Novel strategies for stroke rehabilitation (planning grant)

中风康复新策略（规划拨款）

• 批准号: 8319998
• 负责人: ADRIANA B CONFORTO
• 金额: $ 2.92万
• 依托单位: FUNDACAO FACULDADE DE MEDICINA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-15 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8319998
• 关键词: Animals; Applications Grants; Biomedical Engineering; Brazil; Cerebrovascular Disorders; Clinic; Clinical; Collaborations; Country; Education; Electric Stimulation; Equipment; Funding; Future; Grant; Healthcare; Hospitals; Human; Human Resources; Income; Independent Living; Institution; Intervention; Laboratories; Mentors; National Institute of Neurological Disorders and Stroke; Neurologic; Neurons; Neurosciences; Operative Surgical Procedures; Physiology; Protocols documentation; Rehabilitation therapy; Research; Research Infrastructure; Research Personnel; Staging; Stroke; Structure; Testing; Training; Training Programs; United States; United States National Institutes of Health; Universities; Work; design; disability; evidence base; experience; global health; neuroregulation; neurosurgery; novel strategies; professor; programs; restoration; skills; stroke rehabilitation

DESCRIPTION (provided by applicant): Title: Novel strategies for stroke rehabilitation Cerebrovascular disease is the #1 cause of disability in western countries. The catastrophic burden of stroke and the scarcity of evidence-based rehabilitation interventions represent a major challenge to global health care. There is a gap between the massive impact of disability from stroke, studies in animals demonstrating "rewiring" of neuronal circuits and availability of neurorehabilitative strategies to restore independent living in the clinical domain. Basic infrastructure to implement research in stroke rehabilitation has been developed at the Neurostimulation Laboratory at Hospital das Clmnicas/ Sao Paulo University, Brazil, in great part due to a previous NIH-funded grant. However there is a lack of skilled human resources to move the research forward. This grant proposal aims to plan a training program that will provide skills in neuroscience, stroke rehabilitation, neuromodulation and biomedical engineering that will nurture novel strategies to decrease disability from stroke. The P.I., Dr. Conforto, chief of the Neurostimulatation Laboratory, will collaborate with Dr. Leonardo Cohen, a senior researcher that leads the Human Cortical Physiology and Stroke Rehabilitation Section at Intramural NINDS, with Dr. P. Hunter Peckham, a distinguished researcher and pioneer on functional electrical stimulation, who is Professor of Biomedical Engineering at the Case Western Reserve University and with Dr. Andre Machado, Director of the Center for Neurological Restoration and Assistant Professor of Surgery in the Neurosurgery Department at the Cleveland Clinic, who leads rehabilitation protocols and who was mentored by Dr. Conforto at Sao Paulo in the past. In addition, Dr. Suely Marie, an eminent senior Brazilian researcher at Sao Paulo University with extensive experience in training research personnel and in participating in multicenter collaborations, will assist the P.I. in adapting the training program to local conditions. During the grant, researchers from the institution in the middle-income country (Brazil) and the high-income institutions in the United States will work together to identify creative, effective mechanisms to enhance research capability at the Neurostimulation Laboratory. We will design and test a preliminary, structured training program that includes theoretical and practical activities, and that until now has never been implemented in the middle-income institution. Adjustments will be made, and results of the program will be thoroughly and objectively evaluated to prepare a comprehensive training program for a future D-43 grant application proposal. The collaboration between Sao Paulo University, Intramural NINDS, Case Western Reserve University and Cleveland Clinic will set the stage for advancing education in non invasive cortical neuromodulation and biomedical engineering, needed to ripen strategies for stroke rehabilitation. Equipment and facilities are available at the middle-income country institution that will provide full support to this planning grant proposal.

描述（由申请人提供）：标题：中风康复脑血管疾病的新型策略是西方国家残疾的第一起原因。中风的灾难性负担和基于证据的康复干预措施的稀缺是对全球医疗保健的主要挑战。中风对残疾的巨大影响之间存在差距，对动物的研究表明神经元回路“重新布线”与神经居住策略的可用性，以恢复生活在临床领域中的独立生活。由于以前的NIH资助的赠款，在巴西Das Clmnicas/ Sao Paulo University医院的神经刺激实验室已经开发了实施中风康复研究的基本基础设施。但是，缺乏熟练的人力资源来推动研究的前进。该赠款提案旨在计划一项培训计划，该计划将提供神经科学，中风康复，神经调节和生物医学工程的技能，该计划将培养新型策略以减少中风的残疾。 The P.I., Dr. Conforto, chief of the Neurostimulatation Laboratory, will collaborate with Dr. Leonardo Cohen, a senior researcher that leads the Human Cortical Physiology and Stroke Rehabilitation Section at Intramural NINDS, with Dr. P. Hunter Peckham, a distinguished researcher and pioneer on functional electrical stimulation, who is Professor of Biomedical Engineering at the Case Western Reserve University and with Dr. Andre马查多（Machado），神经恢复中心主任，克利夫兰诊所神经外科部门的外科助理教授，他领导康复方案，并在过去的圣保罗（Sao Paulo）康德托（Conforto）博士指导。此外，圣保罗大学（Sao Paulo University）著名的巴西高级研究员Suely Marie博士在培训研究人员和参加多中心合作方面拥有丰富的经验，将协助P.I.将培训计划适应当地条件。在赠款期间，来自中等收入国家（巴西）机构和美国高收入机构的研究人员将共同努力，以确定创造性，有效的机制，以增强神经刺激实验室的研究能力。我们将设计和测试包括理论和实际活动在内的初步，结构化的培训计划，到目前为止，该计划从未在中等收入机构中实施。将进行调整，该计划的结果将进行彻底和客观的评估，以准备未来的D-43赠款申请建议的全面培训计划。圣保罗大学，壁内Ninds，Case Western Reserve University和Cleveland Clinic之间的合作将为促进非侵入性皮质神经调节和生物医学工程的教育奠定阶段，以成熟中风康复策略。中等收入乡村机构提供设备和设施，可为该计划赠款提案提供全力支持。