Assessing HIV-associated Neurocognitive Impairment in Spanish Speakers

评估西班牙语使用者中与艾滋病毒相关的神经认知障碍

• 批准号: 8140774
• 负责人: ENRIQUE LOPEZ
• 金额: $ 17.47万
• 依托单位: CEDARS-SINAI MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8140774
• 关键词: AIDS Dementia Complex; AIDS neuropathy; Address; Adult; Area; Award; Behavioral; Boston; Clinical; Clinical Research; Cognitive; Collaborations; Consensus; Data; Development Plans; Diagnosis; Disease; Doctor of Medicine; Doctor of Philosophy; Educational Curriculum; Epidemic; Evaluation; Face; Familiarity; Goals; Grant; HIV; HIV Infections; HIV-1; Head; Hispanics; Human immunodeficiency virus test; Impairment; Individual; International; Language; Los Angeles; Measures; Medical center; Mentors; Mentorship; Minority; Modeling; Modification; Names; National Institute of Mental Health; Neurocognition; Neurocognitive; Neuropsychology; Neurorehabilitation; Neurosciences; Participant; Persons; Population; Psychiatry; Psychology; Receiver Operating Characteristics; Research; Sampling; Science; Screening procedure; Senior Scientist; Sensitivity and Specificity; Services; Staging; Structure; Techniques; Testing; Training; Training Programs; Translations; United States National Institutes of Health; Validation; Vocabulary; biobehavior; bropirimine; career; career development; design; experience; instrument; interest; medical schools; medication compliance; meetings; mental state; multidisciplinary; neuropsychiatry; neuropsychological; patient oriented research; prevent; professor; psychosocial; therapy development; tool; transmission process; treatment program

DESCRIPTION (provided by applicant): Dr. Enrique Lopez is an Assistant Professor, and the Head of the Psychology Section in the Department of Psychiatry and Behavioral Neurosciences at Cedars-Sinai Medical Center (CSMC) and an Assistant Clinical Professor in the Department of Psychiatry and Biobehavioral Sciences at the David Geffen School of Medicine at UCLA. Dr. Lopez's long-term goal is to develop an independent career in clinical research in the area of HIV-associated neurocognitive disorders. Dr. Lopez has had a long-term interest in creating better neurocognitive assessment tools and neurorehabilitation treatment programs for Spanish speaking individuals, specifically those diagnosed with HIV-associated neurocognitive disorders (HAND). Under the mentorship of Robert M. Cohen, Ph.D., M.D., Karl Goodkin, M.D., Ph.D., Charles H. Hinkin, Ph.D., ABPP-CN, and David J. Martin, Ph.D., Dr. Lopez will investigate HAND in Spanish-speaking individuals while obtaining a personalized training program by senior scientists in the area of neuroAIDS from CSMC, UCLA, and Harbor-UCLA Medical Center. The proposed career development plan provides an intense, closely mentored, patient-oriented research experience in association with a comprehensively structured didactic clinical research curriculum. The first objective of the study is to validate the Los Angeles version of the HUMANS battery for Hispanics infected by HIV. The original HUMANS battery has been developed by Dr. Karl Goodkin as part of an NIH grant he received. The newly revised battery will be administered in a sample of 30 HIV-seronegative adults to obtain preliminary data with this specific Spanish-speaking population as well as to 100 HIV-seropositive persons (20 participants will be re-administered the NP battery in order to obtain re-test reliability data). After establishment of a valid measure to assess for HAND among Spanish-speakers in the Los Angeles area, the study will investigate if Spanish language cognitive screening tools can detect HAND as well as a comprehensive neuropsychological evaluation. Rapid screening cognitive tests for HAND are of great need in this population because of their utility in clinical settings. Additionally, the relationship between medication adherence and neurocognition among this Spanish-speaking population will be evaluated. Little information is known about medication adherence and neurocognitive disorders among this Spanish-speaking population infected with HIV. Ultimately, this study will provide Dr. Lopez with reliable and valid HIV-1-associated neurocognitive impairment data among the unique Los Angeles disenfranchised group to develop a research clinical derived multidisciplinary treatment program for medication adherence in Spanish-speakers suffering from HAND in order to submit an R21 grant. This specialized training will further his collaborations among other senior scientists in the area of neuroAIDS for Dr. Lopez to conduct independent research among minority individuals who are impacted with HIV. PUBLIC HEALTH RELEVANCE: Primary Spanish speakers with HIV infection today are frequently assessed for neurocognitive and other neuropsychiatric disorders using instruments administered in English due to convenience. However, this may generate invalid results, over-estimating the rate of neurocognitive disorders due to less English familiarity. This study will address the need to modify and further evaluate the HUMANS battery, a translation of a battery derived from the NIMH Consensus Battery for neurocognitive evaluation of HIV infected persons into Spanish for its use in the greater Los Angeles area, meeting the outstanding clinical need.

描述（由申请人提供）：恩里克·洛佩兹（Enrique Lopez）博士是助理教授，也是精神病学和行为神经科学系的负责人，锡达尔 - 西奈医学中心（CSMC）（CSMC）和精神病学和生物行为科学系的助理临床教授，乌克拉（David Geffen）在乌克拉（Ucla）的大卫·盖芬（David Geffen）学校。洛佩兹博士的长期目标是在与HIV相关的神经认知障碍领域发展独立的临床研究职业。洛佩兹（Lopez）博士对为西班牙语的人，特别是那些患有HIV相关神经认知疾病的人（手）（手）创建更好的神经认知评估工具和神经居住治疗计划有长期兴趣。在罗伯特·M·科恩（Robert M. Cohen）博士学位的指导下 中心。拟议的职业发展计划提供了一项激烈，受到指导，以患者为导向的研究经验，并与一项结构化的教学临床研究课程相关联。该研究的第一个目的是验证洛杉矶版本的人类电池，以感染艾滋病毒的西班牙裔。原始的人类电池是由Karl Goodkin博士开发的，作为他收到的NIH赠款的一部分。新修订的电池将在30个HIV副成年人的样本中进行管理，以获取具有该特定西班牙语的人群以及100名HIV呼吸阳性人士的初步数据（将重新管理NP电池的20名参与者，以获得重新测试可靠性数据）。在建立了一项有效的措施来评估洛杉矶地区西班牙扬声器之间的手之后，该研究将调查西班牙语认知筛查工具是否可以检测手以及全面的神经心理学评估。由于它们在临床环境中的实用性，因此在该人群中快速筛选手工认知测试非常需要。此外，将评估这种说西班牙语人群中药物依从性与神经认知之间的关系。关于用艾滋病毒感染的西班牙语人群中的药物依从性和神经认知障碍的信息知之甚少。最终，这项研究将为洛佩兹博士提供可靠且有效的HIV-1相关神经认知障碍数据，洛杉矶独特的剥夺了特权的群体，以制定一项研究临床衍生的多学科治疗计划，以依从性，以依从于言论的西班牙言论者，以便提交R21赠款。这项专业培训将进一步在神经助理领域的其他高级科学家中为洛佩兹博士的其他高级科学家进行，以对受艾滋病毒影响的少数族裔个人进行独立研究。 公共卫生相关性：当今患有艾滋病毒感染的主要西班牙语人士经常通过使用英语来评估神经认知和其他神经精神疾病的神经认知和其他神经精神疾病。但是，这可能会产生无效的结果，从而高估了由于英语熟悉程度较少而导致的神经认知障碍率。这项研究将满足修改和进一步评估人类电池的需求，这是对NIMH共识电池的电池翻译，用于将艾滋病毒感染者在西班牙语中进行神经认知评估，以在大洛杉矶地区使用，以满足出色的临床需求。