Catalytic C-C Activation: A "Cut and Sew" Approach to Bridged and Fused Rings

催化 C-C 激活：桥接环和熔合环的“裁剪和缝合”方法

• 批准号: 8614748
• 负责人: Guangbin Dong
• 金额: $ 28.61万
• 依托单位: UNIVERSITY OF TEXAS AT AUSTIN
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8614748
• 关键词: Alder plant; Alkenes; Biological; Biological Factors; Carbon; Cleaved cell; Complex; Coupling; Data; Development; Economics; Funding; Goals; Ketones; Knowledge; Lead; Length; Literature; Methods; Molecular Structure; Natural Product Drug; Outcome; Pharmacologic Substance; Play; Preparation; Reaction; Research; Skeleton; Structure; System; Transition Elements; Work; base; catalyst; chemical synthesis; cyclic ketone; cycloaddition; drug discovery; improved; novel; public health relevance; scaffold; success; tool

DESCRIPTION (provided by applicant): We are engaged in the first systematic efforts to exploit catalytic ketone/unsaturated moiety coupling via C-C activation. Our objective, in the proposed funding period, is to develop a "Cut and Sew" strategy for the efficient synthesis of bridged/fused ring systems via catalytic C-C activation, which includes 1) regular "Cut and Sew": Rh- or Co-catalyzed intramolecular carboacylation with both strained and unstrained cyclic ketones; 2) decarbonylative "Cut and Sew": catalytic intramolecular couplings between cyclic ketones and unsaturated moieties with CO extrusion. The research proposed is expected to provide a general and unified strategy to build complex skeletons, found in numerous natural products and drugs, from simple starting materials.

描述（由申请人提供）：我们从事第一个系统的努力，以通过C-C激活来利用催化酮/不饱和部分偶联。我们的目标是在拟议的资金期间，是通过催化C-C激活制定“切割和缝制”策略，以有效合成桥接/融合的环系统，其中包括1）常规“切割和缝制”：RH-或共催化的分子内碳释放式旋转，并具有紧张和未经训练的环状酮基因； 2）脱轴词“切割和缝制”：循环酮和不饱和部分的催化分子内耦合，并带有CO挤出。预计提出的研究将提供一般而统一的策略，以从简单的起始材料中建立许多天然产品和药物中发现的复杂骨骼。