Regulation of the Reproductive Tract Environment and Prevention of HIV Infection

生殖道环境的调节与HIV感染的预防

• 批准号: 8541405
• 负责人: Charles Robert Wira
• 金额: $ 0.5万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-15 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8541405
• 关键词: American; Boston; Chemicals; Coitus; Collaborations; Combined Oral Contraceptives; Contraceptive Agents; Contraceptive methods; Educational workshop; Environment; Fostering; Genital system; Goals; Gonadal Steroid Hormones; HIV; HIV Infections; HIV-1; Hormonal; Hormones; Immune; Immunologist; Implant; International; Journals; Lead; Mucous Membrane; Postdoctoral Fellow; Predisposition; Prevention; Prevention strategy; Publications; Regulation; Reproductive Immunology; Research; Research Personnel; Role; Scientist; Seminal fluid; Sexual Transmission; Societies; Tissues; Training; Trauma; Vaccines; Vaginal Ring; Woman; base; design; graduate student; hormonal contraception; hormone regulation; meetings; men; microbicide; microbiome; prevent; public health relevance; reproductive; subcutaneous; symposium; transmission process

DESCRIPTION (provided by applicant): Support for the HIV Symposium entitled "Hormone Regulation of the Mucosal Environment in the Reproductive Tract and the Prevention of HIV Infection" is requested. This Symposium will take place as a part of ISIR2013 which is the 12th Meeting of the International Society for Immunology of Reproduction (ISIR) conjoined with the 33rd annual Meeting of American Society for Reproductive Immunology (ASRI) on May 28 - June 1, 2013 in Boston, MA. Hosted by ASRI, this conference brings together the world's best scientists and clinicians in reproductive immunology. Our proposed HIV Symposium will bring leaders in HIV research and reproductive immunology into contact to exchange information, identify gaps, and explore avenues of collaboration. Based on the current controversy with regard to the role of contraception in HIV acquisition and transmission, the overall objective of our workshop is to emphasize the importance of exogenous and endogenous hormones and the mucosal environment of the reproductive tract in HIV transmission. Specific Aims are designed to: 1) Discuss the role of sex hormones (endogenous and exogenous) in enhancing and/or suppressing mucosal immune protection against HIV transmission. 2) Define the role of the mucosal environment (secreted and tissue) in the reproductive tract in preventing or enhancing HIV acquisition/transmission of HIV infection. 3) Identify those factors (microbiome, STIs, semen, trauma) that are hormonally modulated in the FRT and may influence susceptibility to HIV infection. 4) Encourage collaborative activity between HIV researchers and reproductive immunologists with special emphasis on new investigators, trainees and under-represented groups. This HIV Symposium will have a special focus in that it will provide a unique opportunity for graduate students, postdoctoral fellows and under-represented groups to meet and interact with leaders in the field of HIV transmission and reproductive immunology. This application supports a long-term goal of the ISIR and ASRI, which is to foster training of junior investigators An additional goal of this conference is to have each of the invited speakers submit a review/article on the subject of their conference presentation for publication in a Special Issue o the American Journal of Reproductive Immunology. Our proposed Symposium will lead to enhanced microbicide, PrEP and vaccine prevention strategies by understanding the interactions between the genital mucosa and HIV to better promote inhibition of HIV transmission and acquisition.

描述（由申请人提供）：请求支持题为“生殖道粘膜环境的激素调节和预防艾滋病毒感染”的艾滋病毒研讨会。本次研讨会将作为 ISIR2013 的一部分举行，ISIR2013 是国际生殖免疫学会 (ISIR) 第 12 届会议，与美国生殖免疫学会 (ASRI) 第 33 届年会于 2013 年 5 月 28 日至 6 月 1 日在美国举行。马萨诸塞州波士顿本次会议由 ASRI 主办，汇聚了世界上生殖免疫学领域最优秀的科学家和临床医生。我们提议的艾滋病毒研讨会将使艾滋病毒研究和生殖免疫学领域的领导者进行接触，以交流信息、找出差距并探索合作途径。基于目前关于避孕在艾滋病毒感染和传播中的作用的争议，我们研讨会的总体目标是强调外源性和内源性激素以及生殖道粘膜环境在艾滋病毒传播中的重要性。具体目标旨在： 1) 讨论性激素（内源性和外源性）在增强和/或抑制针对 HIV 传播的粘膜免疫保护中的作用。 2) 定义生殖道粘膜环境（分泌和组织）在预防或增强 HIV 获得/传播 HIV 感染中的作用。 3) 确定 FRT 中受激素调节并可能影响 HIV 感染易感性的因素（微生物组、性传播感染、精液、创伤）。 4) 鼓励艾滋病毒研究人员和生殖免疫学家之间的合作活动，特别注重新研究人员、受训人员和代表性不足的群体。本次艾滋病毒研讨会的一个特别重点是，它将为研究生、博士后研究员和代表性不足的群体提供一个独特的机会，与艾滋病毒传播和生殖免疫学领域的领导者会面和互动。此应用程序支持 ISIR 和 ASRI 的长期目标，即促进初级研究人员的培训 本次会议的另一个目标是让每位受邀演讲者提交关于其会议演示主题的评论/文章以供出版在《美国生殖免疫学杂志》的特刊中。我们提议的研讨会将通过了解生殖器粘膜和艾滋病毒之间的相互作用来加强杀菌剂、PrEP 和疫苗预防策略，以更好地促进抑制艾滋病毒的传播和获得。