Translational SPECT/CT Imaging System

平移 SPECT/CT 成像系统

• 批准号: 10424888
• 负责人: Albert J Sinusas
• 金额: $ 162.67万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10424888
• 关键词: Animal Experimentation; Animals; Applications Grants; Biomedical Engineering; Blood flow; Cadaver; Cardiac; CdZnTe; Clinical Research; Complement; Disease; Environment; Equipment; Evaluation; Funding; Grant; Healthcare; Human; Hybrids; Image; Institution; Internal Medicine; Isotopes; Molecular Target; Morphologic artifacts; Motion; Operative Surgical Procedures; Pilot Projects; Positioning Attribute; Positron-Emission Tomography; Radioisotopes; Research Personnel; Resolution; Resources; Scanning; System; Technology; Time; Translational Research; United States National Institutes of Health; Universities; X-Ray Computed Tomography; attenuation; base; biomedical imaging; clinical center; clinical investigation; detector; heart motion; imaging facilities; imaging system; improved; instrument; instrumentation; kinetic model; medical schools; molecular imaging; radiological imaging; radiotracer; respiratory; single photon emission computed tomography; whole body imaging; working group

Summary This high-end shared instrument grant proposal is to replace the existing hybrid SPECT/CT scanner (Discovery NMCT570c, GE Healthcare) that was purchased in 2010 with a shared instrumentation grant (1 S10 RR025555-01) entitled, “Hybrid Volumetric SPECT/CT Imaging System”, with a new SPECT/CT that has 12 cadmium zinc telluride (CZT) detector modules in a unique 360° configuration with adaptable detector position and angle. This new CZT-based SPECT technology is capable of focused or whole-body imaging and will be applied for radionuclide targeted molecular imaging in larger animals in evaluation of a wide variety of diseases. The new CZT detector system will provide improved sensitivity and spatial resolution, bringing the SPECT technology closer to that of PET. The proposed hybrid scanner will facilitate correction for errors attributed to attenuation, scatter, partial volume effects, and radiotracer crosstalk during dual isotope acquisitions facilitating quantitative SPECT radiotracer-based molecular imaging. The high sensitivity of the technology will also enable ultra-fast dynamic SPECT imaging, which should prove to be extremely valuable for determining the biokinetics of new targeted radiotracers and allows for the determination of absolute blood flow through established kinetic modeling approaches. The high sensitivity also allows for shorter scan times as well as respiratory and cardiac gating which will minimize the possibility of subject and/or cardiac motion and therefore reduce motion related artifacts. The proposed system will enhance our established translational facilities for imaging of both small and large animals, human cadavers, and facilitate translational research at our institution. The CZT-based SPECT/CT imaging system will support the needs of multiple current NIH funded investigators at Yale University School of Medicine, from the Departments of Internal Medicine, Radiology & Biomedical Imaging, Surgery, and from the Department of Biomedical Engineering at Yale University as well as investigators at multiple other academic institutions throughout the US. The user group works on a variety of projects, which would utilize different features of the proposed equipment. The upgraded hybrid SPECT/CT imaging system will become an integral part of the Yale Translational Imaging Center (Y- TRIC), which has co-located large animal holding and surgery facilities with state-of-the-art imaging resources for translational animal research. This center will nicely complement our current Yale Center for Clinical Investigation (YCCI), which has been repeatedly funded by an NIH CTSA grant for establishing an integrated environment for clinical and translational research. Funds will be available through the YCCI to fund pilot projects from new investigators to assure expanded utilization of the system.

概括 这个高端共享的工具赠款提案是取代现有的混合spect/ct扫描仪（发现 NMCT570C，GE Healthcare）于2010年购买了共享仪器赠款（1 S10 RR025555-01）标题为“混合体积SPECT/CT成像系统”，具有12个新的SPECT/CT 在独特的360°构型中具有适应性探测器位置 和角度。这项新的基于CZT的SPECT技术能够专注或全身成像，并且将是 在较大的动物中应用射线循环的靶向分子成像，以评估多种多样的 疾病。新的CZT检测器系统将提供提高的灵敏度和空间分辨率，从而带来 SPECT技术更接近宠物。拟议的混合动力扫描仪将有助于校正错误 归因于双同位素期间的衰减，散射，部分体积效应和radiotracer串扰 支持基于定量SPECT radiotracer的分子成像的采集。高灵敏度 技术还将启用超快速的动态SPECT成像，这应该被证明是极有价值的 用于确定新的靶向放射性示踪剂的生物动力学，并允许确定绝对血液 通过已建立的动力学建模方法流动。高灵敏度还可以缩短扫描时间 以及呼吸道和心脏走廊，这将最大程度地减少受试者和/或心脏运动的可能性 因此减少与运动相关的伪影。拟议的系统将增强我们既定的翻译 大小动物，人尸体的成像的设施，并促进转化研究 我们的机构。基于CZT的SPECT/CT成像系统将支持多个电流NIH的需求 内科部门的耶鲁大学医学院的研究人员， 放射学和生物医学成像，手术以及耶鲁大学生物医学工程系 全美其他多家学术机构的大学以及研究人员。用户组 从事各种项目，这些项目将利用所提出的设备的不同功能。升级 混合SPECT/CT成像系统将成为耶鲁翻译成像中心不可或缺的一部分（Y- Tric），已将大型动物持有和手术设施与最先进的成像资源共同合作 用于翻译动物研究。该中心将很好地完成我们当前的耶鲁临床中心 调查（YCCI），已由NIH CTSA赠款一再资助，以建立综合的 临床和翻译研究的环境。资金将通过YCCI提供资金以资助飞行员 从新研究人员来确保扩大系统利用的项目。