Paracorporeal Ambulatory Assist Lung

体外动态辅助肺

• 批准号: 8459760
• 负责人: JAMES F. ANTAKI
• 金额: $ 68.82万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-02-15 至 2018-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8459760
• 关键词: Acute; Acute Disease; Adult Respiratory Distress Syndrome; Algorithms; American; Animals; Biocompatible Materials; Biomedical Engineering; Blood; Blood flow; Blood gas; Cannulations; Cause of Death; Chronic; Chronic Bronchitis; Chronic Obstructive Airway Disease; Chronic lung disease; Clinical; Complex; Computer Simulation; Development; Device Designs; Devices; Dysbarism; Environment; Extracorporeal Membrane Oxygenation; Failure; Fiber; Gases; Healthcare; Hemolysis; Heparin; Hospitals; Hour; Imagery; Injury; Lead; Life; Liquid substance; Lung; Lung Transplantation; Lung diseases; Mechanical ventilation; Membrane; Metabolic; Molecular; Optics; Oxygenators; Pathway interactions; Patients; Performance; Peripheral; Phosphorylcholine; Pulmonary Emphysema; Pulmonary artery structure; Pump; Recovery; Respiratory Insufficiency; Right atrial structure; Sheep; Siloxanes; Simulate; Surgeon; System; Testing; Tissue Engineering; Transplantation; Volutrauma; artificial lung; blood oxygenator; blood pump; cardiopulmonary system; design; disability; experience; improved; in vivo; meetings; novel; prototype; public health relevance; respiratory; respiratory assist; tool

DESCRIPTION (provided by applicant): Acute and chronic diseases of the lung remain major healthcare problems. Each year nearly 350,000 Americans die of some form of lung disease. Mechanical ventilation provides short-term support for these patients, but longer term support can lead to barotrauma, volutrauma, and other iatrogenic injuries, further exacerbating the respiratory insufficiency. Extracorporeal membrane oxygenation (ECMO) can provide longer term respiratory support but is complex and significantly limits a patient's mobility. This project will develop a compact respiratory assist device, the Paracorporeal Ambulatory Assist Lung (PAAL), to replace ECMO as a bridge to transplant or recovery in patients with acute and chronic lung failure. The PAAL is a fully integrated blood pump and gas exchange module and is designed for peripheral cannulation (e.g. jugular to femoral) or central cannulation (e.g. right atrium to pulmonary artery and worn on a holster or vest. The PAAL will be designed for longer-term respiratory support (1-3 months before change-out) at 70-100% of normal metabolic requirements, while pumping blood from 2 to 3.5 Liters/min. The specific aims of project are 1) To optimize the design and operational parameters of the PAAL to meet requirements for blood pumping, gas exchange, priming volume, and form factor; 2) To build PAAL prototypes along the design development pathway for bench characterization studies; 3) To improve hemocompatibility of the PAAL by exploring novel molecular Zwitterionic coatings; and 4) To perform acute and chronic animal studies in healthy sheep to demonstrate the in-vivo performance and hemocompatibility of the PAAL device and its interaction with the cardiopulmonary system.

描述（由申请人提供）：急性和慢性肺部疾病仍然是主要的医疗保健问题。每年有近 35 万美国人死于某种形式的肺部疾病。机械通气为这些患者提供短期支持，但长期支持可能导致气压伤、容量伤和其他医源性损伤，进一步加剧呼吸功能不全。体外膜肺氧合 (ECMO) 可以提供长期的呼吸支持，但很复杂，并且严重限制了患者的活动能力。这个项目 将开发一种紧凑型呼吸辅助设备，即体外动态辅助肺 (PAAL)，以取代 ECMO，作为急慢性肺衰竭患者移植或康复的桥梁。 PAAL 是完全集成的血泵和气体交换模块，设计用于外周插管（例如颈静脉至股动脉）或中央插管（例如右侧 心房至肺动脉并佩戴在皮套或背心上。 PAAL 旨在以正常代谢需求的 70-100% 提供长期呼吸支持（更换前 1-3 个月），同时泵血速度为 2 至 3.5 升/分钟。项目的具体目标是 1) 优化 PAAL 的设计和操作参数，以满足血液泵送、气体交换、预注量和外形尺寸的要求； 2) 沿着设计开发路径构建 PAAL 原型，以进行台架特性研究； 3）通过探索新型分子两性离子涂层来提高PAAL的血液相容性； 4) 在健康绵羊身上进行急性和慢性动物研究，以证明 PAAL 装置的体内性能和血液相容性及其与心肺系统的相互作用。