A Preconception Cohort Study on Oil and Gas Development, Fertility, and Pregnancy

关于石油和天然气开发、生育力和怀孕的孕前队列研究

• 批准号: 10480218
• 负责人: Mary D Willis
• 金额: $ 41.25万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-15 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10480218
• 关键词: Address; Affect; Air; American; Aromatic Polycyclic Hydrocarbons; Award; Back; Benzene; Birth; Boston; Canada; Chemicals; Child; Child Development; Child Health; Cohort Studies; Communities; Complex; Conceptions; Contracts; Couples; Data; Data Analyses; Data Collection; Data Science; Development; Diet; Disease; Enrollment; Environmental Epidemiology; Environmental Hazards; Environmental Pollution; Epidemiology; Exposure to; Faculty; Fellowship; Female; Fertility; Flare; Formaldehyde; Funding; Gases; Geography; Gestational Diabetes; Grant; HRK gene; Health; Human; Hypertension; Industry; Institutes; Interdisciplinary Study; Internet; Late pregnancy; Life Style; Light; Live Birth; Logistics; Low Birth Weight Infant; Measurement; Measures; Medical History; Menstrual cycle; Mentors; Metabolic Diseases; Methods; National Institute of Child Health and Human Development; National Institute of Environmental Health Sciences; Noise; Oils; Outcome; Participant; Particulate Matter; Pharmaceutical Preparations; Play; Policies; Pollution; Positioning Attribute; Postpartum Women; Pre-Eclampsia; Pregnancy; Pregnancy loss; Premature Birth; Probability; Production; Prospective cohort; Prospective cohort study; Province; Public Health; Public Health Schools; Questionnaires; Recording of previous events; Reporting; Reproductive Health; Research; Research Design; Research Personnel; Resources; Risk; Role; Spontaneous abortion; Surveys; TNFSF15 gene; Techniques; Time; Toluene; Toxicology; Training; United States; United States National Institutes of Health; Universities; Water; Woman; Work; Workplace; base; career; cohort; community intervention; cost effective; data integration; design; early pregnancy; early pregnancy loss; epidemiology study; follow-up; improved; novel; pollutant; population health; postpartum health; pre-doctoral; pregnancy hypertension; professor; prospective; recruit; reproductive; risk perception; social stressor; sociodemographics; time-to-pregnancy; toxicant; trying to conceive; volatile organic compound

PROJECT SUMMARY Over 17.6 million North Americans live within 1.6km of an oil and gas development (OGD) facility. Recent studies indicate that OGD results in the release of reproductive toxicants (e.g., particulate matter, volatile organic compounds [VOCs], polycyclic aromatic hydrocarbons [PAHs]) at levels that may harm human health, including fertility, early pregnancy loss, pregnancy-related disorders, and birth outcomes. Epidemiologic studies on OGD to date have largely focused on live birth outcomes, have not included personal exposure measurements, and have little data on key confounders. Building upon data analysis from an NIEHS-funded predoctoral fellowship (F31-ES029801) and training in prospective cohort designs in her postdoctoral research, Dr. Mary Willis’ Early Independence Award application launches the first prospective cohort study on OGD-related pollution and reproductive health. This proposal leverages ongoing recruitment from the Pregnancy Study Online (PRESTO, R01-HD086742), an internet-based preconception cohort study of North American couples trying to conceive (n>16,000 female participants), to examine the influence of OGD-related exposures on reproductive health. This cohort has remarkable geographic diversity, spanning all 50 U.S. states and all 10 Canadian provinces. To date, >4,500 of the women reside in communities with OGD activity and this application will use geo-targeted methods to enroll an additional 1,000 women. Aim 1 develops OGD-related exposure metrics in the PRESTO cohort, an extension of Dr. Willis’ previous work. Exposure assessment methods include 1a) complex spatial data integration of industry-related information that spans back to participants’ own births, 1b) a supplemental questionnaire of perceived risks about OGD, and 1c) personal exposures to air, water, and noise in a subset of 150 women at three time points in the preconception to early pregnancy periods. All exposure assessment methods are validated, state-of-the-art approaches. Aim 2 applies these exposure metrics in a longitudinal framework to examine the influence of OGD on important reproductive health outcomes in the full PRESTO cohort. Outcomes include 2a) fertility (fecundability, the per-cycle probability of pregnancy), 2b) pregnancy loss (spontaneous abortion), 2c) pregnancy-related hypertensive and metabolic disorders (gestational hypertension, pre-eclampsia, gestational diabetes), and 2d) birth outcomes (preterm birth, low birth weight.) The aims set the stage for a “Research to Action” proposal that explores the efficacy of personal or community interventions for specific OGD exposures, as well as the groundwork for an R01 proposal with follow-up for maternal postpartum health and child development. By leveraging an established internet-based prospective cohort study, this proposal addresses the logistical challenges of efficiently assessing the influence of health effects of emerging environmental hazards. The results of this project have high potential to improve public health by demonstrating a novel policy-relevant framework to investigate emerging environmental hazards. This award will allow Dr. Willis to launch her career at the intersection of environmental epidemiology, data science, and reproductive health.

项目摘要 超过1760万北美人的生活在石油和天然气开发（OGD）设施的1.6公里以内。最近的研究 表明OGD导致释放生殖有毒物质（例如颗粒物，挥发性有机物 化合物[VOC]，多环芳烃[PAHS]）的水平可能损害人类健康，包括 生育能力，早期妊娠丧失，与妊娠有关的疾病和出生结果。 OGD的流行病学研究 迄今 关于关键混杂因素的数据很少。基于NIEHS资助的奖学金奖学金的数据分析 （F31-ES029801）以及她的博士后研究中的潜在队列设计培训，玛丽·威利斯博士的早期 独立奖申请启动了第一项有关OGD相关污染和的前瞻性队列研究 生殖健康。该提案利用在线妊娠研究的持续招聘（Presto， R01-HD086742），基于互联网的北美夫妇试图概念化的夫妻的同伴研究 （n> 16,000名女性参与者），研究与OGD相关的暴露对复制健康的影响。这 队列具有显着的地理多样性，涵盖了美国所有50个州和所有10个加拿大计划。迄今为止， > 4,500名妇女居住在OGD活动的社区中，此应用将使用靶向地理的方法 再招募1,000名女性。 AIM 1在Presto队列中开发与OGD相关的暴露指标 威利斯博士以前的工作的扩展。暴露评估方法包括1A）复杂的空间数据 跨越参与者自己的出生的行业相关信息的整合，1B）补充 有关OGD的感知风险和1C的调查表 在怀孕早期的三个时刻，有150名妇女在三个时间点。所有暴露评估 方法已验证，最先进的方法。 AIM 2在纵向中应用这些暴露指标 框架检查OGD对完整Presto中重要复制健康结果的影响 队列。结果包括2A）生育能力（可承受性，每周一次的怀孕概率），2B）怀孕丧失 （自发流产），2C）与怀孕相关的高血压和代谢性疾病（妊娠高血压， 前宾夕法尼亚，妊娠糖尿病）和2d）出生结果（早产，低出生体重。）目标设定 阶段进行“行动研究”提案，探讨个人或社区干预效率的效率 特定的OGD暴露，以及R01提案的基础，并随访产后 健康和儿童发展。通过利用一项基于Internet的前瞻性队列研究，这是 提案解决了有效评估新兴健康影响影响的后勤挑战 环境危害。该项目的结果具有很高的潜力，可以通过证明 一个与政策相关的新型框架，以调查新兴的环境危害。该奖项将允许威利斯博士 在环境流行病学，数据科学和再现健康的交叉点开始她的职业生涯。