PSYCHOSOCIAL DISRUPTION OF ESTRADIOL ACTION ON BEHAVIOR

雌二醇对行为的心理社会干扰

• 批准号: 8172465
• 负责人: DONNA J TOUFEXIS
• 金额: $ 4.39万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172465
• 关键词: Affect; Agonist; Anti-Anxiety Agents; Anxiety; Behavior; Behavioral; Computer Retrieval of Information on Scientific Projects Database; Data; Data Collection; Dose; Estradiol; Estrogen Receptors; Estrogens; Female; Funding; Grant; Institution; Macaca mulatta; Mediating; Outcome Measure; Oxytocin; Pharmaceutical Preparations; Prolactin; Psychosocial Stress; Pyrazoles; Research; Research Personnel; Resources; Serum; Source; Stress; Testing; United States National Institutes of Health; design; diarylpropionitrile; psychosocial; social

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The NIMH-funded project was begun in July 2009 to test the hypothesis that psychosocial stress, mediated by social subordination disrupts the prosocial and anxiolytic effects of estradiol in female rhesus monkeys. Studies initiated during the first year was design to determine effective dose ranges for estrogen receptor (ER) ¿ and (registered) agonists, propyl-pyrazole-triol (PPT) and diarylpropionitrile (DPN), respectively. Two doses of each were compared to two doses of estradiol on a range of estrogen-dependent outcome measures, including social and anxiety like behavior, serum levels of LH, oxytocin, prolactin, and CSF levels of oxytocin. Data collection was completed in Nov 2009 so analyses are underway. However, data to date suggest that dominant females have higher levels of oxytocin in serum and CSF and this is enhanced by estradiol and PPT. However, these drugs do not influence the lower levels of oxytocin in subordinates. These studies will greatly enhance our understanding of how stress adversely affects the behavioral efficacy of estradiol in females.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以出现在其他 CRISP 条目中 列出的机构是。 对于中心来说，它不一定是研究者的机构。 该项目由 NIMH 资助，于 2009 年 7 月启动，旨在测试以下假设：由社会服从介导的社会心理压力会破坏雌性恒河猴中雌二醇的亲社会和抗焦虑作用。第一年启动的研究旨在确定雌激素的有效剂量范围。受体 (ER) ¿和（注册）激动剂分别是丙基吡唑三醇（PPT）和二芳基丙腈（DPN）。 将每种剂量的两剂与两剂雌二醇的一系列雌激素依赖性结果指标进行比较，包括社交和焦虑样行为、血清 LH 水平、催产素、催乳素和脑脊液催产素水平。数据收集于 2009 年 11 月完成。然而，迄今为止的数据表明，占主导地位的女性在血清和脑脊液中具有较高水平的催产素，并且雌二醇和 PPT 可以增强这种水平，但是，这些药物不会影响较低的水平。这些研究将极大地增强我们对压力如何对女性雌二醇的行为功效产生不利影响的理解。