EARLY IDENTIFICATION OF SUBCLINICAL ATHEROSCLEROSIS USING NONINVASIVE IMAGING

使用无创成像早期识别亚临床动脉粥样硬化

• 批准号: 8174458
• 负责人: Daniel S Berman
• 金额: $ 14.84万
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8174458
• 关键词: Atherosclerosis; Biochemical Markers; Calcium; Cardiac; Clinic Visits; Clinical; Computer Retrieval of Information on Scientific Projects Database; Coronary; Coronary Arteriosclerosis; Counseling; Diagnosis; Early Diagnosis; Early identification; Employee; Family; Foundations; Friends; Funding; Grant; Heart Research; Image; Institution; Mails; Medical center; Modification; Monitor; Outcome; Participant; Population Study; Predictive Value; Procedures; Program Research Project Grants; Questionnaires; Randomized; Research; Research Personnel; Resources; Risk Assessment; Risk Estimate; Risk Factors; Scanning; Source; United States National Institutes of Health; Visit; X-Ray Computed Tomography; aged; base; coronary artery calcification; programs; volunteer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Early Identification of subclinical Atherosclerosis using noninvasive Imaging Research (EISNER) is a multi-project research program funded by The Eisner Foundation. The primary objective of the research program is to investigate the predictive value of coronary calcium by cardiac CT in combination with clinical, standard and new biochemical markers for clinical outcomes in the early detection and management of coronary artery disease (CAD). This project includes five studies. In EISNER Heart Study 1, the study population will be comprised of 2,250 asymptomatic employees and volunteers of Cedars-Sinai Medical Center and their family and friends, aged 35-80, inclusive, who have never been diagnosed with coronary artery disease. Study procedures include a baseline clinic visit during which participants will undergo cardiac risk assessments to determine their estimated risk for developing CAD. Participants will then be randomized to either have a cardiac CT scan for coronary calcification or not in a 2:1 ratio. At the end of baseline, participants will receive counseling on risk factor modification based on the risk assessment and the results of the cardiac CT scan, if they undergo the scan. Questionnaire will be administered annually by mail to monitor clinical outcomes and risk factor modification. At Year 4, all participants will return for a clinic visit to repeat the cardiac risk assessment procedures and receive a cardiac CT scan. All participants will receive a cardiac CT scan at the Year 4 visit.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 使用无创成像研究早期识别亚临床动脉粥样硬化 (EISNER) 是一个由艾斯纳基金会资助的多项目研究计划。该研究项目的主要目标是研究心脏 CT 结合临床、标准和新生化标志物对冠状动脉钙的预测价值，以预测冠状动脉疾病 (CAD) 早期检测和治疗的临床结果。该项目包括五项研究。 在 EISNER 心脏研究 1 中，研究人群将由 Cedars-Sinai 医疗中心的 2,250 名无症状员工和志愿者及其家人和朋友组成，年龄在 35 岁至 80 岁之间，从未被诊断出患有冠状动脉疾病。研究程序包括基线临床访问，在此期间参与者将接受心脏风险评估，以确定他们患 CAD 的估计风险。然后，参与者将以 2:1 的比例随机分配接受心脏 CT 扫描以检查冠状动脉钙化或不接受心脏 CT 扫描。在基线结束时，参与者将根据风险评估和心脏 CT 扫描结果（如果接受扫描）接受有关危险因素修改的咨询。调查问卷将每年通过邮寄方式进行，以监测临床结果和危险因素的改变。在第 4 年，所有参与者都将返回诊所，重复心脏风险评估程序并接受心脏 CT 扫描。所有参与者将在第 4 年访视时接受心脏 CT 扫描。