Comprehensive NeuroAIDS Core Center

综合神经艾滋病核心中心

• 批准号: 8210493
• 负责人: Kamel Khalili
• 金额: $ 164.42万
• 依托单位: TEMPLE UNIV OF THE COMMONWEALTH
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-05 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8210493
• 关键词: Comprehensive; NeuroAIDS; Core; Center

This revised application seeks support to establish a Comprehensive NeuroAIDS Core Center (CNACC) at the Temple University School of Medicine in order to bring highly needed infrastructure for basic scientists and clinicians involved in HIV-1/AIDS research and neurological, neurodegenerative, and neurobehavioral disorders. The central theme of CNACC is structured based on our hypothesis that understanding the mechanisms of HIV-1/CNS interactions at the molecular, cellular, and experimental animal model levels and bidirectional communication of laboratory findings and clinical observations to validate basic science discoveries are prerequisites for the development of effective, safe, and reliable approaches for early diagnostics and therapeutics for AIDS-associated neurological dysfunctions. The CNACC will provide unprecedented infrastructure to a large group of neuroAIDS investigators who plan to pursue their objectives using multidisciplinary approaches in cell culture, small animal models, and in the clinical setting for assessing gene expression and biomarker identification at the cellular and molecular levels. Further, through the Developmental Core, the CNACC will provide a unique opportunity for training and mentoring of junior and clinical investigators and attract and develop physician scientists in the field of neuroAIDS. Through CNACC, we will provide start-up funds for new and innovative pilot projects of newly recruited, independent investigators and will support feasibility studies for more established neuroAIDS investigators. The funding through this center will create a unique infrastructure that will serve to enhance and extend the effectiveness of ongoing HIV-1 investigations and promote translational research in neuroAIDS at Temple and other medical institutions in the greater Philadelphia area that are involved in basic science and clinical AIDS research. With its comprehensive structural organization encompassing broadly based cores ranging from molecular biology to experimental animals to the clinical arena directed by skilled and highly competent investigators from various disciplines, CNACC will support research in a variety of areas such as virology, basic and behavioral neuroscience, and clinical science, all of which are aimed toward the discovery of better diagnostics and effective therapeutic agents toward AIDS/CNS disorders.

此修订后的申请寻求支持在天普大学医学院建立综合神经艾滋病核心中心 (CNACC)，以便为参与 HIV-1/艾滋病研究以及神经系统、神经退行性和神经行为障碍的基础科学家和临床医生提供急需的基础设施。 CNACC 的中心主题是基于我们的假设构建的，即了解 HIV-1/CNS 在分子、细胞和实验动物模型水平上相互作用的机制以及实验室研究结果和临床观察的双向交流以验证基础科学发现是实现这一目标的先决条件。开发有效、安全和可靠的方法来早期诊断和治疗艾滋病相关的神经功能障碍。 CNACC 将为一大批神经艾滋病研究人员提供前所未有的基础设施，他们计划在细胞培养、小动物模型以及临床环境中使用多学科方法来实现其目标，以在细胞和分子水平上评估基因表达和生物标志物识别。此外，通过发展核心，CNACC 将为初级和临床研究人员的培训和指导提供独特的机会，并吸引和培养神经艾滋病领域的医师科学家。通过 CNACC，我们将为新招募的独立研究人员的新的创新试点项目提供启动资金，并将支持更多成熟的神经艾滋病研究人员的可行性研究。该中心的资金将创建一个独特的基础设施，用于增强和扩大正在进行的 HIV-1 研究的有效性，并促进坦普尔和大费城地区其他涉及基础科学和临床的医疗机构的神经艾滋病转化研究艾滋病研究。 CNACC 的综合结构组织涵盖从分子生物学到实验动物再到临床领域的广泛核心，由来自不同学科的熟练且高素质的研究人员指导，CNACC 将支持病毒学、基础和行为神经科学等各个领域的研究。临床科学，所有这些都旨在发现针对艾滋病/中枢神经系统疾病的更好的诊断方法和有效的治疗药物。