Changes in Sleep and Cognition in Older Women

老年女性睡眠和认知的变化

• 批准号: 7097540
• 负责人: Katie L Stone
• 金额: $ 109.11万
• 依托单位: CALIFORNIA PACIFIC MED CTR RES INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-15 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7097540
• 关键词: C reactive protein; actigraphy; aging; biomarker; blood chemistry; blood tests; clinical research; cognition; dementia; disease /disorder proneness /risk; female; glucose metabolism; human mortality; human old age (65+); human subject; human tissue; hypoxia; inflammation; interleukin 6; longitudinal human study; myeloperoxidase; oxidative stress; oximetry; polysomnography; sleep apnea; sleep deprivation; sleep disorders; women' s health

DESCRIPTION (provided by applicant): Disturbed sleep is commonly observed in patients with poor cognition. Based on existing cross sectional studies, it is unclear whether impaired cognitive function leads to sleep disturbance, or vice versa. Furthermore, most studies have relied on subjective assessment of sleep, which is particularly inaccurate in elderly subjects. We and others have also found that poor sleep quality is associated with increased risk of mortality. However, existing studies are unable to test whether this association is due to poor sleep efficiency independent of intermittent hypoxia. The underlying mechanisms remain unclear. During an eighth examination in the multi-center Study of Osteoporotic Fractures (SOF), we used wrist actigraphy to objectively measure sleep in > 3000 older women (mean age 84). SOF, a multi-center observational study supported by NIAMS/NIA, was designed to determine risk factors for osteoporotic fractures in > 10,000 older women. Since baseline (1986-88), clinic visits were repeated about every 2 years. All participants are contacted tri-annually to assess incident falls, fractures and deaths. We propose to repeat actigraphy, and perform overnight oximetry and an extended battery of cognitive function tests in 700 older women at two clinic sites during Exam 9. These additional measures in this unique, well-characterized cohort of older women will enable us to address the following specific aims: 1) to explore the longitudinal associations between sleep and cognitive function; 2) to determine the independent relationships of actigraphic sleep quality and intermittent hypoxia (using oximetry) with specific domains of cognitive function; 3) to test the independent associations of actigraphic sleep quality and intermittent hypoxia on risk of subsequent mortality; 4) To determine whether biochemical markers of inflammation (serum IL-6 and CRP), measures of glycemic control (fructosamine), or oxidative burden (myeloperoxidase) mediate the relationships between sleep, cognition and death.

描述（由申请人提供）：认知差的患者通常观察到睡眠不足。基于现有的横截面研究，尚不清楚认知功能受损是否导致睡眠障碍，反之亦然。此外，大多数研究都依赖于对睡眠的主观评估，这在老年受试者中尤其不准确。我们和其他人还发现，睡眠质量较差与死亡率的增加有关。但是，现有的研究无法测试这种关联是否是由于睡眠效率较差而与间歇性缺氧无关。基本机制尚不清楚。在骨质疏松骨折（SOF）的多中心研究中的第八次检查中，我们使用腕部行动术在> 3000名老年女性中客观地测量睡眠（平均年龄84岁）。 SOF是一项由Niams/NIA支持的多中心观察性研究，旨在确定> 10,000名老年妇女的骨质疏松性骨折的危险因素。自基线（1986-88）以来，大约每2年重复一次诊所就诊。与所有参与者进行三年级的联系，以评估事件跌倒，骨折和死亡。我们建议在考试9期间在两个诊所的700名妇女中进行过夜的血氧仪，并进行过夜的血氧仪和扩大的认知功能测试。这些额外的措施是这种独特的，良好的老年妇女的群体，使我们能够解决以下特定目标：1）探索睡眠和认知功能之间的长期相关性； 2）确定行为睡眠质量和间歇性缺氧（使用血氧仪）与认知功能的特定领域的独立关系； 3）测试行为睡眠质量和间歇性缺氧的独立关联，以随后的死亡风险； 4）确定炎症（血清IL-6和CRP）的生化标志物，血糖控制（果糖胺）的量度或氧化负担（骨髓过氧化物酶）是否介导睡眠，认知和死亡之间的关系。