MACRONUTRIENT COMPOSITION OF DIET AND RISK FACTORS FOR CARDIOVASCULAR DISEASE

饮食的大量营养素组成和心血管疾病的危险因素

• 批准号: 8167894
• 负责人: Lydia Bazzano
• 金额: $ 23.84万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167894
• 关键词: Adult; Advertisements; Area; Blood Pressure; Body Composition; Body Weight; Body mass index; C-reactive protein; Carbohydrates; Cardiovascular Diseases; Community Health; Computer Retrieval of Information on Scientific Projects Database; Counseling; Diastolic blood pressure; Diet; Dietitian; Fat-Restricted Diet; Fatty acid glycerol esters; Funding; Glucose; Grant; Health Fairs; Institution; Instruction; Insulin; Intervention; Leptin; Lipids; Long-Term Effects; Macronutrients Nutrition; Mails; Measures; Obesity; Participant; Persons; Plasma; Randomized; Randomized Controlled Trials; Recruitment Activity; Research; Research Personnel; Resources; Risk Factors; Scheme; Screening procedure; Serum; Source; United States National Institutes of Health; Workplace; adiponectin; arm; design; eligible participant; follow-up; resistin; waist circumference

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Project Description: The objective of this trial is to examine the long-term effects of a diet low in carbohydrates, as compared to one low in fat, on CVD risk factors, including blood pressure (BP), body weight and composition, serum lipids, plasma glucose, insulin, adipocytokines (adiponectin, leptin, resistin), and C-reactive protein (CRP) among obese adults. This study is a randomized controlled trial with a two-arm, parallel design. Using a stratified, blocked randomization scheme, eligible participants are assigned to either a low-carbohydrate intervention diet or a low fat control diet (instructions for each group will include intensive one-on-one counseling with a dietitian every week for 4 weeks followed by 10 biweekly sessions and 6 monthly sessions). This trial has 80% statistical power to detect clinically important changes in CVD risk factors. In order to conduct the trial, we will recruit 130 study participants (n=65 in each group) with a body mass index (BMI) of 30-45 kg/m2 using mass mailings, workplace screenings, community health fairs, and media advertisements in the Greater New Orleans, LA area; randomize the eligible participants to either a low-carbohydrate intervention diet for 12 months or a low fat diet for 12 months; provide diet instructions for each participant including intensive one-on-one counseling with a dietitian for a total of 15 sessions over 12 months; measure CVD risk factors (systolic and diastolic BP, body weight, body composition, waist circumference, lipid profiles, glucose and insulin levels, and levels of CRP and adipocytokines) in all participants at baseline, 3, 6, and 12 months of follow-up; and examine the differences in these risk factors among persons assigned to the low-carbohydrate intervention compared to those assigned to the low fat intervention.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 项目描述：该试验的目的是检查低碳水化合物饮食（与低脂肪饮食相比）对 CVD 危险因素（包括血压 (BP)、体重和成分、血脂）的长期影响肥胖成人中的血浆葡萄糖、胰岛素、脂肪细胞因子（脂联素、瘦素、抵抗素）和 C 反应蛋白 (CRP)。本研究是一项采用双臂平行设计的随机对照试验。使用分层、分块随机化方案，符合条件的参与者被分配到低碳水化合物干预饮食或低脂肪控制饮食（每组的说明将包括每周与营养师进行一对一的密集咨询，持续 4 周，然后10 次双周会议和 6 次每月会议）。该试验具有 80% 的统计功效来检测 CVD 危险因素的临床重要变化。为了进行试验，我们将通过群发邮件、工作场所筛查、社区健康博览会和媒体广告招募体重指数 (BMI) 为 30-45 kg/m2 的 130 名研究参与者（每组 n=65）洛杉矶大新奥尔良地区；将符合条件的参与者随机分配为 12 个月的低碳水化合物干预饮食或 12 个月的低脂肪饮食；为每位参与者提供饮食指导，包括在 12 个月内与营养师进行总共 15 次密集的一对一咨询；在基线、随访 3、6 和 12 个月时测量所有参与者的 CVD 危险因素（收缩压和舒张压、体重、身体成分、腰围、血脂、葡萄糖和胰岛素水平以及 CRP 和脂肪细胞因子水平）向上;并检查分配给低碳水化合物干预组的人与分配给低脂肪干预组的人相比这些危险因素的差异。