Impacts of Urbanization on Vector Biology and Transmission of Dengue in China

中国城市化对媒介生物学和登革热传播的影响

• 批准号: 8289278
• 负责人: Xiaoguang Chen
• 金额: $ 10.29万
• 依托单位: SOUTHERN MEDICAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8289278
• 关键词: Acute; Adult; Aedes; Affect; Africa; Americas; Area; Asia; Biology; Blood Circulation; Breeding; China; Cities; Collection; Communicable Diseases; Competence; Country; Culicidae; Dengue; Dengue Hemorrhagic Fever; Dengue Virus; Development; Disease Outbreaks; Ecology; Economic Development; Environment; Epidemic; Epidemiology; Foundations; Frequencies; Genotype; Goals; Habitats; Larva; Life Tables; Methods; Molecular Epidemiology; Oceania; Pacific Ocean; Pattern; Phylogenetic Analysis; Population; Population Density; Prevention; Productivity; Province; Public Health; Publications; Reporting; Reproduction; Research; Risk; Role; Rural; Sampling; Serotyping; Southeastern Asia; Southern Africa; Testing; Travel; Urban Developments; Urbanization; Viral; Virus Diseases; World Health Organization; design; environmental change; field survey; programs; public health relevance; survivorship; transmission process; urban area; vector; vector transmission

DESCRIPTION (provided by applicant): Impacts of Urbanization on Vector Biology and Transmission of Dengue in China. Dengue is a major public health problem in southern China. In recent years, the epidemic interval of Dengue outbreaks in southern China has become shorter and the epidemic area is expanding. Because Dengue epidemics coincide with rapid urbanization in China as a result of economic development, it has been suggested that urbanization creates favorable conditions for the survival and reproduction of Dengue vectors and for the transmission of Dengue virus. This application tests the central hypothesis that environmental changes resulting from urbanization affect the biology and vectorial capacity of Aedes albopictus, the major Dengue vector in southern China. We will further examine the molecular epidemiology of the Dengue virus in urban areas for major outbreaks in Guangzhou city in the past two decades. The long-term goal of this research is to determine the mechanisms of Dengue epidemics in urban environments and to develop effective prevention and control methods. We have designed the following two specific aims. First, we will determine the impact of urbanization on the larval and adult ecology of Aedes albopictus mosquitoes, the sole Dengue vector in the Guangzhou area where the present study will be conducted. This aim will test the hypothesis that urbanization creates favorable conditions for the survivorship and development of Aedes albopictus larvae and subsequently, increases the abundance of the Dengue vector. Second, we will determine the transmission patterns of Dengue virus in urban environments. This aim will test the hypothesis that Dengue outbreaks are associated with the introduction and circulation of new serotypes or genotypes of Dengue virus, and that vector competence of Ae. albopictus varies among Dengue viral serotypes and genotypes, and thus the most favored DENV serotype/genotype may become the epidemic type. The proposed research takes advantage of the unique Dengue epidemiological and vector population situations in Guangzhou, China where frequent Dengue outbreaks have occurred and Ae. albopictus is actively breeding in the urban environment. This research will significantly enhance our understanding of Dengue transmission in urban areas, and contribute to the development of effective surveillance and control programs of Dengue in China. PUBLIC HEALTH RELEVANCE: Dengue causes a major public health problem in China; however the mechanisms for increased frequencies and magnitude of Dengue are not clear. The present proposal will use to test the central hypothesis that environmental changes resulting from urbanization affect the biology and vectorial capacity of Ae. albopictus, the major vector of Dengue virus in southern China. The result of this research will be useful to determine the mechanisms of Dengue epidemics and develop effective prevention and control methods for Dengue.

描述（由申请人提供）：城市化对媒介生物学的影响和中国登革热的传播。 登革热是中国南部的主要公共卫生问题。近年来，中国南部登革热爆发的流行间隔已变短，流行病地区正在扩大。由于登革热的流行与经济发展后中国的快速城市化相吻合，因此有人提出，城市化为登革热媒介的生存和繁殖以及登革热病毒的传播带来了有利的条件。该申请检验了一个中心假设，即城市化导致的环境变化会影响中国南部主要的登革热载体艾德斯白菜的生物学和矢量能力。在过去的二十年中，我们将进一步研究城市地区登革热病毒的分子流行病学。这项研究的长期目标是确定城市环境中登革热流行的机制，并开发有效的预防和控制方法。我们设计了以下两个特定目标。首先，我们将确定城市化对伊蚊蚊子的幼虫和成人生态的影响，伊蚊蚊子是将在本研究进行的广州地区的唯一登革热媒介。该目标将检验以下假设：城市化为幼虫的生存和发展带来了有利的条件，随后增加了登革热载体的丰度。其次，我们将确定城市环境中登革热病毒的传播模式。该目标将检验以下假设：登革热爆发与登革热病毒的新血清型或基因型以及AE的载体能力的引入和循环有关。登革热病毒血清型和基因型之间的白化病有所不同，因此最有利的DENV血清型/基因型可能成为流行病类型。拟议的研究利用了中国广州的独特登革热流行病学和媒介种群情况，那里发生了频繁的登革热爆发和AE。白化病正在城市环境中积极繁殖。这项研究将大大增强我们对城市地区登革热传播的理解，并有助于开发中国登革热的有效监视和控制计划。 公共卫生相关性：登革热在中国引起了一个重大的公共卫生问题；但是，登革热频率和幅度增加的机制尚不清楚。本提案将用于检验中心假设，即城市化导致的环境变化会影响AE的生物学和媒介能力。白化病，中国南部的登革热病毒的主要载体。这项研究的结果将有助于确定登革热流行的机制，并为登革热开发有效的预防和控制方法。