Air Pollution, Subclinical CVD and Inflammatory Markers in the SEARCH Cohort

搜索队列中的空气污染、亚临床 CVD 和炎症标志物

基本信息

批准号：
8495336
负责人：
ROBIN PUETT
金额：
$ 48.29万
依托单位：
UNIV OF MARYLAND, COLLEGE PARK
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-27 至 2015-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8495336
关键词：
19 year old Acute Address Adherence Adult Age Air Pollution Area Atherosclerosis Behavioral Biological Assay Biological Markers C-reactive protein Caliber Cardiovascular Diseases Cardiovascular Physiology Cardiovascular system Cause of Death Child Childhood Chronic Chronic Disease Collaborations Communities Coronary Data Demographic Factors Development Diabetes Mellitus Diet Disease Marker Environmental Exposure Environmental Pollutants Ethnic group Event Exhibits Exposure to Fibrinogen Functional disorder Gender Incidence Inflammation Inflammatory Insulin-Dependent Diabetes Mellitus Interleukin-6 Life Life Style Literature Long-Term Effects Measures Medial Medical Modeling Monitor Morbidity - disease rate Nutritional Persons Physical activity Physiologic pulse Plasma Population Proxy Race Recommendation Regimen Research Research Personnel Risk Risk Factors Role Sampling Socioeconomic Status Structure Target Populations Thick Time Vulnerable Populations Youth base cardiovascular disorder risk cardiovascular risk factor cohort cost diabetes management early onset experience geographic population high risk indexing inflammatory marker mortality non-diabetic particle racial and ethnic trafficking vascular inflammation

项目摘要

DESCRIPTION (provided by applicant): Type 1 diabetes mellitus is one of the leading chronic conditions among children and youth and its impact is increasing worldwide. Intense medical and nutritional management of the diabetic condition and any existing cardiovascular disease (CVD) risk factors is currently the key treatment approach. Yet even under rigorous adherence to these regimens, the onset of diabetes in childhood places this population at significantly increased long term risks of CVD morbidity and mortality. Research has shown that adults with diabetes are more susceptible than nondiabetics for increased CVD morbidity and mortality associated with exposures to outdoor air pollution. Very little research in this area has been conducted to examine whether children and youth with diabetes are similarly susceptible; however the inference seems reasonable, given that children typically spend more time outside and are more sensitive to environmental exposures. Since the early onset of type 1 diabetes increases CVD risks in adulthood, there is an urgent need to understand the role of air pollution exposures in this population. With representation of diverse racial and ethnic groups and geographically distinct areas of the US, as well as the availability of extensive, existing information on CVD risk factors, the SEARCH for Diabetes in Youth Study (SEARCH) offers an unprecedented opportunity to systematically study, in an efficient manner, the short and long-term effects of air pollution on cardiovascular risk. In this high-risk population of youth, we will examine the acute effects of air pollution exposures on inflammatory markers and measures of cardiovascular function, as well as the chronic effects of these exposures on cardiovascular structure. Understanding the role of air pollution on inflammation and subclinical CVD among children and youth with type 1 diabetes could have a major impact on treatment approaches and behavioral recommendations.

描述（由申请人提供）：1 型糖尿病是儿童和青少年中主要的慢性病之一，其影响在全球范围内日益增加。对糖尿病病情和任何现有心血管疾病 (CVD) 危险因素进行强化医疗和营养管理是目前的关键治疗方法。然而，即使严格遵守这些治疗方案，儿童期糖尿病的发病也会使这一人群的心血管疾病发病率和死亡率的长期风险显着增加。研究表明，成人糖尿病患者比非糖尿病患者更容易因暴露于室外空气污染而增加心血管疾病发病率和死亡率。该领域很少有研究来检验患有糖尿病的儿童和青少年是否同样容易受到影响；然而，考虑到儿童通常在户外花费更多时间并且对环境暴露更敏感，这一推论似乎是合理的。由于 1 型糖尿病的早期发病会增加成年后的 CVD 风险，因此迫切需要了解空气污染暴露对该人群的影响。由于具有美国不同种族和族裔群体以及不同地理区域的代表性，以及有关 CVD 危险因素的广泛现有信息的可用性，青少年糖尿病研究 (SEARCH) 提供了前所未有的机会来系统地研究以有效的方式研究空气污染对心血管风险的短期和长期影响。在这一高危青年人群中，我们将研究空气污染暴露对炎症标志物和心血管功能指标的急性影响，以及这些暴露对心血管结构的慢性影响。了解空气污染对 1 型糖尿病儿童和青少年炎症和亚临床 CVD 的影响可能会对治疗方法和行为建议产生重大影响。