Research and Mentoring on Integrating Psychiatric Genetics and Neuroscience

整合精神遗传学和神经科学的研究和指导

基本信息

批准号：
8467053
负责人：
JORDAN W SMOLLER
金额：
$ 18.59万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-05-07 至 2017-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8467053
关键词：
Address Adolescent Age American Anxiety Anxiety Disorders Architecture Area Attention deficit hyperactivity disorder Autistic Disorder Award Base of the Brain Behavior Behavioral Behavioral Genetics Biology Bipolar Disorder Brain Brain imaging Clinical Clinical Research Cognition Collection Communities DNA Data Data Aggregation Data Analyses Data Set Development Development Plans Diagnostic Disease Environment Epidemiologic Studies European Faculty Fruit Functional Magnetic Resonance Imaging Funding Generations Genetic Genetic Research Genetic Variation Genomic Library Genomics Genotype Goals Grant Hereditary Disease Image Individual Infant Interdisciplinary Study International Investigation Jordan Laboratories Leadership Longitudinal Studies Machine Learning Major Depressive Disorder Maps Measures Mental Depression Mental Health Mental disorders Mentors Mentorship Methods Midcareer Investigator Award in Patient-Oriented Research National Institute of Mental Health Neurosciences Pathology Personality Phenotype Predisposition Principal Investigator Psychotic Disorders Public Health Quality Control Research Research Personnel Research Project Grants Research Training Resources Role Sampling Schizophrenia Scientist Services Strategic Planning Structure Suicide Technology Temperament Time Training Transcend Translational Research Variant Work base career career development cohort design disorder risk experience functional disability gene discovery genetic analysis genetic variant genome wide association study genome-wide innovation medical schools neuroimaging neuropsychiatry patient oriented patient oriented research programs psychogenetics relating to nervous system research and development resilience risk variant trait

项目摘要

DESCRIPTION (provided by applicant): This Mid-Career Investigator Award in Patient-Oriented Research will permit the Principal Investigator to expand his mentorship, career development, and research on the integration of patient-oriented psychiatric genetics and neuroscience. The Principal Investigator is an established clinician-scientist in psychiatric genetics and clinical research. This application includes three components: 1) a mentoring plan designed to enhance the Principal Investigator's ability to mentor young investigators in psychiatric genetics and neuroscience; 2) a career development plan designed to expand the Principal Investigator's expertise in the integration of genetics and neuroimaging; and 3) a research plan that leverages the Principal Investigator's existing investigations on the genetic, behavioral and neural basis of psychiatric disorders and their relationship to normal variation in brain structure and function. The Principal Investigator has a substantial track record of mentoring and cultivating trainees and junior faculty in the area of genetic, clinical and epidemiologic research. This award would provide protected time for the Principal Investigator to expand and enhance these efforts. The mentoring plan capitalizes on his current mentoring activities and numerous collaborative research projects to develop a career development path for a new generation of investigators capable of integrating cutting-edge methods at the interface of patient-oriented genetics and neuroscience. Mentees will gain hands-on experience in patient-oriented research and will develop their own independent research directions. The clinical and translational research resources at MGH and the broader Harvard Medical School community will provide a rich training environment for mentees. The new research component of the application will include genomewide analyses of brain phenotypes to examine the genetic and neural architecture of anxiety disorders. This application was designed to address objectives identified by NIMH's Strategic Plan to fuel research on the causes of mental disorders and the National Advisory Mental Health Council Workgroup on Research Training to expand mentoring of young investigators capable of conducting the interdisciplinary research needed to achieve those objectives.

描述（由申请人提供）：这项以患者为导向的研究中的职业生涯中期研究员奖将允许首席研究员扩大他的指导、职业发展以及以患者为导向的精神遗传学和神经科学整合的研究。首席研究员是一位在精神病遗传学和临床研究领域颇有建树的临床医生科学家。该申请包括三个组成部分：1）指导计划，旨在提高首席研究员指导精神遗传学和神经科学领域年轻研究者的能力； 2) 旨在扩展首席研究员在遗传学和神经影像学整合方面的专业知识的职业发展计划； 3) 一项研究计划，该计划利用了首席研究员对精神疾病的遗传、行为和神经基础及其与大脑结构和功能正常变异的关系的现有研究。首席研究员在指导和培养遗传、临床和流行病学研究领域的实习生和初级教师方面拥有丰富的记录。该奖项将为首席研究员提供受保护的时间来扩大和加强这些努力。该指导计划利用他目前的指导活动和众多合作研究项目，为能够在以患者为导向的遗传学和神经科学领域整合尖端方法的新一代研究人员制定职业发展道路。学员将获得以患者为导向的研究的实践经验，并将发展自己的独立研究方向。 MGH 和更广泛的哈佛医学院社区的临床和转化研究资源将为学员提供丰富的培训环境。该应用程序的新研究部分将包括对大脑表型进行全基因组分析，以检查焦虑症的遗传和神经结构。该应用程序旨在实现 NIMH 战略计划确定的目标，以推动对精神障碍原因的研究，以及国家咨询心理健康委员会研究培训工作组确定的目标，以扩大对能够进行实现这些目标所需的跨学科研究的年轻研究人员的指导。