Functional Organization of Visual Object Processing

视觉对象处理的功能组织

基本信息

批准号：
8088104
负责人：
ROGER B TOOTELL
金额：
$ 50.84万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-06-01 至 2013-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8088104
关键词：
Agnosia Amygdaloid structure Anatomy Animals Anterior Architecture Autistic Disorder Behavioral Blindness Body part Brain Categories Clinical Discrimination Eye Face Face Processing Functional Magnetic Resonance Imaging Housing Human Ibotenic Acid Individual Injection of therapeutic agent Laboratories Lesion Macaca Magnetic Resonance Imaging Maps Measurement Measures Modeling Monkeys Neurobiology Neurons Patients Perception Photic Stimulation Postoperative Period Primates Process Prosopagnosia Psychophysics Recovery Recovery of Function Recruitment Activity Relative (related person)Reporting Research Personnel Resolution Role Sampling Schizophrenia Semantics Shapes Specificity Stimulus Stream Syndrome Techniques Testing Tracer Variant Visual Visual Cortex Visual system structure area V1 base behavior test design face perception gaze human subject inferotemporal cortex information processing memory recognition microstimulation neural circuit neuromechanism novel novel strategies object perception programs relating to nervous system research study response visual object processing visual stimulus

项目摘要

DESCRIPTION (provided by applicant): At high levels of the primate visual system (e.g. those involved in visual object processing, in the 'ventral stream' including inferotemporal cortex), we do not fully understand the neural processing. Existing evidence is based largely on 1) single unit recordings from macaque monkey, or from 2) functional magnetic resonance imaging (fMRI) in humans. Because such evidence arises from quite different techniques, in different primates, with different historical backgrounds, it can be difficult to integrate this information into a coherent understanding of how visual objects are processed in brain. Such information is especially important for the eventual understanding of autism, prosopagnosia and other agnosias, and schizophrenia. Here we propose to use functional magnetic resonance imaging (fMRI) in both humans and macaque monkeys, and anatomical techniques in monkeys, to narrow this information gap and to define the common functional architecture of 'primate' ventral stream. Among many possible object stimuli, we focus on specialized neural regions which appear to process faces. In aim #1, we will use a novel fMRI approach to map the activity produced by faces (and other objects), in humans and monkeys, to test how specific stimulus variations are mapped across the cortical topography. Current fMRI information on this topic is instead based on responses to multiple stimuli (object categories) and/or adaptation effects - rather than direct, high-resolution maps of activity produced by individual stimuli. In aim #2, we quantitatively compare the fMRI maps for face- and object-selective activity in humans and monkeys, to further test which of these cortical regions 'match' each other in the two species, and which do not. After testing and confirming that these face- and object-selective regions 'match', we can study them further using classical neurobiological techniques in the macaque (e.g. aims #3 and 4), as a model for corresponding regions in humans. In aim #3, we will use novel MRI-based techniques to map the neural connections to-and-from the face-selective cortical regions, relative to nearby regions which are activated by different objects. In aim #4, we will measure face perception using psychophysics in monkeys, and make lesions in the fMRI-defined face-selective regions, to test whether damage to the face-selective regions may explain the clinical syndrome of prosopagnosia (facial 'blindness') in human patients.

描述（由申请人提供）：在灵长类视觉系统的高水平（例如，那些参与视觉对象处理的系统，在包括颞下皮层的“腹侧流”中），我们并不完全理解神经处理。现有证据主要基于 1) 猕猴的单个单位记录，或 2) 人类功能磁共振成像 (fMRI)。由于这些证据来自不同的灵长类动物、不同的历史背景的完全不同的技术，因此很难将这些信息整合到对视觉对象在大脑中如何处理的连贯理解中。这些信息对于最终了解自闭症、面部失认症和其他失认症以及精神分裂症尤其重要。在这里，我们建议在人类和猕猴中使用功能磁共振成像（fMRI），并在猴子中使用解剖技术，以缩小这一信息差距并定义“灵长类”腹侧流的共同功能架构。在许多可能的物体刺激中，我们关注似乎处理面部的专门神经区域。在目标#1中，我们将使用一种新颖的功能磁共振成像方法来绘制人类和猴子的面部（和其他物体）产生的活动，以测试特定的刺激变化如何在皮质地形上进行映射。目前有关该主题的功能磁共振成像信息是基于对多种刺激（对象类别）和/或适应效应的反应，而不是单个刺激产生的直接、高分辨率的活动图。在目标#2中，我们定量比较了人类和猴子的面部和物体选择性活动的功能磁共振成像图，以进一步测试这两个物种中哪些皮层区域相互“匹配”，哪些不匹配。在测试并确认这些面部和物体选择性区域“匹配”之后，我们可以使用猕猴的经典神经生物学技术（例如目标#3和4）进一步研究它们，作为人类相应区域的模型。在目标 3 中，我们将使用基于 MRI 的新型技术来映射面部选择性皮层区域与被不同物体激活的附近区域之间的神经连接。在目标#4中，我们将利用猴子的心理物理学来测量面部感知，并在功能磁共振成像定义的面部选择性区域中进行损伤，以测试面部选择性区域的损伤是否可以解释面部失认症的临床综合征（面部“失明”））在人类患者中。

项目成果

期刊论文数量（4）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

A parametric study of fear generalization to faces and non-face objects: relationship to discrimination thresholds.

对面部和非面部物体的恐惧泛化的参数研究：与歧视阈值的关系。

DOI：
发表时间：
2014
期刊：
影响因子：
0
作者：
Holt, Daphne J;Boeke, Emily A;Wolthusen, Rick P F;Nasr, Shahin;Milad, Mohammed R;Tootell, Roger B H
通讯作者：
Tootell, Roger B H

Smooth versus Textured Surfaces: Feature-Based Category Selectivity in Human Visual Cortex.

光滑表面与纹理表面：人类视觉皮层中基于特征的类别选择性。

DOI：
发表时间：
2016
期刊：
影响因子：
3.4
作者：
Echavarria, Cesar;Nasr, Shahin;Tootell, Roger
通讯作者：
Tootell, Roger

Curvature-processing network in macaque visual cortex.

猕猴视觉皮层的曲率处理网络。

DOI：
发表时间：
2014-08-19
期刊：
影响因子：
11.1
作者：
Yue, Xiaomin;Pourladian, Irene S;Tootell, Roger B H;Ungerleider, Leslie G
通讯作者：
Ungerleider, Leslie G

Supplemental Information Development of a MR-Visible Compound for Tracing Neuroanatomical Connections In Vivo

用于追踪体内神经解剖连接的 MR 可见化合物的补充信息开发

DOI：
10.21809/rilemtechlett.2017.39
发表时间：
2024-09-13
期刊：
Sensors and Actuators B-chemical
影响因子：
8.4
作者：
C. W. Wu;O. Vasalatiy;Ning Liu;Haitao Wu;S. Cheal;Der;A. Koretsky;G. Griffiths;R. Tootell;Leslie G. Ungerleider
通讯作者：
Leslie G. Ungerleider