COBRE: OK MED RES FOUND: CORE IV: MRI IMAGING IN VIVO

COBRE：发现良好的医学研究成果：核心 IV：体内 MRI 成像

• 批准号: 8168456
• 负责人: Rheal A Towner
• 金额: $ 17.57万
• 依托单位: OKLAHOMA MEDICAL RESEARCH FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-08 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168456
• 关键词: Bioenergetics; Blood Vessels; Cardiovascular Diseases; Cardiovascular system; Centers of Research Excellence; Computer Retrieval of Information on Scientific Projects Database; Contrast Media; Core Facility; Disease; Foundations; Funding; Future; Grant; Histology; Image; Image Enhancement; Injury; Institution; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Medical Research; Metabolism; Microscopic; Modeling; Monitor; Monoclonal Antibodies; Oklahoma; Pathogenesis; Physiological; Rattus; Research; Research Personnel; Resolution; Resources; Source; Staging; Techniques; Tissues; Transgenic Mice; United States National Institutes of Health; in vivo; receptor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The general objective of the MRI/MRS Core facility is to provide non-invasive in vivo monitoring capabilities that can be used to assess morphological, physiological, pathophysiological and metabolic processes that occur during progressive stages of the pathogenesis of most diseases. A major focus of the MRI/MRS Core facility is to study the in vivo pathogenesis of various aspects of cardiovascular diseases in experimental transgenic mice or rat models. At least three of the 5 proposed projects will utilize the MRI/MRS Core facility as a major component and significantly benefit from magnetic resonance imaging (MRI) and/or magnetic resonance spectroscopy (MRS) studies. The remaining 2 proposed projects will possibly use MRI and/or MRS techniques in future proposed in vivo projects. As a result it is of the utmost importance that the MRI/MRS Core is established and that it directly interacts with each of the researchers respective to the proposed projects as discussed in further detail below. The core will be able to specifically provide in vivo (1) morphological assessment that will provide "microscopic" histology information in any cardiovascular-associated tissue or vascular vessel up to 100 #m resolution, (2) vascular specific images in the form of magnetic resonance angiography, (3) vascular flow velocity, (4) contrast agent image enhancement of cardiovascular pathogenesis with the use of recently-developed vascular-specific contrast agents, (5) contrast agent image enhancement of specific endothelial receptors that are involved in the pathogenesis of a cardiovascular disease using newlydeveloped monoclonal antibodies tagged with a contrast agent, and (6) metabolic processes relating to changes in either tissue injury or bioenergetics. The MRI/MRS Core facility will be established in the newly-proposed Oklahoma Medical Research Foundation MRI/MRS Facility located in the Bell Building, under the direction of Dr. Rheal A. Towner.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 中心，不一定是研究者的机构。 MRI/MRS 核心设施的总体目标是提供非侵入性体内监测功能，可用于评估大多数疾病发病机制进展阶段发生的形态、生理、病理生理和代谢过程。 MRI/MRS 核心设施的一个主要重点是研究实验转基因小鼠或大鼠模型中心血管疾病各个方面的体内发病机制。 5 个拟议项目中至少有 3 个将利用 MRI/MRS 核心设施作为主要组成部分，并显着受益于磁共振成像 (MRI) 和/或磁共振波谱 (MRS) 研究。其余 2 个拟议项目可能会在未来拟议的体内项目中使用 MRI 和/或 MRS 技术。因此，建立 MRI/MRS 核心并与拟议项目的每位研究人员直接互动至关重要，如下文进一步详细讨论。该核心将能够专门提供体内 (1) 形态学评估，提供任何心血管相关组织或血管的“微观”组织学信息，分辨率高达 100 #m，(2) 磁性形式的血管特定图像共振血管造影，(3) 血管流速，(4) 使用最近开发的血管特异性造影剂增强心血管发病机制的造影剂图像，(5) 所涉及的特定内皮受体的造影剂图像增强使用新开发的带有造影剂标记的单克隆抗体来研究心血管疾病的发病机制，以及（6）与组织损伤或生物能学变化相关的代谢过程。 MRI/MRS 核心设施将在新提议的俄克拉荷马州医学研究基金会 MRI/MRS 设施内建立，该设施位于贝尔大楼，由 Rheal A. Towner 博士负责。