Biomarkers of Infertility

不孕不育的生物标志物

• 批准号: 8459875
• 负责人: Anne Zweifel Steiner
• 金额: $ 59.78万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-15 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8459875
• 关键词: Address; Age; Age of Onset; Aging; Anxiety; Assisted Reproductive Technology; Awareness; Biological Markers; Characteristics; Clinical; Cohort Studies; Coitus; Collection; Communities; Conceptions; Contraceptive methods; Data; Data Collection; Delayed Childbearing; Enrollment; Fertility; Follicle Stimulating Hormone; Future; General Population; Goals; Health behavior; Home environment; Hormones; Human Resources; Individual; Infertility; Institution; Intake; Internet; Lead; Length; Live Birth; Marketing; Measures; Menopause; Menstrual cycle; Methods; Modeling; Monitor; Online Systems; Oocytes; Outcome; Outcome Measure; Ovarian; Participant; Population; Pregnancy; Pregnancy Outcome; Pregnancy Tests; Pregnancy loss; Probability; Prospective Studies; Protocols documentation; Questionnaires; Recording of previous events; Reporting; Reproductive History; Research; Research Infrastructure; Risk; Sensitivity and Specificity; Serum; Spontaneous abortion; Surrogate Endpoint; System; Testing; Time; Training; Ultrasonography; Urine; Woman; age related; base; cohort; cost; data management; demographics; diaries; experience; follow-up; improved; innovation; meetings; mullerian-inhibiting hormone; parity; predictive modeling; proliferative phase Menstrual cycle; public health relevance; reproductive; toxicant; urinary

DESCRIPTION (provided by applicant): In the current era women often delay attempts to conceive to their thirties and forties, ages associated with higher rates of infertility due to reproductive aging. Despite variability in the age of onset of infertility, no validated markers exist to monitor an individual woman's fertility. The objective of this project is to examine the ability of markers of ovarian aging to predict infertility due to reproductive aging, with the long term goal to develop a model that projects individual loss of reproductive potential. We hypothesize that markers of ovarian aging are associated with natural fecundability (probability of conception per menstrual cycle), predictive of infertility, and associated with the probability of live birth. The proposed study will enroll 750 women from the community, who desire to conceive, and obtain baseline measures of ovarian aging: early follicular phase serum follicle stimulating hormone (FSH) and anti-m|llerian hormone (AMH). Participants will be actively followed throughout their attempts to conceive over the following twelve months. During that time, women will conduct standardized pregnancy testing and complete a daily and monthly diary for collection of detailed exposure data. Pregnancy follow-up will include ultrasound assessment for viability and a pregnancy outcome report. These methods will allow us to address our primary research aims: 1) Establish the marker of ovarian aging that best predicts infertility. To address this aim we will determine a) measures of association between FSH (in urine and serum) and AMH and lack of conception at 6 and 12 months and b) test characteristics (e.g. sensitivity & specificity) of each marker; 2) Develop a predictive model for age-related infertility, incorporating demographics, reproductive history, and markers of ovarian aging; and 3) Generate preliminary estimates of the association between markers of ovarian aging and miscarriage. Our study is innovative in its use of a population of unproven reproductive potential with previous access to contraception and at risk for reproductive aging. Results from this research, combined with research by others, will allow women to predict their current and future reproductive potential, ultimately allowing them more reproductive control.

描述（由申请人提供）：在当前时代，妇女经常延迟尝试构想自己的三十多岁和四十多岁，这是由于生殖衰老而导致的不孕症率较高的年龄。尽管不孕症发作时代的变化差异，但尚无经过验证的标记来监测单个妇女的生育能力。该项目的目的是检查卵巢衰老标志物预测由于生殖衰老而预测不育症的能力，其长期目标是开发一个模型，该模型投射个人失去生殖潜力的损失。我们假设卵巢衰老的标志物与自然的繁殖力（每一个月经周期的受孕概率）相关，可预测不育症，并且与活出生的概率有关。拟议的研究将招募来自社区的750名妇女，他们希望受孕并获得卵巢衰老的基线度量：早期卵泡相卵泡刺激激素（FSH）和抗M | llerian激素（AMH）。在接下来的十二个月中，将积极遵循参与者的想法。在此期间，妇女将进行标准化的妊娠测试，并完成每日和每月日记以收集详细的暴露数据。怀孕的随访将包括有关生存能力的超声评估和妊娠结局报告。这些方法将使我们能够解决我们的主要研究目的：1）建立最能预测不育的卵巢衰老的标志。为了解决这个目标，我们将确定a）fsh（尿液和血清中）与AMH之间的关联度量，以及在6和12个月时缺乏概念，以及b）每个标记的测试特征（例如灵敏度和特异性）； 2）为年龄相关的不育建立了一个预测模型，结合了人口统计学，生殖历史和卵巢衰老的标志； 3）产生对卵巢衰老和流产标记之间关联的初步估计。我们的研究在使用未经证实的生殖潜力的人群方面具有创新性，并以前获得避孕措施和有生殖衰老的风险。这项研究的结果以及其他人的研究将使妇女预测其当前和未来的生殖潜力，最终使她们更加生殖控制。