STRUCTURAL NEUROIMAGING CORE

结构神经影像核心

• 批准号: 8171126
• 负责人: TERRY L. JERNIGAN
• 金额: $ 0.95万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171126
• 关键词: Autopsy; Brain; Brain imaging; Cerebrum; Computer Retrieval of Information on Scientific Projects Database; Consultations; Data; Development; Diffusion; Disease; Functional Magnetic Resonance Imaging; Functional disorder; Funding; Generations; Grant; HIV encephalitis; Image; Image Analysis; Institution; Laboratories; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Maps; Measurable; Mentorship; Methods; Modality; Monitor; Nature; Participant; Pilot Projects; Population; Research; Research Infrastructure; Research Personnel; Resources; Source; Structure; Students; Techniques; Training; Training Programs; United States National Institutes of Health; Work; brain morphology; brain tissue; in vivo; method development; neuroimaging; programs; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary objectives of this Core are: 1) To assist in characterizing study participants, by providing information about gross brain morphology, with a particular emphasis on neuroanatomical abnormalities present late in the capabilities to studies requiring detailed regional neuroanatomic characterization; 3) To support, with consultation; 3) To support, with consultation and generation of sMRI data for pilot studies, new research initiatives employing neuroimaging techniques, such as MR Spectroscopy (MRS), MR diffusion imaging, and functional MRI (fMRI); 4) To provide a liaison between HNRC investigators and two associated neuroimaging programs: (a) the Brain Image Analysis Laboratory (BIAL), a (REAP), a multi-investigator core infrastructure and training program focusing on applications of fMRI in dementing disorders (T. Jernigan, P.I.); 5) To provide mentorship, consultation, and training in neuroimaging to students and junior investigators affiliated with the HNRC. The Core will support ongoing work investigating the nature and regional distribution of HIV-related brain abnormalities measurable in vivo (with sMRI data), as well as new work aimed at developing more sensitive and more efficient means of monitoring HIV-related CNS dysfunction with other neuroimaging modalities (e.g., fMRI, MR Spectroscopy, etc.). The Core will also focus on new method development targeting the specific abnormalities present in this population, including the development of: more fully automated image-analytic methods for assessment of brain structure from MRI volumes; maps of the distribution of brain tissue anomalies associated with CDC-C3 status and ultimately, with autopsy-verified HIV encephalitis (HIVE); and more sophisticated methods for characterizing prevalent MRI abnormalities in cerebral white matter.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该核心的主要目标是： 1) 通过提供有关大脑大体形态的信息，协助表征研究参与者，特别强调在需要详细的区域神经解剖学特征的研究能力中后期出现的神经解剖学异常； 3）支持、咨询； 3) 通过咨询和生成用于试点研究的 sMRI 数据，支持采用神经影像技术的新研究计划，例如 MR 波谱 (MRS)、MR 扩散成像和功能 MRI (fMRI)； 4) 为 HNRC 研究人员和两个相关的神经影像项目之间提供联络：(a) 脑图像分析实验室 (BIAL)，一个 (REAP)，一个多研究者核心基础设施和培训项目，重点关注功能磁共振成像在痴呆症中的应用 ( T.杰尼根，P.I.）； 5) 为 HNRC 下属的学生和初级研究人员提供神经影像学方面的指导、咨询和培训。该核心将支持正在进行的研究体内可测量的与艾滋病毒相关的大脑异常的性质和区域分布（使用 sMRI 数据）的工作，以及旨在开发更灵敏和更有效的方法来监测与其他疾病相关的中枢神经系统功能障碍的新工作。神经影像学模式（例如功能磁共振成像、磁共振波谱等）。该核心还将专注于针对该人群中存在的特定异常的新方法开发，包括开发：更全自动的图像分析方法，用于根据 MRI 体积评估大脑结构；与 CDC-C3 状态以及最终与尸检证实的 HIV 脑炎 (HIVE) 相关的脑组织异常分布图；以及更复杂的方法来表征脑白质中常见的 MRI 异常。