Impacts of Urbanization on Vector Biology and Transmission of Dengue in China

中国城市化对媒介生物学和登革热传播的影响

• 批准号: 10171758
• 负责人: Xiaoguang Chen
• 金额: $ 13.29万
• 依托单位: SOUTHERN MEDICAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10171758
• 关键词: Acute; Aedes; Biological Markers; Biology; CRISPR/Cas technology; Candidate Disease Gene; Chemicals; China; Cities; Code; Communicable Diseases; Country; Culicidae; Data; Dengue; Dengue Fever; Dengue Virus; Detection; Disease Outbreaks; Drug Metabolic Detoxication; Ecology; Elements; Epidemic; Epidemiology; Gene Mutation; Genes; Grant; Impact evaluation; Insecticide Resistance; Insecticides; Knowledge; Lead; Metabolic; Methods; Molecular; Mosquito Control; Mutation; Outcome; Pest Control; Pharmaceutical Preparations; Phenotype; Population; Population Density; Population Genetics; Predisposition; Prevention; Prevention strategy; Province; Public Health; RNA Interference; Resistance; Resistance development; Rural; Site; Sodium Channel; Techniques; Testing; Urbanization; Vaccines; Vectorial capacity; base; detection method; disorder prevention; experience; genetic analysis; life history; pressure; programs; prospective; pyrethroid; resistance gene; resistance mechanism; rural environment; success; survivorship; tool; trait; transcriptome; transmission process; urban area; urban setting; vector; vector competence; vector control; vector mosquito; voltage

Project Summary Title: Impacts of Urbanization on Vector Biology and Transmission of Dengue in China Dengue fever is an acute infectious disease caused by the dengue virus and transmitted by Aedes mosquitoes. Despite the intense control program in China, major dengue outbreaks have recently occurred in the urban area of Southern China. Control of mosquito populations is the only available strategy for prevention of dengue because there are no effective drugs for dengue. The use of chemical insecticides represents the most important element of vector control for dengue in China and worldwide. Our preliminary data indicates a rapid rise of pyrethroid resistance in the dengue vectors in urban areas of southern China. This competing renewal application will test the central hypothesis that frequent dengue outbreaks and intensive insecticide use in the urban environment lead to an emergence and spread of insecticide resistance in the dengue vector, which in turn increases vector population density and vectorial capacity for dengue. We proposed three interlinked specific aims: 1) to determine resistance level of dengue vector populations in urban and rural environments, 2) to develop new molecular tools for insecticide resistance surveillance through a better understanding of resistance mechanisms, and to conduct molecular surveillance of insecticide resistance in urban and rural environments, and 3) to determine the effect of insecticide resistance on mosquito survivorship, vector competence and vectorial capacity in urban and rural environments. We will focus on Aedes albopictus, a highly invasive species and the most important dengue vector in Southern China. The knowledge and tools from this project will help in guiding the selection of insecticides for dengue vector control, facilitate insecticide resistance surveillance and management, and enhance our understanding of dengue epidemiology in the urban environment where insecticide resistance is rapidly increasing.

项目摘要 标题：城市化对向量生物学和 中国登革热的传播 登革热是一种由登革热病毒引起的急性传染病， 由艾德斯蚊子传输。尽管在中国有强烈的控制计划，但 登革热爆发最近发生在中国南部地区。控制 蚊子种群是预防登革热的唯一可用策略，因为 没有有效的登革热药物。化学杀虫剂的使用代表 中国和全球登革热的向量控制的最重要元素。我们的 初步数据表明，登革热载体中拟除虫菊酯抗性的迅速上升 中国南部的城市地区。该竞争续约申请将测试 中心假设是频繁出现登革热和强化杀虫剂的使用 在城市环境中导致杀虫剂的出现和传播 登革热媒介的抗性又增加了载体种群 登革热的密度和矢量能力。我们提出了三个相互联系的特定 目的：1）确定城市和农村中登革热媒介种群的抵抗水平 环境，2）开发用于杀虫剂耐药性监测的新分子工具 通过更好地理解电阻机制，并进行分子 在城市和农村环境中对杀虫剂耐药性的监视，以及3） 确定杀虫剂耐药性对蚊子生存，载体的影响 城市和农村环境中的能力和媒介能力。我们将重点关注 艾德（Aedes botictus），高度入侵物种和最重要的登革热载体 中国南部。该项目的知识和工具将有助于指导 选择用于登革热媒介控制的杀虫剂，促进杀虫剂耐药性 监视和管理，并增强我们对登革热流行病学的理解 在城市环境中，抗杀虫剂的性能正在迅速增加。