PSYCHOSOCIAL DISRUPTION OF ESTRADIOL ACTION ON BEHAVIOR

雌二醇对行为的心理社会干扰

• 批准号: 8357502
• 负责人: DONNA J TOUFEXIS
• 金额: $ 3.29万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357502
• 关键词: Affect; Anti-Anxiety Agents; Attenuated; Behavior; Behavioral; Body Size; Data; Data Analyses; Dose; Eating; Emotional; Estradiol; Estrogens; Exposure to; Female; Funding; Grant; Health; Hormones; Macaca mulatta; Manuscripts; Mediating; Metabolic; National Center for Research Resources; National Institute of Mental Health; Phenotype; Physiological; Primates; Principal Investigator; Psychosocial Stress; Research; Research Infrastructure; Resources; Social status; Source; Stress; Testing; United States National Institutes of Health; Work; cost; male; motivated behavior; neurochemistry; psychosocial; reproductive; research study; response; social; stressor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The NIMH-funded project was begun in July 2009 to test the hypothesis that psychosocial stress, mediated by social subordination, disrupts the prosocial and anxiolytic effects of estradiol in female rhesus monkeys. Thus far, we have collected data to further describe the phenotype of socially subordinate females. Changes in phenotype that were observed included: metabolic hormones, body size, reproductive parameters, behavior, neurochemistry, stress hormone response, and food intake. These data show that social subordination in female rhesus monkeys affects a number of phenotypes that impact behavioral and physiological health. In addition, Experiments 1A and 1B described in the application were initiated. This study investigated the dose-response effects of estradiol on sexual, affiliative, agonistic, and emotional behavior and how this is modified by social status. In the expression of affilative behaviors dominant females were significantly more responsive to the intermediate dose of estradiol than were subordinate females. Furthermore, the highest dose of estrogen increases afiilitative behavior in dominants but not subordinates. Female sexually motivated behavior showed a clear significant dose effect of estradiol with progressively higher rates of proceptive behaviors directed towards males with increasing doses of estradiol. This response to estradiol was significantly greater in dominant compared with subordinate females, regardless of dose. These data support our working hypothesis that continual exposure to social stressors, mediated by social subordination, attenuates the behavioral efficacy of estradiol in females. We expect data analysis for these studies to be completed in late January 2011 with several manuscripts submitted shortly thereafter.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 该项目由 NIMH 资助，于 2009 年 7 月开始，旨在测试以下假设：由社会从属关系介导的社会心理压力会破坏雌性恒河猴中雌二醇的亲社会和抗焦虑作用。到目前为止，我们已经收集了数据来进一步描述社会从属女性的表型。观察到的表型变化包括：代谢激素、体型、生殖参数、行为、神经化学、应激激素反应和食物摄入量。这些数据表明，雌性恒河猴的社会从属地位会影响许多影响行为和生理健康的表型。此外，启动了该申请中描述的实验1A和1B。这项研究调查了雌二醇对性行为、亲和行为、争斗行为和情绪行为的剂量反应效应，以及社会地位如何改变这种效应。在亲和行为的表达方面，占主导地位的女性对中等剂量雌二醇的反应明显比从属女性更敏感。此外，最高剂量的雌激素会增加统治者的亲和行为，但不会增加下属的依从行为。女性的性动机行为表现出明显的雌二醇剂量效应，随着雌二醇剂量的增加，针对男性的性行为发生率逐渐升高。无论剂量如何，与从属雌性相比，优势雌性对雌二醇的反应明显更大。这些数据支持我们的工作假设，即持续暴露于由社会从属介导的社会压力源会减弱女性雌二醇的行为功效。我们预计这些研究的数据分析将于 2011 年 1 月下旬完成，随后不久将提交几份手稿。