Assess the Effects of Pre- and Postnatal exposure to the organophosphorus

评估产前和产后接触有机磷的影响

基本信息

批准号：
8391755
负责人：
Virginia A Rauh
金额：
$ 50.19万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-03-11 至 2015-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8391755
关键词：
10 year old 9 year old Adverse effects Affect Agriculture Air Pollutants Anatomy Animal Model Animals Area Attention Attention deficit hyperactivity disorder Behavioral Biological Markers Birth Weight Brain Brain Chemistry Brain region Chemicals Child Child Development Chlorpyrifos Clinical Cognition Cognitive Cohort Studies Development Developmental Delay Disorders Diagnosis Diazinon Diffusion Magnetic Resonance Imaging Documentation Dose Environmental Health Exposure to Fetal Growth Fiber Head Health Hippocampus (Brain)Hyperactive behavior Image Lateral Literature Longitudinal Studies Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Measures Memory Mental Depression Metabolism Modeling Motor Motor Activity N-acetylaspartate National Institute of Environmental Health Sciences Neurobiology Neurons Neuropsychological Tests Organophosphates Parietal Pattern Performance Pesticides Problem behavior Regression Analysis Relative (related person)Safety Sensorimotor functions Sensory Severities Structure Subgroup Symptoms TNFRSF5 gene Temporal Lobe Translational Research Umbilical Cord Blood United States Work association cortex base brain size brain volume cognitive function cohort early childhood inattention indexing inner city neurobehavioral neurodevelopment neuroimaging neuropsychological postnatal prenatal prenatal exposure prospective psychologic relating to nervous system respiratory response toxic organophosphate insecticide exposure white matter

项目摘要

DESCRIPTION (provided by applicant): The purpose of this study is to assess the effects of pre- and postnatal exposure to the organophosphorus (OP) pesticide chlorpyrifos (CPF) on neurobehavioral functioning in a cohort of inner-city children who have reached 9 years of age. This work builds on, and shares a cohort with, a prospective cohort study of ambient air pollutant effects on child development and respiratory health, being conducted by the Columbia Center for Children's Environmental Health (NIEHS R01 ES08977, P.I. Perera:11/01/03-10/31/08; 5 P01 ES09600/EPA RD-83214101, P.I. Perera, Co-I Rauh:11/01/03-10/31/08). Previous findings from the Children's Center study reveal adverse effects of prenatal exposure to CPF (validated with biomarkers in cord blood) on birth weight (Whyatt et al., 2004), cognitive and motor development, and neuro-behavioral problems at 3 years (Rauh et al., 2006). Affected neurobehavioral areas include attention and ADHD-- conditions with serious long-term clinical implications. Based on these findings, and evidence from the experimental literature showing long-term, possibly irreversible effects of CPF exposure on brain development and sensorimotor activity (Dam et al, 2000; Levin et al, 2002; Slotkin et al, 2005), we now propose to evaluate the longer-term neurodevelopmental effects of CPF in 300 9-year-old children. We will use Magnetic Resonance Imaging (MRI) to define the intermediary neurobiological effects of CPF exposure on the structure, metabolism, and anatomical connectivity of the brain in all 300 children. CPF was selected as a model for translational research because it is representative of the class of OP pesticides, well characterized, and well-studied in animals. Furthermore, agricultural and commercial uses continue, despite the 2001 residential ban by EPA. Specifically, we propose to: (1) assess the 9- year effects of prenatal and early childhood exposures to CPF on neurobehavioral (inattention, hyperactivity and depression) and neuropsychological functioning (attentional capacity, memory, impulse control and sensory motor functioning); and (2) assess the 9-year effects of prenatal and early childhood exposures to CPF on measures of brain structure (using anatomical MRI), brain chemistry/cellular metabolism (using magnetic resonance spectroscopy), and anatomical connectivity (using diffusion tensor imaging) in the same children.

描述（由申请人提供）：这项研究的目的是评估产前和产后暴露于有机磷（OP）农药毒性磷酸（CPF）对已经达到9岁的城市内部城市儿童中神经行为功能的影响。 This work builds on, and shares a cohort with, a prospective cohort study of ambient air pollutant effects on child development and respiratory health, being conducted by the Columbia Center for Children's Environmental Health (NIEHS R01 ES08977, P.I. Perera:11/01/03-10/31/08; 5 P01 ES09600/EPA RD-83214101, P.I. Perera，Co-I Rauh：11/01/03-10/31/08）。儿童中心研究的先前发现表明，在出生体重（Whyatt等，2004），认知和运动发育以及3年（Rauh等，2006）中，对CPF的暴露（用脐带血中的生物标志物证实）对出生体重（Whyatt等，2004），认知和运动发育以及神经行为问题的不利影响。受影响的神经行为区域包括注意力和多动症 - 具有严重长期临床意义的状况。基于这些发现以及实验文献的证据，表明CPF暴露对脑发育和感觉运动活性的长期，可能是不可逆的影响（Dam等，2000; Levin等，2002; Slotkin et al，2005），我们现在建议评估300岁9岁儿童CPF的长期神经发育影响。我们将使用磁共振成像（MRI）来定义CPF暴露对所有300名儿童中大脑的结构，代谢和解剖学连通性的中介神经生物学效应。 CPF被选为转化研究的模型，因为它代表了动物的特征性且经过充分研究的OP农药类别。此外，尽管EPA 2001年禁令，但农业和商业用途仍在继续。具体而言，我们建议：（1）评估CPF产前和幼儿期暴露于CPF对神经行为（不注意，多动症和抑郁症）以及神经心理学功能（注意力，记忆力，记忆力，冲动，冲动控制和感觉运动功能）的9年影响；（2）评估CPF产前和早期儿童期暴露于CPF对脑结构测量（使用解剖学MRI），脑化学/细胞代谢（使用磁共振光谱）和解剖学连接性（使用扩散张量成像）中的9年影响。