EFFECT OF PRE AND POSTNATAL NUTRITIONAL PROGRAMMING ON SCD1 ACTIVITY AND OBESITY

产前和产后营养规划对 SCD1 活性和肥胖的影响

• 批准号: 8174506
• 负责人: JENNIFER K YEE
• 金额: $ 2.05万
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8174506
• 关键词: Animals; Blood; Body Composition; Characteristics; Child; Computer Retrieval of Information on Scientific Projects Database; Development; Diabetes Mellitus; Enzymes; Equilibrium; Funding; Grant; Human; Infant; Infant Overnutrition; Institution; Lead; Life; Malnutrition; Metabolic; Metabolic syndrome; Monounsaturated Fatty Acids; Newborn Infant; Nutritional; Obesity; Overnutrition; Research; Research Personnel; Resources; Role; Saturated Fatty Acids; Source; Stearoyl-CoA Desaturase; United States National Institutes of Health; Up-Regulation; in utero; indexing; nutrition; obesity prevention; postnatal; prenatal; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Prenatal and postnatal nutrition has been shown to be important in programming of body composition and metabolic characteristics in humans and animals. Stearoyl-CoA desaturase enzyme-1 (SCD1) is an enzyme that converts saturated fatty acids (18:0 and 16:0) to monounsaturated fatty acids (18:1 and 16:1, respectively) and has been implicated in development of obesity, diabetes, and metabolic syndrome. Nutritional programming effects on SCD1 activity have not yet been explored. In this study, we plan to study SCD1 activity in infants exposed to in utero overnutrition, infants exposed to in utero undernutrition, and compare them to infants exposed to in utero nutritional balance. We wish to establish the role of SCD1 activity in nutritional programming so that it can be studied as a target for prevention of obesity in early life. Our hypothesis is that in utero states of maternal overnutrition or undernutrition will lead to an increase in the ratio of monounsaturated to saturated fatty acids in the blood, called the desaturation index and that the increase in desaturation index will be predictive for development of adiposity in young children. An increase in the desaturation index would represent upregulation of the enzyme SCD1. Aim of this study: To compare the desaturation index in newborn infants exposed to in utero overnutrition and undernutrition, versus normal controls.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 产前和产后营养已被证明对于人类和动物的身体成分和代谢特征的规划非常重要。硬脂酰辅酶 A 去饱和酶 1 (SCD1) 是一种将饱和脂肪酸（18:0 和 16:0）转化为单不饱和脂肪酸（分别为 18:1 和 16:1）的酶，与肥胖的发生有关、糖尿病和代谢综合征。营养规划对 SCD1 活性的影响尚未被探索。在这项研究中，我们计划研究子宫内营养过剩的婴儿和子宫内营养不良的婴儿的SCD1活性，并将它们与子宫内营养平衡的婴儿进行比较。 我们希望确定 SCD1 活性在营养规划中的作用，以便将其作为预防生命早期肥胖的目标进行研究。 我们的假设是，在子宫内，母亲营养过剩或营养不良会导致血液中单不饱和脂肪酸与饱和脂肪酸的比率增加，称为去饱和指数，并且去饱和指数的增加将预示着年轻人肥胖的发生。孩子们。去饱和指数的增加代表酶 SCD1 的上调。 本研究的目的：比较子宫内营养过剩和营养不良的新生儿与正常对照组的去饱和指数。