Coils for Human Whole Body Imaging at 7T

用于 7T 人体全身成像的线圈

• 批准号: 8124733
• 负责人: John T Vaughan
• 金额: $ 9.99万
• 依托单位: LIFE SERVICES, LLC
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8124733
• 关键词: Acceleration; Attenuated; Biomedical Research; Body Image; Brain; Clinical; Coiled Bodies; Communities; Development; Diagnostic; Disease; Electric Capacitance; Elements; Engineering; Evaluation Reports; Frequencies; Funding; Goals; Head; Health; Heating; Human; Human body; Image; Life; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Manuals; Methods; Noise; Nuclear Magnetic Resonance; Pattern; Performance; Phase; Problem Solving; Radio; Research; Resolution; Resources; Running; Series; Signal Transduction; Simulate; Spectrum Analysis; Speed; System; Technology; Testing; Therapeutic Intervention; Time; TimeLine; Variant; Water; Writing; absorption; body system; commercialization; data acquisition; design; ergonomics; evaluation/testing; human tissue; innovation; instrument; magnetic field; neuroimaging; new technology; radiofrequency; tool; transmission process; whole body imaging

DESCRIPTION (provided by applicant): Currently in 40 luminary labs around the world, 7T MR is proving to be a powerful instrument for imaging the human brain. While the same potential exists for whole-body imaging at 7T, the radiofrequency coil technology and methods critical to realizing this potential have yet to be developed. In this proposal, we plan to solve this problem by developing the new technology and methods required. A progressive series of three new coils is proposed. The first coil solves problems of transmit field inefficiency and inhomogeneity for body imaging, with a close fitting, 16 channel TEM conformal array design with efficient shield capacitance decoupling. The second coil progresses directly from the first with automatic tuning and matching, an innovation of huge importance for multi-channel transmit coils. The third coil combines the second, auto- tuned multi-channel transmitter with a 32 channel receiver for best transmit efficiency, control, receive sensitivity and parallel imaging performance. This final coil will make safe, research grade, whole body imaging possible for the first time at 7T, with the inherent benefits of unprecedented SNR and imaging speeds. Phase II will pursue refinements and commercialization of this coil on Siemens, GE, and Philips 7T research and 3T clinical systems. PUBLIC HEALTH RELEVANCE: Currently in 40 luminary labs around the world, 7T MR is proving to be a powerful instrument for imaging the human brain. While the same potential exists for whole-body imaging at 7T, the radiofrequency coil technology and methods critical to realizing this potential have yet to be developed. This proposal has a progressive plan for developing the innovations required to transform 7T MRI into a powerful tool for whole- body imaging.

描述（由申请人提供）：目前，7T MR 在全球 40 个杰出实验室中被证明是一种强大的人脑成像仪器。虽然 7T 全身成像也存在同样的潜力，但实现这一潜力至关重要的射频线圈技术和方法尚未开发出来。在本提案中，我们计划通过开发所需的新技术和方法来解决这个问题。提出了三个新线圈的渐进系列。第一个线圈采用紧密贴合的 16 通道 TEM 共形阵列设计，具有高效的屏蔽电容去耦功能，解决了人体成像发射场效率低下和不均匀的问题。第二个线圈直接从第一个线圈开始，具有自动调谐和匹配功能，这对于多通道发射线圈来说是一项非常重要的创新。第三个线圈将第二个自动调谐多通道发射器与 32 通道接收器结合在一起，以实现最佳的发射效率、控制、接收灵敏度和并行成像性能。最终的线圈将首次在 7T 下实现安全的研究级全身成像，并具有前所未有的 SNR 和成像速度的固有优势。第二阶段将在西门子、GE 和飞利浦 7T 研究和 3T 临床系统上对该线圈进行改进和商业化。 公共健康相关性：目前，7T MR 在全球 40 个著名实验室中被证明是一种强大的人脑成像仪器。虽然 7T 全身成像也存在同样的潜力，但实现这一潜力至关重要的射频线圈技术和方法尚未开发出来。该提案制定了一项渐进计划，旨在开发将 7T MRI 转变为强大的全身成像工具所需的创新。