MR Image Guided Gynecologic Brachytherapy

MR 图像引导妇科近距离放射治疗

基本信息

批准号：
8443663
负责人：
Akila Viswanathan
金额：
$ 20万
依托单位：
DANA-FARBER CANCER INST
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-06 至 2015-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8443663
关键词：
Affect Aftercare Antibodies Area Biological Markers Biopsy Bladder Brachytherapy Cancer Center Cells Cervix Neoplasms Cervix Uteri Characteristics Clinical Clinical Trials Development Diagnostic radiologic examination Diffusion Dimensions Dose Dose-Limiting Endometrial Carcinoma External Beam Radiation Therapy Future Goals Gynecologic Brachytherapy Hospitals Human Papillomavirus Image Imagery In complete remission Institutional Review Boards International Ki-67 Antigen Location Magnetic Resonance Imaging Malignant Female Reproductive System Neoplasm Malignant Neoplasms Malignant Vaginal Neoplasm Malignant neoplasm of cervix uteri Malignant neoplasm of vulva Morbidity - disease rate Needle biopsy procedure Neoplasms Normal tissue morphology Organ Outcome Pathologic Patients Pelvis Phase Physicians Positron-Emission Tomography Procedures Proliferating Proliferation Marker Proteins Protocols documentation Radiation Radioactive Recommendation Rectum Residual Cancers Residual Tumors Rest Risk Role Sampling Seeds Sigmoid colon Small Intestines Source Stratification Structure Survival Rate Time Toxic effect Tumor Markers United States National Institutes of Health Visual Weight Woman Work X-Ray Computed Tomography base design disorder risk dosimetry follow-up gastrointestinal high risk imaging modality improved interest multimodality neoplastic cell outcome forecast prospective public health relevance rectal response standard of care treatment planning trial comparing tumor tumor eradication

项目摘要

DESCRIPTION (provided by applicant): Patients with gynecologic cancers localized to the pelvis may be curatively treated with radiation. The use of brachytherapy, the placement of radioactive seeds directly into the center of the tumor, after external beam radiation, permits dose escalation to the tumor, resulting in successful regression and eradication of the tumor. However, adjacent to the tumor, critical normal tissue structures including the small bowel, sigmoid, rectum, and bladder may rest in regions that can receive high doses of radiation. In most centers in the U.S., simple imaging (X-ray or CT) with doses prescribed to a single point are the standard of care. Normal tissues are not defined by their actual dimensions, rather by points that approximate their location. In order to successfully determine the location of the tumor and its relationship to the normal tissues structures in order to minimize the dose to them, it is necessary to image the pelvis during brachytherapy applicator placement. MRI delineate tumor and OAR in the pelvis with much more precision than other imaging modalities. In this clinical trial, the utility of 3T T2- weighted MRI imaging, in addition to DWI MRI, and how the images correlate with biopsy-confirmed presence of cancer will be studied.

描述（由申请人提供）：可以用辐射对植物学癌症的患者进行治疗。近距离放射治疗的使用，将放射性种子直接放入肿瘤中心，在外部束辐射后，允许剂量升级为肿瘤，从而成功地退化和消除了肿瘤。然而，与肿瘤相邻，包括小肠，乙状结肠，直肠和膀胱在内的关键正常组织结构可能搁在可以接受高剂量辐射的区域中。在美国的大多数中心中，以单点处方为单一的剂量的简单成像（X射线或CT）是护理标准。正常组织不是由它们的实际维度来定义的，而不是通过近似其位置的点来定义的。为了成功地确定肿瘤的位置及其与正常组织结构的关系，以最大程度地减少肿瘤的剂量，必须在锻造术中对骨盆进行成像。 MRI比其他成像方式更精确地描绘了骨盆中的肿瘤和桨。在这项临床试验中，除DWI MRI外，3T T2加权MRI成像的实用性以及图像与活检确认的癌症的存在如何相关。