PHYSIOLOGY AND PATHOPHYSIOLOGY OF BASAL GANGLIA IN PARKINSON?S DISEASE

帕金森病基底节的生理学和病理生理学

• 批准号: 8173075
• 负责人: Erwin B. Montgomery
• 金额: $ 3.1万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173075
• 关键词: Acquired Stuttering; Alabama; Animals; Basal Ganglia; Brain; Computer Retrieval of Information on Scientific Projects Database; Computer Simulation; Data; Deep Brain Stimulation; Functional disorder; Funding; Grant; Hearing; Institution; Left; Macaca mulatta; Methodology; Methods; Microelectrodes; Modeling; Motor; Motor Cortex; Movement Disorders; Parkinson Disease; Parkinsonian Disorders; Physiology; Publications; Reporting; Research; Research Personnel; Resources; Services; Source; Speech; System; Thalamic structure; United States National Institutes of Health; Universities; Walkers; Wisconsin; Work; new technology; sensory cortex

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To use rhesus monkey (Macaca mulatta) models of Parkinsonism and deep brain stimulation (DBS) as a way to probe how the basal ganglia and the motor and sensory cortex act as a functioning unit. To develop and advance the methods of Epidural Motor Cortex Stimulation for movement disorders. Develop and advance computational modeling of the basal ganglia-thalamic-cortical system and the effects of DBS. We developed new technologies and methodologies for data accusation and analysis. We conducted microelectrode recordings in the basal ganglia-thalamic-cortical system in rhesus monkeys. This research used WNPRC Animal Services and WNPRC Operational Services (Shop). Note: Dr. Montgomery transferred to the University of Alabama during this reporting period. His related publications from his Wisconsin work are included in this report. PUBLICATIONS: Relief of acquired stuttering associated with Parkinson's disease by unilateral left subthalamic brain stimulation. Walker HC, Phillips DE, Boswell DB, Guthrie BL, Guthrie SL, Nicholas AP, Montgomery EB, Watts RL. J Speech Lang Hear Res. 2009 Dec;52(6):1652-7.PMID: 19951930.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 目的：使用帕金森病恒河猴（Macaca mulatta）模型和深部脑刺激（DBS）来探讨基底神经节以及运动和感觉皮层如何作为功能单元发挥作用。 开发和推进硬膜外运动皮质刺激治疗运动障碍的方法。 开发和推进基底节-丘脑-皮质系统的计算模型以及 DBS 的效果。 我们开发了用于数据指控和分析的新技术和方法。 我们在恒河猴的基底神经节-丘脑-皮质系统中进行了微电极记录。 本研究使用了 WNPRC 动物服务和 WNPRC 运营服务（商店）。 注：蒙哥马利博士于本报告期内转至阿拉巴马大学。他在威斯康星州工作的相关出版物包含在本报告中。 出版物： 通过单侧左丘脑底刺激缓解与帕金森病相关的获得性口吃。沃克 HC、菲利普斯 DE、博斯韦尔 DB、格思里 BL、格思里 SL、尼古拉斯 AP、蒙哥马利 EB、瓦茨 RL。 J Speech Lang Hear Res。 2009 年 12 月；52(6):1652-7.PMID：19951930。