SIGNAL TRANSDUCTION

信号转导

• 批准号: 8473819
• 负责人: Ze'ev A Ronai
• 金额: $ 18.36万
• 依托单位: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8473819
• 关键词: Area; Biological Models; Caenorhabditis elegans; Cancer Biology; Cancer Center Support Grant; Cell Cycle; Cell Surface Receptors; Collaborations; Complement; DNA Damage; Development; Faculty; Fostering; Funding; Goals; Grant; Human; Hypoxia; Interest Group; Joints; Knockout Mice; Laboratories; Lead; Malignant Neoplasms; Mentors; Metabolic; Microscopy; Neoplastic Cell Transformation; Pathway interactions; Phenotype; Phosphorylation; Play; Post-Translational Protein Processing; Postdoctoral Fellow; Process; Productivity; Program Research Project Grants; Protein Biochemistry; Protein Dephosphorylation; Protein Kinase; Publications; Recruitment Activity; Role; Secure; Signal Repression; Signal Transduction; Signal Transduction Pathway; Stress; Transgenic Mice; Ubiquitin; Ubiquitin Like Proteins; Ubiquitination; base; cancer cell; cancer therapy; drug discovery; graduate student; insight; interest; meetings; member; mouse model; multidisciplinary; phosphatase-1 kinase; programs; therapeutic development; tool development; transcription factor; tumor; tumor progression; ubiquitin ligase

The overall goal of the Signal Transduction Program (STP) is to elucidate the mechanisms that govern activation and repression of signaling cascades during normal development, neoplastic transformation and tumor progression. This goal is based on the premise that abnormalities in signal transduction are universal features of human cancer cells, and underiie virtually all aspects of the transformed phenotype. Members of the Signal Transduction Program currently pursue three major investigative areas: (1) kinases and phosphatases that are important in tumor development and known to undergo changes in human tumors; (2) ubiquitin ligases and ubiquitin-like proteins that play important roles in cellular pathways that are deregulated during tumor development and progression; and (3) an emerging theme of altered metabolic signaling in cancer. The Signal Transduction Program was established in 2001, and has been greatly strengthened since the last renewal by recruitment of new faculty members with expertise that complements the interests of the original faculty members. Of the 16 current members, 11 members have been recruited since 2003. Among them is Dr. Ze'ev Ronai, who was recruited as new Program Leader for the Signal Transduction Program in 2004. The Program is highly collaborative and interactive as evidenced by joint laboratory meetings, joint mentoring of graduate students and postdoctoral fellows, joint mentoring program for young faculty, monthly postdoctoral fellow presentations, monthly faculty meetings, monthly interest group (ubiquitin, ER stress) meetings, the annual postdoctoral retreat, and several Program Project grant initiatives underway. As a result of these activities, Program members lead or participate in 4 POl grants (2 from NCI), in multiple shared federal and state grants, and multiple co-authored publications. The high productivity of the Program during the past grant period is further documented by 21 ROI grants (7 from NCI) held by the Program members; by the current total annual grant funding of $14.5MM ($8.2MM direct); by 392 publications since last review, and by 65 Program publications in 2008, which represent 11% of intra- and 31% of interprogrammatic collaborations, respectively.

信号转导计划（STP）的总体目标是阐明控制机制 在正常发育，肿瘤转化和 肿瘤进展。该目标基于以下前提：信号转导异常是通用的 人类癌细胞的特征，几乎没有转化表型的所有方面。成员 信号转导计划目前探讨三个主要的调查领域：（1）激酶和 在肿瘤发育中很重要且已知会发生人类肿瘤的变化的磷酸酶； （2） 泛素连接酶和泛素样蛋白在细胞途径中起重要作用的蛋白质 在肿瘤发育和进展过程中； （3）改变代谢信号的新兴主题 癌症。 信号转导程序于2001年建立，自上次以来已得到极大的加强 通过招募具有专业知识的新教职员工的续订，以补充原始的利益 教师。自2003年以来，在现有16名成员中，已有11名成员。其中是 Ze'ev Ronai博士，他于2004年被招募为信号转导计划的新计划负责人。 联合实验室会议，联合会议证明了该计划高度协作和互动性 指导研究生和博士后研究员，年轻教师的联合指导计划，每月 博士后研究员，每月教职会议，每月兴趣小组（Ubiquitin，ER压力） 会议，年度博士后务虚会以及正在进行的几项计划项目赠款计划。作为 这些活动的结果，计划成员领导或参与4个Pol赠款（来自NCI的2个），多个 共享联邦和州的赠款，以及多个共同作品的出版物。该计划的高生产率 在过去的赠款期间，该计划持有的21个ROI补助金（7）进一步记录了 成员；按目前的年度总授予资金14.5mm（直接$ 8.2mm）；从392个出版物开始 上次审查，以及2008年的65个计划出版物，占义工内部的11％和31％ 合作分别。