Virulence of MDR-TB strains

耐多药结核菌株的毒力

• 批准号: 8416930
• 负责人: IAN M ORME
• 金额: $ 22.28万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-02-15 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8416930
• 关键词: Address; Aerosols; Animal Model; Area; Bacillus (bacterium); Biological; Biology; California; Cavia; Cells; Clinical; Communities; Data; Disease Outbreaks; Disease Progression; Dose; Elements; Epidemic; Epidemiologic Studies; Exhibits; Family; Genomics; Gold; Histopathology; Human; Immune; Immune response; Infection; Laboratories; Letters; Lung; Measures; Modeling; Monitor; Multiple drug resistant Mycobacteria Tuberculosis; Mycobacterium tuberculosis; National Institute of Allergy and Infectious Disease; Organism; Pathogenesis; Pathogenicity; Pathology; Protocols documentation; Publishing; Recommendation; Regulatory T-Lymphocyte; Research; Research Priority; San Francisco; Series; Source; Testing; Time; Tuberculosis; Tuberculosis Vaccines; United States National Institutes of Health; Universities; Vaccination; Virulence; Virulent; Work; acquired immunity; base; falls; mouse model; protective effect; research study; transmission process; vaccine candidate

DESCRIPTION (provided by applicant): This proposal addresses an important element of the current tuberculosis global epidemic, namely the fact, recently stated in a document released by the NIAID, that we know next to nothing about the newly emerging clinical isolates of M. tuberculosis, many of which are W-Beijing strains. We will test the simple hypothesis here that such strains associated with high rates of transmission are simply more virulent than low transmission strains, with a secondary hypothesis being that the more virulent strains escape acquired immunity by generating regulatory T cells. These simple studies will provide important basic information about the relationship between transmissibility and virulence, and are doable within the context of an R21 application.

描述（由申请人提供）：该提案涉及当前结核病全球流行的一个重要因素，即 NIAID 最近发布的一份文件中指出的事实，即我们对新出现的结核分枝杆菌临床分离株几乎一无所知，其中许多是W-北京毒株。我们将在这里测试一个简单的假设，即与高传播率相关的菌株比低传播率菌株的毒性更强，第二个假设是毒性更强的菌株通过产生调节性 T 细胞来逃避获得性免疫。这些简单的研究将提供有关传播性和毒力之间关系的重要基本信息，并且在 R21 应用的背景下是可行的。