Translational Drug Abuse Prevention Center

转化药物滥用预防中心

基本信息

批准号：
8554446
负责人：
PATRICIA CHAMBERLAIN
金额：
$ 146.92万
依托单位：
OREGON SOCIAL LEARNING CENTER, INC.
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-07-15 至 2018-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8554446
关键词：
Address Adolescent Adopted American Americas Applications Grants Area Behavior Behavioral Cellular Phone Characteristics Child Child Welfare Data Decision Making Development Disadvantaged Drug abuse Drug usage Evidence based intervention Evidence based practice Evidence based program Exposure to Failure Family Female Adolescents Funding Future Goals Grant HIV risk Homelessness Imprisonment Individual Intervention Investigation Knowledge Knowledge Discovery Lead Leadership Learning Life Measures Mental Health Mentors Methodology Methods Minority Modeling National Institute of Drug Abuse Neurobiology Oregon Outcome Pathway interactions Pear Pilot Projects Policies Policy Maker Population Pregnancy in Adolescence Prevention Research Prevention strategy Preventive Intervention Process Psychology Recording of previous events Research Research Design Research Infrastructure Research Personnel Research Project Grants Resources Risk Risk Behaviors Risk Factors Science Scientific Advances and Accomplishments Scientist Seeds Services Sex Behavior Shapes Social Environment Social Welfare Societies System TNFRSF5 gene Techniques Technology Testing Time Training Training Activity Translational Research Universities Work Youth affective neuroscience base career community based service cost effective drug abuse prevention early adolescence effectiveness trial efficacy trial experience foster care implementation science improved innovation knowledge base maltreatment multidisciplinary neuroimaging next generation novel physical conditioning programs public health relevance ranpirnase scale up social social neuroscience statistics success systems research working group

项目摘要

DESCRIPTION (provided by applicant): The purpose of the proposed P50 Center, Translational Drug Abuse Prevention (TDAP), is to serve as a national resource for cutting-edge, multidisciplinary, scientifically innovative and synergistic Type I and II translational prevention research in drug abuse that seeds future research, practice, and policy in the child welfare system (CWS). Children and adolescents with involvement in the CWS, and those adopted following CWS involvement, are at greatly elevated risk for drug use, HIV-risk, and associated problems including delinquency and poor mental health. The TDAP Center will extend our previous work on drug abuse prevention and broaden the reach and impact of our basic and intervention work in this area through an integrated program of research spanning Type I and Type II prevention research that will increase our understanding in three key areas that have direct effects on CWS policy and practice: (1) Understanding of underlying mechanisms and processes associated with exposure to high levels of early life adversity, and specific to risky decision-making in certain social contexts that are common for CWS youth during early adolescence; (2) reducing the high rates of drug use and engagement in HIV-risk behaviors in adolescent girls in the CWS via novel preventive intervention strategies; and (3) identifying methods for implementing extant evidence-based interventions into CWS real-world settings with high fidelity and empirically measuring implementation success/failure in the context of a public child welfare system-initiated reform. The above Research Components will be supported by a Methodology and Statistics Core that will facilitate integrated qualitative and quantitative analyses of the incoming data, as well as integrate the new data with our large existing data resource of CWS studies. A Pilot and Training Core will support the development of small-scale studies designed to lead to innovative, new independent research projects led by early career, and minority researchers in the area of prevention of drug abuse and HIV-risk in the CWS. Finally, an Administrative Core will provide leadership within the Center, interface with an external Advisory Board comprised of experts in CWS leaders and policy makers, and facilitate training and mentoring of Early Career Scientists.

描述（由申请人提供）：拟议的p50中心的目的，即翻译药物滥用预防（TDAP），是作为尖端，多学科，科学创新和I型和II型和II型预防药物滥用研究的国家资源，以播种儿童福利系统中未来研究，实践和政策的药物滥用研究（CWS）。参与CWS的儿童和青少年，以及CWS参与后通过的儿童和青少年，吸毒，HIV风险以及相关问题在内的风险大大提高，包括犯罪和精神健康不良。 TDAP中心将通过一项研究跨越I型和II型预防研究的综合计划来扩展我们先前在预防药物滥用预防方面的工作，并扩大我们在该领域的基本和干预工作的影响力和影响，这将在三个关键领域中提高我们对CWS政策和实践有直接影响的关键领域的理解：（1）与早期生活的常规范围以及对较高层次的潜在态度相关的基础和过程的理解，以及对早期寿命的含量，以及特定级别的生命范围，以及特定级别的生命范围，以及特定级别的生命范围，以及特定级别的生命范围，以及对较高的层次的影响。青春期初期；（2）通过新颖的预防性干预策略，降低了CWS青春期女孩的毒品使用率和参与率高；（3）确定在公共儿童福利系统启动的改革的背景下，以高忠诚度和经验测量实施成功/失败的方法来实施现有证据的干预措施，以高忠诚度和经验衡量实施成功/失败。上述研究组件将得到一种方法和统计核心的支持，该方法将促进对传入数据的综合定性和定量分析，并将新数据与我们的大量CWS研究数据集成在一起。飞行员和训练核心将支持小型研究的发展，旨在导致以早期职业生涯领导的创新的，新的独立研究项目，以及预防CWS药物滥用和HIV风险领域的少数族裔研究人员。最后，行政核心将在中心内提供领导力，与由CWS领导者和政策制定者专家组成的外部咨询委员会的交互，并促进对早期职业科学家的培训和指导。