CRYSTAL STRUCTURE OF PGP3

PGP3 的晶体结构

• 批准号: 8169235
• 负责人: P J HART
• 金额: $ 1.4万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169235
• 关键词: Cells; Chlamydia; Chlamydia Infections; Computer Retrieval of Information on Scientific Projects Database; Cytosol; Disease; Funding; Genes; Grant; Health; Hour; Human; Infection; Inflammatory; Inflammatory Response; Institution; Open Reading Frames; Pathogenesis; Plasmids; Research; Research Personnel; Resources; Signal Pathway; Signal Transduction; Source; Structure; United States National Institutes of Health; Virulence Factors; pathogen

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Chlamydia represents a group of gram negative intracellular pathogens that are known to cause various health problems in humans. It is generally accepted that Chlamydia-induced diseases are due to host inflammatory responses caused by chlamydial infection. Several chlamydial species carry a 7.5 Kb cryptic plasmid. The plasmid encodes eight putative open reading frames (pORF). pORF5 encodes Pgp3 which is a virulence factor that is mainly detected in the cytosol of Chlamydia infected cells 12 hours after infection. Pgp3 is secreted by all chlamydial species that have the cryptic plasmid. It interacts with the host cell signaling pathway including the activation of host inflammatory genes. The structure of Pgp3 can provide valuable information to help understand the activation of the inflammatory response and chlamydial pathogenesis.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 衣原体代表一组革兰氏阴性细胞内病原体，已知会导致人类各种健康问题。人们普遍认为，衣原体引起的疾病是由于衣原体感染引起的宿主炎症反应所致。几种衣原体携带 7.5 Kb 的隐性质粒。该质粒编码八个假定的开放阅读框（pORF）。 pORF5 编码 Pgp3，Pgp3 是一种毒力因子，主要在感染后 12 小时在衣原体感染细胞的胞质溶胶中检测到。 Pgp3 由所有具有隐秘质粒的衣原体物种分泌。它与宿主细胞信号通路相互作用，包括激活宿主炎症基因。 Pgp3的结构可以提供有价值的信息，帮助了解炎症反应的激活和衣原体发病机制。