Neurobehavioral and Neuroimaging Effects of Traffic Exposure in Children

交通暴露对儿童的神经行为和神经影像学影响

基本信息

批准号：
8500278
负责人：
Patrick H Ryan
金额：
$ 63.13万
依托单位：
CINCINNATI CHILDRENS HOSP MED CTR
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-07-01 至 2017-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8500278
关键词：
Address Age Air Pollution Allergic Disease Anatomy Architecture Aromatic Polycyclic Hydrocarbons Attention Behavior Behavioral Biological Markers Birth Blood - brain barrier anatomy Brain Carbon Cardiopulmonary Caregivers Characteristics Child Childhood Clinical Cognition Cohort Studies Complex Mixtures Data Development Diagnosis Disease Emotions Enrollment Environment Environmental Exposure Epidemiologic Studies Evaluation Exposure to Extrinsic asthma Family Fetus Functional disorder Future Health Home environment Hypersensitivity Image Analysis Immunologics Infant Inflammation Intelligence Knowledge Language Lead Learning Disabilities Link Location Magnetic Resonance Imaging Measures Memory Metabolic Metals Modeling Motor Myelin Neuraxis Neurotoxins Organ Outcome Particulate Matter Physiological Physiology Positioning Attribute Psychosocial Factor Public Health Questionnaires Recruitment Activity Regulation Reporting Research Respiratory System Risk Factors Schools Series Staging Structure Testing Time Tobacco smoke Toxic Environmental Substances Ultrafine air monitoring cofactor cognitive function cohort critical period data modeling disability early childhood executive function exhaust gray matter infancy innovation interest neural circuit neurobehavior neurobehavioral neurochemistry neurodevelopment neuroimaging neuroinflammation neurotoxic neurotoxicity novel particle prospective rapid growth trafficking white matter

项目摘要

DESCRIPTION (provided by applicant): The proposed study will address the hypothesis that exposure to traffic-related air pollution (TRAP) during critical periods of brain development is significantly associated with altered neurobehavior including deficits in cognition, attention, memory, executive function, global intelligence, neuromotor function, behavioral regulation, and altered brain anatomy and physiology. Exposure to environmental neurotoxicants prenatally and during early childhood has been associated with neurobehavioral deficits and altered brain structure. Recent toxicological evidence suggests that TRAP, a complex mixture of metals, elemental and organic carbon, polycyclic aromatic hydrocarbons, and fine and ultrafine particulate matter, is capable of inducing neuroinflammation and translocation across the blood-brain barrier resulting in direct exposure to the brain. The aims of this study are to determine if children exposed to increased levels of TRAP during early stages of brain development have neurobehavioral deficits in childhood and to assess the physiologic impact of TRAP exposure on brain structure, organization, and function. The Cincinnati Childhood Allergy and Air Pollution Study (CCAAPS), a prospective cohort study, provides an extraordinary opportunity to accomplish these aims. The CCAAPS cohort was recruited to examine the association between traffic exhaust and the development of allergic disease and asthma. Children enrolled in CCAAPS must have resided either less than 400 m or greater than 1500 m from a major highway at the time of their birth. TRAP exposure during early childhood has been characterized using ambient air monitoring and spatial models. Clinical health assessments, biomarkers, health questionnaires, and addresses of all home, daycare, and school locations have been collected at ages 1-4 and 7. The proposed study is innovative as it exploits all of the collected health, air monitoring, and modeling data and extends the focus of the CCAAPS cohort to examine the impact of early childhood TRAP exposure on neurobehavior and neuroimaging outcomes. A carefully selected battery of valid and reliable tests will be administered at age 11-12 to assess neurobehavioral development. Another unique aspect is the proposed nested study of children with high and low exposure to TRAP during early childhood to assess the physiologic impact of TRAP on the developing brain using quantitative magnetic resonance imaging (MRI). The anticipated results will address a significant gap in scientific knowledge of the potential neurotoxicity of a ubiquitous environmental exposure with far-reaching consequences for future studies and public health.

描述（由申请人提供）：拟议的研究将解决以下假设：在大脑发育的关键时期，与交通相关的空气污染（TRAP）暴露与神经行为的改变显着相关，包括认知，记忆，执行功能，全球智力，全球智能，神经智能，行为调节，行为调节，行为调节，脑部解剖学和物理学和物理学的缺陷。在产前和童年时期暴露于环境神经毒性与神经行为缺陷和大脑结构改变有关。最近的毒理学证据表明，陷阱是金属，元素和有机碳的复杂混合物，多环芳烃的复杂混合物，以及精细的和超细的颗粒物，能够诱导神经炎症和易位跨血脑屏障，导致直接暴露于大脑。这项研究的目的是确定是否在大脑发育的早期阶段，暴露于陷阱水平增加的儿童在儿童时期患有神经性缺陷，并评估陷阱暴露对脑结构，组织和功能的生理影响。辛辛那提儿童过敏和空气污染研究（CCAAPS）是一项前瞻性队列研究，为实现这些目标提供了非凡的机会。招募了CCAAPS队列，以检查交通排气与过敏性疾病和哮喘发展之间的关联。参加CCAAP的儿童在出生时必须居住在主要高速公路上的400 m或大于1500 m。幼儿期的陷阱暴露是使用环境空气监测和空间模型来表征的。 Clinical health assessments, biomarkers, health questionnaires, and addresses of all home, daycare, and school locations have been collected at ages 1-4 and 7. The proposed study is innovative as it exploits all of the collected health, air monitoring, and modeling data and extends the focus of the CCAAPS cohort to examine the impact of early childhood TRAP exposure on neurobehavior and neuroimaging outcomes.精心选择的有效和可靠测试的电池将在11-12岁时进行评估，以评估神经行为的发育。另一个独特的方面是对儿童早期陷阱暴露于陷阱的儿童提出的嵌套研究，以评估陷阱使用定量磁共振成像（MRI）评估陷阱对发育大脑的生理影响。预期的结果将解决有关无处不在的环境暴露的潜在神经毒性的科学知识的巨大差距，对未来的研究和公共卫生产生了深远的影响。