2013 Apoptotic Cell Recognition & Clearance Gordon Research Conference and Gordon

2013 凋亡细胞识别

• 批准号: 8510853
• 负责人: Nathalie Claudine Franc
• 金额: $ 1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-03-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8510853
• 关键词: Address; Adult; Animal Model; Apoptosis; Apoptotic; Area; Autoimmune Diseases; Autoimmunity; Biochemistry; Biological Process; Cells; Cellular biology; Cessation of life; Chronic; Communities; Data; Defect; Development; Developmental Biology; Disease; Environment; Excision; Failure; Feedback; Fishes; Fund Raising; Funding; Future; Genetic; Health; Homeostasis; Human; Human body; Immune; Immunization; Immunology; Individual; Infection; Inflammation; Inflammatory; International; Lead; Lupus; Maintenance; Malignant Neoplasms; Minority; Molecular; Molecular Biology; Molecular Genetics; Morphogenesis; Mus; Nerve Degeneration; Neurobiology; Neurodegenerative Disorders; New England; Organ; Organism; Participant; Phagocytes; Phagocytosis; Pharmacology; Play; Postdoctoral Fellow; Process; Request for Applications; Research; Research Personnel; Research Project Grants; Resistance; Resolution; Retinal Degeneration; Scientist; Series; Time; Tissues; United States; Universities; Virus; Woman; Work; abstracting; base; career development; design; fighting; fly; graduate student; human disease; meetings; neoplastic cell; neurogenesis; novel therapeutics; pathogen; peer; posters; prevent; programs; public health relevance; symposium; tissue repair; tumor immunology; tumorigenesis

DESCRIPTION (provided by applicant): About 50-200 billion of our cells die daily by apoptosis or programmed cell death in the human body. The mechanisms of apoptosis have been extensively studied, but those of the elimination of apoptotic cells are much less understood. Apoptotic cells are rapidly engulfed and digested by their neighbors or by professional phagocytes in a process known as phagocytosis, clearance or efferocytosis. During development this process plays a key role in tissue morphogenesis and renewal. It also allows for the maintenance of tissue homeostasis in adults and promotes the resolution of inflammation. Failure to clear apoptotic cells can result in developmental defects, chronic inflammatory disorders, autoimmune and neurodegenerative diseases. For example, it has been associated with Lupus, a chronic inflammatory autoimmune disease, and with retinal degeneration. Dying cells can be cleared before completion of their programmed death, and failure in this process may result in cancer. A thorough understanding of efferocytosis is essential to design new therapies to prevent or treat chronic inflammation, autoimmune and neurodegenerative diseases, and cancer. Some of the molecular mechanisms of apoptotic cell clearance are shared with those of pathogen clearance, and thus studying efferocytosis will also lead to new therapies to fight infections. This is critical since pathogens are becoming resistant to current treatments. At this 2013 Apoptotic Cell Recognition & Clearance Gordon Research Conference and its associated Gordon Research Seminar to be held from June 22-28 at the University of New England, Biddeford, ME, we will discuss the latest advances made in our understanding of the molecular mechanisms of efferocytosis in all model organisms, from worm, fly, fish and mouse, to mammalian (including human) cells in the context of both healthy and disease states. This conference, held every other year since 2003, will be the sixth in its series and is the only regular international meeting in this field. This conference will bring together researchers with expertise in biochemistry, genetics, cell, molecular and developmental biology, neurobiology, immunology and pharmacology, as well as clinicians who are at the forefront of the field. Post-docs and graduate students will have the opportunity to orally present their work and network amongst themselves at the GRS. This GRS will prepare and encourage them to attend and participate at the GRC, where they can also present their work in poster format to discuss and exchange ideas with the leaders in the field. The best GRS speakers and some GRC poster presenters will be selected for short talks at the GRC, a much sought-after exposure and opportunity for feedback from their peers.

描述（由申请人提供）：大约500-100亿个细胞每天死于人体中的细胞凋亡或程序性细胞死亡。凋亡的机制已经进行了广泛的研究，但是消除凋亡细胞的机制知之甚少。凋亡细胞在被称为吞噬作用，清除率或for吞作用的过程中迅速被邻居或专业吞噬细胞吞没和消化。在开发过程中，这一过程在组织形态发生和更新中起关键作用。它还允许维持成人组织稳态，并促进炎症的分辨率。无法清除凋亡细胞会导致发育缺陷，慢性炎症性疾病，自身免疫性和神经退行性疾病。例如，它与狼疮，一种慢性炎症自身免疫性疾病以及视网膜变性有关。垂死的细胞可以在完成编程死亡之前清除，并且在此过程中失败可能导致癌症。对炎性细胞增多症的透彻理解对于设计新疗法以预防或治疗慢性炎症，自身免疫性和神经退行性疾病以及癌症至关重要。凋亡细胞清除的某些分子机制与病原体清除率共享，因此研究吞噬作用也将导致新的疗法与感染作用。这至关重要，因为病原体对当前治疗具有抗性。 在2013年的凋亡细胞识别和清除戈登研究会议及其相关的戈登研究研讨会上，将于6月22日至28日在我的比德福德大学新英格兰大学举行，我们将讨论所有模型机构中所有模型生物体中的effererocytosion，包括人类的人类和人类的情况，包括在所有模型生物体中，包括人类和人类的情况下，都在于对分子的摄取机制的理解，包括人类的effererianian和人类的情况。 自2003年以来每隔一年举行的一次会议将是其系列的第六次会议 这是该领域唯一的常规国际会议。这次会议将汇集具有生物化学，遗传学，细胞，分子和发育生物学，神经生物学，免疫学和药理学的研究人员，以及处于该领域最前沿的临床医生。毕业后和研究生将有机会在GRS上口头介绍他们的工作和网络。这个GRS将准备并鼓励他们参加并参加GRC，在那里他们还可以以海报格式介绍他们的作品，以与该领域的领导者讨论和交流想法。最好的GRS演讲者和一些GRC海报演示者将被选为在GRC进行简短演讲，这是一个引人注目的接触和同行反馈的机会。