therapy development; tool; transmission process; treatment program

DESCRIPTION (provided by applicant): Dr. Enrique Lopez is an Assistant Professor, and the Head of the Psychology Section in the Department of Psychiatry and Behavioral Neurosciences at Cedars-Sinai Medical Center (CSMC) and an Assistant Clinical Professor in the Department of Psychiatry and Biobehavioral Sciences at the David Geffen School of Medicine at UCLA. Dr. Lopez's long-term goal is to develop an independent career in clinical research in the area of HIV-associated neurocognitive disorders. Dr. Lopez has had a long-term interest in creating better neurocognitive assessment tools and neurorehabilitation treatment programs for Spanish speaking individuals, specifically those diagnosed with HIV-associated neurocognitive disorders (HAND). Under the mentorship of Robert M. Cohen, Ph.D., M.D., Karl Goodkin, M.D., Ph.D., Charles H. Hinkin, Ph.D., ABPP-CN, and David J. Martin, Ph.D., Dr. Lopez will investigate HAND in Spanish-speaking individuals while obtaining a personalized training program by senior scientists in the area of neuroAIDS from CSMC, UCLA, and Harbor-UCLA Medical Center. The proposed career development plan provides an intense, closely mentored, patient-oriented research experience in association with a comprehensively structured didactic clinical research curriculum. The first objective of the study is to validate the Los Angeles version of the HUMANS battery for Hispanics infected by HIV. The original HUMANS battery has been developed by Dr. Karl Goodkin as part of an NIH grant he received. The newly revised battery will be administered in a sample of 30 HIV-seronegative adults to obtain preliminary data with this specific Spanish-speaking population as well as to 100 HIV-seropositive persons (20 participants will be re-administered the NP battery in order to obtain re-test reliability data). After establishment of a valid measure to assess for HAND among Spanish-speakers in the Los Angeles area, the study will investigate if Spanish language cognitive screening tools can detect HAND as well as a comprehensive neuropsychological evaluation. Rapid screening cognitive tests for HAND are of great need in this population because of their utility in clinical settings. Additionally, the relationship between medication adherence and neurocognition among this Spanish-speaking population will be evaluated. Little information is known about medication adherence and neurocognitive disorders among this Spanish-speaking population infected with HIV. Ultimately, this study will provide Dr. Lopez with reliable and valid HIV-1-associated neurocognitive impairment data among the unique Los Angeles disenfranchised group to develop a research clinical derived multidisciplinary treatment program for medication adherence in Spanish-speakers suffering from HAND in order to submit an R21 grant. This specialized training will further his collaborations among other senior scientists in the area of neuroAIDS for Dr. Lopez to conduct independent research among minority individuals who are impacted with HIV.

描述（由申请人提供）：Enrique Lopez 博士是 Cedars-Sinai 医疗中心 (CSMC) 精神病学和行为神经科学系助理教授、心理学科主任以及精神病学系助理临床教授加州大学洛杉矶分校大卫格芬医学院的生物行为科学和生物行为科学。洛佩兹博士的长期目标是在艾滋病毒相关神经认知障碍领域的临床研究中发展独立的职业生涯。洛佩兹博士长期以来一直致力于为讲西班牙语的人，特别是那些被诊断患有艾滋病毒相关神经认知障碍 (HAND) 的人创建更好的神经认知评估工具和神经康复治疗计划。在 Robert M. Cohen 博士、医学博士、Karl Goodkin 医学博士、博士、Charles H. Hinkin 博士、ABPP-CN 和 David J. Martin 博士的指导下。洛佩兹博士将在西班牙语人群中研究 HAND，同时获得来自 CSMC、加州大学洛杉矶分校和 Harbour-UCLA 医疗中心神经艾滋病领域资深科学家的个性化培训计划。拟议的职业发展计划提供了密集的、密切指导的、以患者为导向的研究经验，并结合了全面结构化的教学临床研究课程。该研究的第一个目标是验证洛杉矶版本的 HUMANS 电池适用于感染艾滋病毒的西班牙裔人。最初的 HUMANS 电池是由 Karl Goodkin 博士开发的，作为他获得的 NIH 资助的一部分。新修订的电池组将在 30 名 HIV 血清阴性成年人样本中进行，以获得该特定西班牙语人群以及 100 名 HIV 血清阳性者的初步数据（20 名参与者将重新接受 NP 电池组测试，以便获得重新测试的可靠性数据）。在建立有效的措施来评估洛杉矶地区西班牙语使用者的 HAND 后，该研究将调查西班牙语认知筛查工具是否可以检测 HAND 以及全面的神经心理学评估。由于 HAND 快速筛查认知测试在临床环境中的实用性，该人群非常需要它们。此外，还将评估西班牙语人群的药物依从性和神经认知之间的关系。关于感染艾滋病毒的西班牙语人群的药物依从性和神经认知障碍的信息知之甚少。最终，这项研究将为 Lopez 博士提供洛杉矶独特的被剥夺权利群体中可靠且有效的 HIV-1 相关神经认知障碍数据，以开发一项研究临床衍生的多学科治疗计划，以帮助患有 HAND 的西班牙语使用者坚持药物治疗，以便提交 R21 补助金。这项专门培训将进一步促进洛佩兹博士与神经艾滋病领域其他资深科学家的合作，以便在感染艾滋病毒的少数群体中开展独立研究。

项目成果

Diagnostic utility of the HIV dementia scale and the international HIV dementia scale in screening for HIV-associated neurocognitive disorders among Spanish-speaking adults.

HIV 痴呆量表和国际 HIV 痴呆量表在西班牙语成人中筛查 HIV 相关神经认知障碍的诊断效用。

• DOI: 10.1080/23279095.2016.1214835
• 发表时间: 2017
• 期刊: Applied neuropsychology. Adult
• 作者: López,Enrique;Steiner,AlexanderJ;Smith,Kimberly;Thaler,NicholasS;Hardy,DavidJ;Levine,AndrewJ;Al-Kharafi,HussahT;Yamakawa,Cristina;Goodkin,Karl
• 通讯作者: Goodkin,Karl