Emergence of Human Monkeypox in Central Africa

中部非洲出现人类猴痘

基本信息

批准号：
8259747
负责人：
Anne Walsh Rimoin
金额：
$ 12.18万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-05-15 至 2013-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8259747
关键词：
Affect Automobile Driving Behavior Behavioral Bioinformatics Biological Biological Assay Central Africa Climate Clinical Clinical Data Collection Comorbidity Congo Consumption Data Data Set Deterioration Development Diagnostic Disease Disease Outbreaks Environment Environmental Risk Factor Epidemiological Factors Epidemiology Equilibrium Evolution Exhibits Fostering Future Geographic Distribution Growth HIV Habitats Health Status Human Immunity Infection Integration Host Factors Intervention Lead Link Malnutrition Microbe Molecular Epidemiology Monkeypox Monkeypox virus National Institute of Allergy and Infectious Disease Natural History Parasites Pathogenesis Pathogenicity Play Population Poverty Prevalence Prevention Reporting Research Research Infrastructure Research Personnel Risk Risk Factors Role Scientist Smallpox Specimen Specimen Handling Sudan Therapeutic Intervention Time Training United States Vaccination Variant Viral Virulence Virus War anthropogenesis career development demographics design environmental change epidemiologic data forest genome sequencing interdisciplinary approach land use microbial migration pathogen predictive modeling programs remote sensing repository research and development statistics transmission process

项目摘要

Human monkeypox(MPX) is a smallpox-likedisease primarily reported in the rainforestsof CentralAfrica. Until recently, MPX was considered a rare zoonoticinfection in humans; howeverthe dramatic increase in ¿eports of human MPX over the last decade in the DemocraticRepublic of Congo(DRC) and recent outbreaks in the United States, Republic of Congo,and Sudan underscore the importance of understanding tie capacity and geographic rangefor disease emergence.To study the risk factors driving MPXgeographic distribution, prevalence, and risk of future emergence necessitates an interdisciplinary approach. The candidate proposes to undertake three primary career development activities: 1)training in remote sensing and spatial statistics; 2) training to understandthe fundamental aspects of specimen processing and analysis, including virus growth, PCR, sequencing of MPX virus specimens; and 3) training in advanced pidemiologic methodsto integrate ecologicand laboratorydata with epidemiologic and clinical data/These training objectives are linked to the following research objectives: 1) to determine if prevalence and geographic distribution of human MPX has increased over time; 2) to identify behavioral, demographic and environmental risk factors for human MPX infection; and 3) to understandthe role played by differential transmission and evolution of MPX.The researchcomponent will supplement and leverage a unique collection of biological specimens, existing research infrastructure in DRC, and access to remotely sensed data sets. The proposed research represents the first study in two decades to assessthe prevalence of MPX in an endemic region and to establish if the epidemiology of the virus has changed over time. Together, the career development and research activitiesproposedin this application will advance understanding of the variables that drive emergence of human MPX and support the development of the candidate as a productive independent investigator with the capacity to study fundamental ecologic, epidemiologic and biologic drivers of viral emergence.

人类Monkeypox（MPX）是Centralafrica的雨林中报道的天花 - 热蛋白酶。直到最近，MPX仍被认为是人类罕见的人畜共患感染。但是急剧增加 »刚果民主共和国（DRC）和最近的十年中人类MPX 美国，刚果共和国和苏丹的爆发强调了理解的重要性领带能力和地理范围对于疾病出现。未来出现的分配，普遍性和风险必要的跨学科方法。候选提议进行三个主要职业发展活动：1）遥感培训和空间统计； 2）培训以了解标本处理的基本方面和分析，包括病毒生长，PCR，MPX病毒标本的测序； 3）高级培训 PIDEMIologic Methodsto综合生态和实验室数据与流行病学和临床数据/ 培训目标与以下研究目标有关：1）确定是否患病率和是否随着时间的流逝，人类MPX的地理分布有所增加。 2）确定行为，人口统计和人类MPX感染的环境风险因素； 3）了解差异的作用 MPX的传播和演变。研究组合将补充和利用独特的收集生物标本，刚果民主共和国现有的研究基础设施以及远程感知的访问数据集。拟议的研究代表了评估MPX患病率的二十年中的第一项研究在一个流行地区，并确定病毒的流行病学是否随着时间的流逝而改变。在一起，职业发展和研究活动propospedin此应用将提高对推动人类MPX出现并支持候选人发展的变量生产性独立研究者，具有研究基本生态，流行病学和病毒出现的生物驱动因素。

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Cytokine modulation correlates with severity of monkeypox disease in humans.

DOI：
10.1016/j.jcv.2014.12.001
发表时间：
2015-02
期刊：
JOURNAL OF CLINICAL VIROLOGY
影响因子：
8.8
作者：
Johnston, Sara C.;Johnson, Joshua C.;Stonier, Spencer W.;Lin, Kenny L.;Kisalu, Neville K.;Hensley, Lisa E.;Rimoin, Anne W.
通讯作者：
Rimoin, Anne W.

Mapping a Filoviral Serologic Footprint in the Democratic Republic of the Congo: Who Goes There?

绘制刚果民主共和国的丝状病毒血清足迹：谁去了那里？

DOI：
10.1093/infdis/jix620
发表时间：
2018
期刊：
The Journal of infectious diseases
影响因子：
0
作者：
Crozier,Ian
通讯作者：
Crozier,Ian

Human T-cell lymphotropic virus type 1 transmission dynamics in rural villages in the Democratic Republic of the Congo with high nonhuman primate exposure.

DOI：
10.1371/journal.pntd.0008923
发表时间：
2021-01
期刊：
PLoS neglected tropical diseases
影响因子：
3.8
作者：
Halbrook M;Gadoth A;Shankar A;Zheng H;Campbell EM;Hoff NA;Muyembe JJ;Wemakoy EO;Rimoin AW;Switzer WM
通讯作者：
Switzer WM

Evolution of a Disease Surveillance System: An Increase in Reporting of Human Monkeypox Disease in the Democratic Republic of the Congo, 2001-2013.