Changes in Sleep and Cognition in Older Women

老年女性睡眠和认知的变化

• 批准号: 8550740
• 负责人: Katie L Stone
• 金额: $ 59.45万
• 依托单位: CALIFORNIA PACIFIC MED CTR RES INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-15 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8550740
• 关键词: Activities of Daily Living; Address; Advanced Glycosylation End Products; Aging; Biological Markers; Biology; Blood; Brain; Characteristics; Circadian Rhythms; Cognition; Cognitive; Communities; Data; Data Collection; Dementia; Development; Elderly; Electroencephalography; Frequencies; Fructosamine; Functional disorder; Genes; Genetic; Genetic Polymorphism; Health; Heart; Home environment; Hypoxia; Impaired cognition; Incidence; Inflammation; Inflammatory; Insulin Resistance; Leptin; Link; Measurement; Measures; Mediating; Mediator of activation protein; Metabolic; Metabolic Marker; Metabolism; Modeling; Neurons; Nursing Homes; Outcome; Pathway interactions; Performance; Physical Function; Physiological; Polysomnography; Prevention; Quality of life; Reproducibility; Rest; Risk; Role; Serum Markers; Signal Transduction; Sleep; Sleep Apnea Syndromes; Sleep Architecture; Sleep Disorders; Sleep Stages; Sleep disturbances; Specificity; Specimen; Staging; Synapses; Testing; Visual; Woman; Wrist; actigraphy; adiponectin; age related; base; cognitive function; cohort; cost effective; executive function; fall risk; falls; follow-up; functional decline; functional outcomes; genetic risk factor; genome-wide; instrumental activity of daily living; mild cognitive impairment; neuronal circuitry; neuropsychological; novel; older women; pentosidine; pressure; prevent; protective effect; sleep onset; transcription factor

DESCRIPTION (provided by applicant): In the first 5 years of the SOF Sleep and Cognition Study, we utilized objectively measured characteristics of sleep, including wrist actigraphy (n=3,161) and overnight in-home polysomnography (n=461) obtained in primarily community-dwelling older women. Among these women, a subset completed an expanded battery of cognitive function tests five years later and were classified as normal, mild cognitive impairment, or dementia. We demonstrated that several characteristics of sleep (including sleep disordered breathing, sleep quality, and circadian rest-activity rhythms) are associated with risk of incident mild cognitive impairment or dementia, and decline in cognitive function. These novel findings have important implications for the possible prevention and treatment of cognitive impairment. We now propose a cost-effective approach of extending the value of the initial collection of data and specimens supported by the SOF Sleep and Cognition Study to systematically address novel hypotheses focused on the mechanisms linking poor sleep and cognition. In addition, we will extend our follow-up of the initial cohort to identify the independent associations between sleep characteristics and cognitive function with other important age-related outcomes. Thus, the aims of our proposed renewal include: 1) To identify candidate -regions, -genes, and -pathways for both sleep characteristics and cognitive outcomes using recently obtained phenotypic and genome-wide genetic data from the SOF cohort; 2) To test the hypothesis that poor sleep is associated with both cross-sectional and longitudinal changes in metabolic dysfunction among older women, and that metabolic dysfunction mediates associations between poor sleep and cognitive outcomes; 3) To perform spectral analysis of the polysomnography EEG signal to explore associations between novel sleep exposures (including amounts of delta sleep, dissipation rates of slow wave activity, and spindle-frequency activity) with cross-sectional and longitudinal changes in metabolic dysfunction and inflammation, and with onset of cognitive impairment during 5 years of follow-up; and 4) To determine the independent associations of sleep characteristics and cognitive impairment with incident age-related outcomes including functional decline, nursing home placement, and risk of falls. The new information resulting from this renewal application has the potential to inform the development of new treatments to prevent decline in cognitive function in older adults. In addition, we will take advantage of ongoing follow-up for key age-related outcomes in the SOF study to determine whether sleep and cognition are independently related to risk for these conditions. Ultimately, our results may highlight the importance of maintaining healthy sleep characteristics in older adults to prevent the decline in cognitive and physical function associated with aging.

描述（由申请人提供）：在SOF睡眠和认知研究的前5年中，我们利用了客观测量的睡眠特征，包括腕部表观术（n = 3,161）和隔夜的家庭多聚会学（N = 461），在主要居住社区的老年妇女中获得了。在这些女性中，一个子集在五年后完成了扩大的认知功能测试，并被归类为正常的轻度认知障碍， 或痴呆。我们证明了睡眠的几种特征（包括睡眠不足的呼吸，睡眠质量和昼夜节律节奏）与发生事件的风险有关 轻度认知障碍或痴呆症，认知功能的下降。这些新颖的发现对可能的预防和治疗认知障碍具有重要意义。现在，我们提出了一种具有成本效益的方法，以扩大SOF睡眠和认知研究支持的最初收集数据和标本的价值，以系统地解决针对与睡眠不良和认知联系的机制的新颖假设。此外，我们将扩展对初始队列的随访，以确定睡眠特征和认知功能与其他重要年龄相关结果之间的独立关联。因此，我们提出的续签的目的包括：1）使用最近获得的表型和全基因组的遗传数据来识别睡眠特征和认知结果的候选 - 区域， - 遗传和 - 同步。 2）检验假说，即睡眠不良与老年妇女代谢功能障碍的横截面和纵向变化有关，而代谢功能障碍介导了睡眠不良和认知结果之间的关联； 3）进行多个脑电图脑电图信号的光谱分析，以探索新型睡眠暴露之间的关联（包括三角洲睡眠量，慢波活动的耗散率以及跨频率活动）与横截面和纵向变化的代谢功能障碍和炎症的纵向变化，以及在5年期间认知障碍的启发下的相关性； 4）确定睡眠特征和认知障碍与与年龄相关的结果的独立关联，包括功能下降，疗养院的放置和跌倒风险。该更新应用产生的新信息有可能告知新疗法的发展，以防止老年人认知功能下降。此外，我们将利用SOF研究中与年龄相关的关键结果的持续随访，以确定睡眠和认知是否与这些疾病风险独立相关。最终，我们的结果可能会强调保持老年人健康睡眠特征的重要性，以防止与衰老相关的认知和身体机能下降。