Functional MRI in Schizophrenia

功能性 MRI 在精神分裂症中的应用

• 批准号: 10373212
• 负责人: Weiying Dai
• 金额: $ 27.32万
• 依托单位: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10373212
• 关键词: 3-Dimensional; Acute; Adopted; Anterior; Antipsychotic Agents; Area; Biological Markers; Bipolar Disorder; Brain; Brain region; Caffeine; Cerebrovascular Circulation; Clinical; Detection; Diagnosis; Disease; Dropout; Foundations; Frequencies; Functional Magnetic Resonance Imaging; Functional disorder; Hippocampus (Brain); Image; Imaging Techniques; Label; Literature; Magnetic Resonance Imaging; Maps; Measures; Methodology; Methods; Modeling; Morphologic artifacts; Motion; Multicenter Studies; Patients; Pharmaceutical Preparations; Physiological; Prediction of Response to Therapy; Predisposition; Reporting; Reproducibility; Resolution; Rest; Role; Sample Size; Schizophrenia; Series; Signal Transduction; Symptoms; Techniques; Testing; Time; Validation; Variant; arterial spin labeling; base; blood oxygen level dependent; cingulate cortex; cohort; improved; neuroimaging; neuropathology; novel; novel imaging technique; potential biomarker; recruit; temporal measurement

Project Summary/Abstract The hippocampus (HPC) is one area of the brain that is broadly implicated in the pathophysiology of schizophrenia (SZ). Functional connectivity models of SZ suggest that disturbances also exist in the functional connections between the HPC and multiple other brain regions and networks. Aberrant HPC resting-state functional connectivity (rsFC) has been reported with multiple brain regions and networks, but has not yet been consistent across the literature. Such inconsistency is mainly caused by the inherent limitation of the BOLD- based rsFC techniques in large susceptibility regions like HPC. Due to this limitation, HPC (as well as other susceptible regions) is often essentially excluded from contributing to whole-brain rsFC analyses. The inconsistency of findings for abnormal HPC rsFC not only severely hampers our understanding of the role of HPC in SZ neuropathology, but also markedly constrains the generalization of findings from various preliminary studies with small sample sizes, and may ultimately stunt the validation of potential biomarkers for SZ diagnosis and treatment. In this proof-of-concept study, we propose a single-shot single-label background-suppressed dynamic arterial spin labeling (sbDASL) technique to study rsFC with the HPC, both for the importance of elucidating its role in the pathophysiology of SZ, but also because it provides an ideal case to validate this novel imaging technique more broadly to examine FC with other areas and for whole brain analyses. The proposed sbDASL technique overcomes several current limitations of existing techniques in the study of rsFC in SZ. Most importantly, sbDASL improves the spatial and temporal resolution of existing DASL-based approaches for robust assessment of HPC rsFC. In the proposal, we will seek to develop the sbDASL technique and demonstrate its superiority in detecting HPC rsFC anterior cingulate cortex (ACC) and posterior cingulate cortex (PCC) in healthy subjects, and its improved reproducibility at baseline and sensitivity to acute caffeine challenge, compared to the BOLD technique. We will compare the effect sizes of the HPC rsFC with ACC and PCC in antipsychotic-free patients with SZ, relative to matched healthy controls, using sbDASL and BOLD. We will further explore the capability of sbDASL, compared to BOLD, in differentiating between SZ patients and healthy controls using rsFC measures across multiple brain networks.

项目概要/摘要 海马体 (HPC) 是大脑的一个区域，广泛涉及以下疾病的病理生理学： 精神分裂症（SZ）。 SZ 的功能连接模型表明，功能连接中也存在干扰。 HPC 与多个其他大脑区域和网络之间的连接。 HPC 静息态异常 据报道，功能连接（rsFC）与多个大脑区域和网络有关，但尚未得到证实 整个文献一致。这种不一致主要是由于BOLD-的固有限制造成的 基于 rsFC 技术的大型敏感区域（如 HPC）。由于此限制，HPC（以及其他 敏感区域）通常基本上被排除在全脑 RSFC 分析之外。这 异常 HPC rsFC 的结果不一致不仅严重妨碍了我们对异常 HPC rsFC 作用的理解 HPC 在 SZ 神经病理学中的应用，但也明显限制了各种初步研究结果的推广 样本量较小的研究，可能最终会阻碍 SZ 诊断潜在生物标志物的验证 和治疗。 在这项概念验证研究中，我们提出了一种单次单标签背景抑制动态动脉 自旋标记 (sbDASL) 技术与 HPC 一起研究 rsFC，这两者对于阐明其作用的重要性 SZ 的病理生理学，还因为它提供了验证这种新颖成像技术的理想案例 更广泛地检查 FC 与其他区域以及全脑分析。提出的 sbDASL 技术 克服了深圳 rsFC 研究中现有技术的一些局限性。最重要的是，sbDASL 提高现有基于 DASL 的方法的空间和时间分辨率，以实现 HPC 的稳健评估 rsFC。 在提案中，我们将寻求开发 sbDASL 技术并展示其在检测 HPC 方面的优越性 健康受试者的 rsFC 前扣带皮层 (ACC) 和后扣带皮层 (PCC) 及其改善情况 与 BOLD 技术相比，基线的重现性和对急性咖啡因挑战的敏感性。我们将 比较 HPC rsFC 与 ACC 和 PCC 在未使用抗精神病药物的 SZ 患者中的效应大小，相对于 使用 sbDASL 和 BOLD 匹配健康对照。我们将进一步探索 sbDASL 的能力，比较 BOLD，使用跨多个大脑的 rsFC 测量来区分 SZ 患者和健康对照 网络。