HYPOPITUITARISM IN RETIRED PROFESSIONAL FOOTBALL PLAYERS

退役职业足球运动员的垂体功能低下

• 批准号: 8174513
• 负责人: CHRISTINA C. WANG
• 金额: $ 8.48万
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8174513
• 关键词: Alzheimer' s Disease; American; Area; Attention; Brain Concussion; Computer Retrieval of Information on Scientific Projects Database; Diagnosis; Disease; Functional disorder; Funding; Grant; Health; Hormonal; Hormone replacement therapy; Hypopituitarism; Individual; Institution; Investigation; Lead; Manufactured football; Mild Concussions; Nerve Degeneration; Physiological; Pituitary Gland; Quality of life; Recording of previous events; Research; Research Personnel; Resources; Risk Factors; Sex Functioning; Sexual Dysfunction; Source; Traumatic Brain Injury; United States National Institutes of Health; behavioral impairment; career; cohort; mild neurocognitive impairment; retiree

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. More than 1.2 million Americans sustain a traumatic brain injury (TBI) annually, the majority of which are mild TBIs (MTBI) or cerebral concussions. Repeat concussions have been identified as a risk factor for the occurrence (or early expression) of neurodegenerative dementing disorders, including Mild Cognitive Impairment (MCI) and Alzheimer s disease (AD). The pathophysiology of these disorders is unclear and warrants further investigation. One particular area that has received little attention is the concept that repeat MTBI can lead to pituitary dysfunction (hypopituitarism) which in turn can be a direct cause of reduced general health, poor quality of life and sexual dysfunction. This linkage between TBI, hypopituitarism, reduced health and poor quality of life is already well-established for individuals sustaining a single moderate or severe TBI; recent studies indicate that these more severe TBIs lead to hypopituitarism in up to one third of individuals. We propose to study a cohort of retired NFL players who have documented poor quality of life to determine the relationship between these complaints, their concussion (MTBI) history, their pituitary hormonal function and sexual function. We hypothesize that the number of MTBIs sustained in their NFL career will correlate with the rate of hypopituitarism and that untreated hypopituitarism in these individuals will be associated with poor quality of life and general health, neuro-behavioral impairment and sexual dysfunction. This study will also determine the possible benefits of physiological hormone replacement therapy in retirees with diagnosed hypopituitarism.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 每年有超过 120 万美国人遭受创伤性脑损伤 (TBI)，其中大多数是轻度 TBI (MTBI) 或脑震荡。重复脑震荡已被确定为神经退行性痴呆症发生（或早期表现）的危险因素，包括轻度认知障碍（MCI）和阿尔茨海默病（AD）。这些疾病的病理生理学尚不清楚，需要进一步研究。 一个很少受到关注的特殊领域是重复 MTBI 可导致垂体功能障碍（垂体功能减退症）的概念，这反过来又可能是总体健康状况下降、生活质量差和性功能障碍的直接原因。对于遭受单一中度或重度 TBI 的个体来说，TBI、垂体功能低下、健康状况下降和生活质量差之间的这种联系已经明确；最近的研究表明，这些更严重的创伤性脑损伤会导致多达三分之一的人出现垂体功能低下。我们建议对一群生活质量差的退役 NFL 球员进行研究，以确定这些抱怨、他们的脑震荡 (MTBI) 病史、他们的垂体激素功能和性功能之间的关系。我们假设，在 NFL 职业生涯中持续的 MTBI 数量将与垂体机能减退症的发生率相关，并且这些个体中未经治疗的垂体机能减退症将与生活质量和总体健康状况不佳、神经行为损伤和性功能障碍相关。这项研究还将确定生理激素替代疗法对诊断为垂体功能减退症的退休人员的可能益处。