Real time fMRI feedback and auditory processing in schizophrenia
精神分裂症的实时功能磁共振成像反馈和听觉处理
基本信息
- 批准号:8509122
- 负责人:
- 金额:$ 18.21万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-06-10 至 2015-04-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (provided by applicant): Auditory verbal hallucinations (AH) have long been a hallmark of schizophrenia (SZ) symptomatology and one of its major diagnostic features (Andreasen and Flaum, 1991; DSM-IV). It has been demonstrated that the brain regions implicated in AH are involved in different aspects of language processing. This brain network includes the temporal cortex and especially the superior temporal gyrus (STG), anterior cingulate (ACC), inferior frontal gyrus (IFG), and temporo-parietal junction (TPJ). Until recently,
AH were primarily controlled with antipsychotic medication which was often ineffective. In this application, we propose to use a cutting-edge biofeedback method of real-time functional imaging neuro-feedback (rt-fMRI) to reduce the frequency of AH and to better understand brain processes involved in AH. We adopt the Hugdahl 2009 model of AH according to which AH result from abnormalities in self-monitoring of speech, in selective attention and in auditory perceptual processes. We focus on the role of auditory cortex, specifically the STG, as a target area of neuro-feedback training for the treatment of AH in SZ. Based on existing literature, we posit that that improved function in the STG will normalize the entire network involved in the experience of AH. We predict that the activation in the STG (and regions forming AH network: IFG, ACC, and TPJ) will increase as a result of receiving feedback from that region which will lead to a better performance on the task of recognizing self/other voice as measured by fMRI activation levels pre-and post-rt-fMRI training and by reduction in positive symptoms and especially AH. The rt-fMRI neuro-feedback relies on recent advances in computer technology that allows subjects to see the level of activation in the selected brain region and to regulate ths activation following the training provided. Subjects are taught to up-regulate or down-regulate fMRI signal within a specific brain region selected based on the activation task. Importantly, reported activation changes are possible only if the subject receives a feedback from his/her target area and not when she/he receives it from a different subject or a different area than the target one (sham). It has been recently demonstrated that this approach may be helpful in many clinical conditions, among them schizophrenia (Haller 2010; Sitaran 2011;Linden 2012;Veit 2009; Hartwell 2012; Li 2012, Ruiz 2011). In this study we propose to study 30 chronic SZ patients and 30 normal control (NC) individuals (half of them will receive real and half will receive a sham fMRI feedback). We will use both fMRI (including two measures of connectivity) and clinical measures of the effectiveness of the rt-fMRI feedback. Based on the existing literature and our preliminary data, we predict that we will successfully improve auditory processing within the STG and within the targeted network and that it will lead to improvement in the clinical symptoms and especially in the frequency of AH.
描述(由申请人提供):听觉言语幻觉(AH)长期以来一直是精神分裂症(SZ)症状学的标志及其主要诊断特征之一(Andreasen和Flaum,1991; DSM-IV)。已经证明,与AH有关的大脑区域与语言处理的不同方面有关。该大脑网络包括颞皮层,尤其是上颞回(STG),前扣带回(ACC),下额回(IFG)和颞顶连接(TPJ)。直到最近,
AH主要用抗精神病药物控制,通常无效。在此应用中,我们建议使用实时功能成像神经反馈(RT-FMRI)的最先进的生物反馈方法来降低AH的频率并更好地了解AH涉及的大脑过程。我们采用了Hugdahl 2009 AH模型,根据该模型,AH是由于语音自我监测,选择性关注和听觉感知过程的异常而产生的。我们专注于听觉皮层,特别是STG的作用,是在SZ中治疗AH的神经反馈培训的目标领域。根据现有文献,我们认为,改善STG功能的功能将使与AH体验有关的整个网络正常化。我们预测,由于接收来自该地区的反馈,STG的激活(以及形成AH网络:IFG,ACC和TPJ)将增加,这将导致在识别fMRI激活水平衡量的自我/其他声音的任务上,通过RT-FMRI训练和RT-RT-FMRI训练和降低阳性症状降低阳性症状,尤其是AH。 RT-FMRI神经反馈依赖于计算机技术的最新进展,该技术使受试者能够看到所选大脑区域的激活水平并在提供的训练后调节THS激活。根据激活任务,教导受试者在特定的大脑区域内上调或下调fMRI信号。重要的是,只有当受试者从其目标区域收到反馈时,而不是当她/他从其他受试者或与目标一个区域不同的区域(假)接收到它时,才有可能发生的激活变化。最近已经证明,这种方法在许多临床状况中可能有帮助,其中包括精神分裂症(Haller 2010; Sitaran 2011; Linden 2012; Veit 2009; Hartwell 2009; Hartwell 2012; Li 2012,Ruiz 2011)。在这项研究中,我们建议研究30名慢性SZ患者和30名正常对照(NC)个体(其中一半将获得真实的frim,一半将获得fMRI的反馈)。我们将同时使用fMRI(包括两种连通性的度量)和RT-FMRI反馈有效性的临床度量。根据现有文献和我们的初步数据,我们预测我们将成功改善STG内部和目标网络内的听觉处理,并将导致临床症状,尤其是AH的频率改善。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

暂无数据
数据更新时间:2024-06-01
MARGARET A NIZNIKI...的其他基金
Real-time fMRI Neurofeedback as a Tool to Mitigate Auditory Hallucinations in Patients with Schizophrenia
实时功能磁共振成像神经反馈作为减轻精神分裂症患者幻听的工具
- 批准号:1061547810615478
- 财政年份:2022
- 资助金额:$ 18.21万$ 18.21万
- 项目类别:
Real-time fMRI Neurofeedback as a Tool to Mitigate Auditory Hallucinations in Patients with Schizophrenia
实时功能磁共振成像神经反馈作为减轻精神分裂症患者幻听的工具
- 批准号:1001970010019700
- 财政年份:2018
- 资助金额:$ 18.21万$ 18.21万
- 项目类别:
Real-time fMRI Neurofeedback as a Tool to Mitigate Auditory Hallucinations in Patients with Schizophrenia
实时功能磁共振成像神经反馈作为减轻精神分裂症患者幻听的工具
- 批准号:1070469010704690
- 财政年份:2018
- 资助金额:$ 18.21万$ 18.21万
- 项目类别:
Real time fMRI feedback and auditory processing in schizophrenia
精神分裂症的实时功能磁共振成像反馈和听觉处理
- 批准号:86769408676940
- 财政年份:2013
- 资助金额:$ 18.21万$ 18.21万
- 项目类别:
Neurophysiological and MRI Studies of Schizophrenia
精神分裂症的神经生理学和 MRI 研究
- 批准号:93372449337244
- 财政年份:2009
- 资助金额:$ 18.21万$ 18.21万
- 项目类别:
Semantic knowledge and its underlying structures in schizophrenia-an fMRI study
精神分裂症的语义知识及其底层结构——一项功能磁共振成像研究
- 批准号:72517707251770
- 财政年份:2007
- 资助金额:$ 18.21万$ 18.21万
- 项目类别:
Language Systems in Schizophrenia: Behavioral & ERP Data
精神分裂症的语言系统:行为
- 批准号:68916836891683
- 财政年份:2002
- 资助金额:$ 18.21万$ 18.21万
- 项目类别:
Language Systems in Schizophrenia: Behavioral & ERP Data
精神分裂症的语言系统:行为
- 批准号:70754407075440
- 财政年份:2002
- 资助金额:$ 18.21万$ 18.21万
- 项目类别:
Language Systems in Schizophrenia: Behavioral & ERP Data
精神分裂症的语言系统:行为
- 批准号:67425366742536
- 财政年份:2002
- 资助金额:$ 18.21万$ 18.21万
- 项目类别:
Language Systems in Schizophrenia: Behavioral & ERP Data
精神分裂症的语言系统:行为
- 批准号:64719426471942
- 财政年份:2002
- 资助金额:$ 18.21万$ 18.21万
- 项目类别:
相似国自然基金
肝胆肿瘤治疗性溶瘤腺病毒疫苗的研制及其临床前应用性探索
- 批准号:82303776
- 批准年份:2023
- 资助金额:30 万元
- 项目类别:青年科学基金项目
莫氏细胞早期异常活化介导的前下托-齿状回环路构建在癫痫发生中的作用研究
- 批准号:82371458
- 批准年份:2023
- 资助金额:49 万元
- 项目类别:面上项目
基于MST4-YAP-MYC信号通路的慢痞消调控氧化磷酸化水平治疗胃癌前病变的机制研究
- 批准号:82374292
- 批准年份:2023
- 资助金额:49 万元
- 项目类别:面上项目
CXCL12趋化CXCR4+/α-SMA+成骨前体细胞促进黄韧带骨化的机制研究
- 批准号:82302745
- 批准年份:2023
- 资助金额:30 万元
- 项目类别:青年科学基金项目
紫外光解中间体激活荧光构建亚硝胺及其前体物的新方法和机理研究
- 批准号:82373631
- 批准年份:2023
- 资助金额:49 万元
- 项目类别:面上项目
相似海外基金
Functional MRI in Schizophrenia
精神分裂症的功能性 MRI
- 批准号:1068120210681202
- 财政年份:2022
- 资助金额:$ 18.21万$ 18.21万
- 项目类别:
Functional MRI in Schizophrenia
功能性 MRI 在精神分裂症中的应用
- 批准号:1037321210373212
- 财政年份:2022
- 资助金额:$ 18.21万$ 18.21万
- 项目类别:
Toward a Computationally-Informed, Personalized Treatment for Hallucinations
迈向基于计算的个性化幻觉治疗
- 批准号:1015932910159329
- 财政年份:2020
- 资助金额:$ 18.21万$ 18.21万
- 项目类别:
Real time fMRI feedback and auditory processing in schizophrenia
精神分裂症的实时功能磁共振成像反馈和听觉处理
- 批准号:86769408676940
- 财政年份:2013
- 资助金额:$ 18.21万$ 18.21万
- 项目类别:
The Pathophysiology and Treatment Of Children With Severe Mood Dysregulation
儿童严重情绪失调的病理生理学和治疗
- 批准号:83421298342129
- 财政年份:
- 资助金额:$ 18.21万$ 18.21万
- 项目类别: