Catalytic C-C Activation of Ketones - Renewal 01

酮的催化 C-C 活化 - 更新 01

• 批准号: 10447220
• 负责人: Guangbin Dong
• 金额: $ 8.09万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10447220
• 关键词: Biological; Carbon; Catalysis; Chemicals; Chemistry; Cobalt; Complex; Funding; Goals; Hydrogen Bonding; Indole Alkaloids; Ketones; Laboratories; Mediating; Methods; Natural Product Drug; Oxidation-Reduction; Process; Research; Skeleton; Structure; Surface; System; Transition Elements; Work; analog; bioactive natural products; carbon skeleton; catalyst; cofactor; functional group; interest; novel; public health relevance; small molecule; success

Abstract: We are engaged in the systematic efforts to exploit catalytic carbon–carbon (C−C) bond activation for developing new, general and synthetically useful methods. Our objective, in the proposed funding period, is to focus on C−C activation of ketones, as ketone moieties are ubiquitously found in feedstock chemicals, synthetic building blocks and bioactive compounds. Specifically, we will: (i) expand the scope and utilities with activation of strained ketones for constructing complex ring systems, (ii) enable new and broadly applicable transformations with unstrained ketones in an atom-economical fashion, and (iii) explore a new activation mode that can shift the paradigm for ketone activation. The research proposed is expected to simplify synthesis through new strategic bond disconnections, allow for editing skeletons of complex molecules under redox-neutral conditions, and offer a byproduct-free approach to access organic building blocks.

摘要：我们从事有系统的努力来利用催化碳 - 碳（C-C） 开发新的，一般和合成有用的方法的键激活。我们的目标，进 拟议的资金期限是集中于C-C激活酮，因为酮部分是 在原料化学物质，合成的构件和生物活性化合物中无处不在。 具体而言，我们将：（i）通过激活应变的酮的范围和实用程序扩大范围和实用程序 构建复杂的环系统，（ii）启用新的和广泛适用的转换 以原子经济方式未经培养的酮，（iii）探索一种新的激活模式 可以移动酮酮激活的范例。预计提出的研究将简化 通过新的战略键断开的合成，允许编辑复杂的骨骼 氧化还原条件下的分子，并提供无副产品的访问方法 有机构件。