Bone cements for delivery of osteoinductive growth factors

用于输送骨诱导生长因子的骨水泥

• 批准号: 8196102
• 负责人: JONATHAN A HODGES
• 金额: $ 31.84万
• 依托单位: AFFINERGY ,INC
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8196102
• 关键词: Affinity; Animal Model; Animals; Area; Aspirate substance; Autologous; Binding; Biocompatible; Biological; Bone Cements; Bone Growth; Bone Marrow; Bone Morphogenetic Proteins; Bone Regeneration; Bone Transplantation; Calvaria; Cephalic; Clinical; Collagen; Collagen Type I; Complex; Defect; Dental; Diffusion; Equilibrium; Fracture; Growth Factor; Healed; Hydroxyapatites; Implant; In Situ; Injectable; Injection of therapeutic agent; Lead; Link; Liquid substance; Mechanics; Modeling; Morphology; Operative Surgical Procedures; Oral Surgical Procedures; Osteoblasts; Osteogenesis; Peptides; Phage Display; Phase; Phenotype; Powder dose form; Procedures; Property; Rattus; Research; Risk; Safety; Site; Tensile Strength; Testing; Time; bone; bone morphogenetic protein 2; bone morphogenetic protein 6; bone morphogenetic protein 7; calcium phosphate; healing; implantation; improved; inorganic phosphate; minimally invasive; novel; oral surgery specialty; osteogenic; osteoinductive factor; prototype; repaired; scaffold; standard of care; success; tetracalcium phosphate

DESCRIPTION (provided by applicant): Bone cements are widely used in maxillofacial surgery, repair of cranial defects, and dental fillings. Calcium phosphate bone cements are useful in many types of bone repair because they conform to the defect area, harden in situ, and can be resorbed and replaced by new bone. When the cements are injectable, they can also be used for minimally invasive surgery and filling narrow cavities and defects with limited accessibility. However, although calcium phosphate cements are biocompatible and set isothermally, they are only osteoconductive and do not possess osteoinductive properties. Attempts to augment the bioactivity of the material with growth factors have been limited by rapid diffusion of the growth factor away from the material. Therefore, there is a significant unmet clinical need for a bone cement that can retain and release osteoinductive factors at the site of healing. To that end, Affinergy has developed peptides with high affinities for osteoinductive growth factors. In this application, we propose to use our growth factor-binding peptides to capture autologous growth factors and deliver them with an injectable bone cement. In addition to oral and maxillofacial surgery, the final product could be modified for use in vertebroplasty, treatment of osteoporotic bones at risk of fracture, and minimally invasive repair of fresh fractures. PUBLIC HEALTH RELEVANCE: Bone cements support the growth of bone in a variety of procedures, but they lack the ability to induce bone growth. Growth factors can enhance bone formation but are limited by the lack of optimal carriers. In this application, we propose to test a novel bone cement as a carrier for growth factors.

描述（申请人提供）：骨水泥广泛应用于颌面外科、颅骨缺损修复和牙科填充。磷酸钙骨水泥可用于多种类型的骨修复，因为它们符合缺损区域，原位硬化，并且可以被新骨吸收和替代。当水泥可注射时，它们还可以用于微创手术以及填充狭窄的空腔和难以接近的缺陷。然而，尽管磷酸钙骨水泥具有生物相容性并等温凝固，但它们仅具有骨传导性，不具有骨诱导特性。用生长因子增强材料生物活性的尝试因生长因子从材料中快速扩散而受到限制。因此，对于能够在愈合部位保留和释放骨诱导因子的骨水泥存在显着的未满足的临床需求。为此，Affinergy 开发了对骨诱导生长因子具有高亲和力的肽。在此应用中，我们建议使用我们的生长因子结合肽来捕获自体生长因子并通过可注射骨水泥输送它们。除了口腔颌面外科手术之外，最终产品还可以进行修改，用于椎体成形术、治疗有骨折风险的骨质疏松性骨骼以及微创修复新鲜骨折。 公共健康相关性：骨水泥在各种手术中支持骨骼生长，但它们缺乏诱导骨骼生长的能力。生长因子可以增强骨形成，但由于缺乏最佳载体而受到限制。在此应用中，我们建议测试一种新型骨水泥作为生长因子的载体。