SC COBRE: PROTEIN SCIENCE CORE

SC COBRE：蛋白质科学核心

• 批准号: 8168045
• 负责人: Christopher Davies
• 金额: $ 12.91万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168045
• 关键词: Behavior; Calorimetry; Centers of Research Excellence; Circular Dichroism; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Institution; Production; Proteins; Pseudomonas; Quinolones; Research; Research Personnel; Resources; Science; Signal Transduction; Source; United States National Institutes of Health; light scattering

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Protein Science Core has continued to support the activities of the COBRE investigators. Specifically, it has been used to over-produce and purify several proteins, and to characterize their biophysical behavior using circular dichroism, dynamic light scattering and isothermal calorimetry. Most notably, Dr. Yong-mei Zhang, who is a new COBRE Investigator, has begun to use the lab extensively for the production of several proteins involved in Pseudomonas quinolone signaling.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 蛋白质科学核心继续支持 COBRE 研究人员的活动。 具体来说，它已被用于过量生产和纯化多种蛋白质，并使用圆二色性、动态光散射和等温量热法来表征其生物物理行为。最值得注意的是，新任 COBRE 研究员张永梅博士已开始广泛使用该实验室来生产几种与假单胞菌喹诺酮信号传导相关的蛋白质。