Cooperative Human Tissue Network (CHTN)

人体组织合作网络 (CHTN)

• 批准号: 8055425
• 负责人: LEONA W AYERS
• 金额: $ 88.91万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-01-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8055425
• 关键词: Academic Medical Centers; Advertising; Autopsy; Benign; Canada; Clinic; Collection; Communities; Computer software; Consent; Cooperative Human Tissue Network; Culture Media; Data; Diagnosis; Disease; Documentation; Formalin; Freezing; Fresh Tissue; Funding; Guidelines; Health Insurance Portability and Accountability Act; Human; Human Resources; Industry; Informed Consent; Leadership; Liquid substance; Mails; Malignant - descriptor; Malignant Neoplasms; Methods; Midwestern United States; National Cancer Institute; Nitrogen; Nucleic Acids; Ohio; Operative Surgical Procedures; Participant; Pathologist; Pathology; Patients; Process; Public Health; Quality Control; Research; Research Activity; Research Personnel; Saline; Services; Shipping; Ships; Specific qualifier value; Specimen; System; Time; Tissue Microarray; Tissues; Universities; anticancer research; base; human subject; improved; isopentane; meetings; member; research and development; tissue culture; tissue fixing

DESCRIPTION (provided by applicant): The Midwestern Division in the Department of Pathology at The Ohio State University Medical Center (OSUMC) will continue to operate as a productive, efficient, and valuable participant of the Cooperative Human Tissue Network (CHTN) for the National Cancer Institute (NCI). We will maintain a consortium procurement team that consists of OSUMC, Cleveland Clinic, and Case Western Reserve University. The Midwestern Division is the primary division for research investigators in the geographical north-midwest of the US as well as all of Canada. Our division will continue to provide human normal, diseased, benign, and malignant surgical and autopsy tissues, expand collections for fluids, and provide extended services for nucleic acid isolation and tissue microarray (TMA) construction from tissues. Remnant tissues obtained for the CHTN will be examined and selected grossly and quality controlled using histological review by a surgical pathologist. Tissues will be procured based on investigator-specified guidelines and shipped by express mail service. Typical methods of procurement include liquid nitrogen (LN2) snap frozen tissues, OCT medium frozen tissue in LN2 cooled isopentane, gauze-wrapped fresh tissues in cooled saline, fresh tissue in transport tissue culture medium with or without supplements, formalin, and gluteraldehyde fixed tissues. Investigator applications are prioritized according to the CHTN charter of NCI-funded academic, academic, industry researchers, respectively. The CHTN has common CHTN system-wide software to track investigator requests where changes made to each investigator's request are completed in real-time for accuracy in procurement. The Midwestern Division will conduct this research activity meeting the required HIPAA and human subjects' requirements, which may use a combination of anonymity, waived consent, and informed consent for the collection and use of specimens by CHTN investigators. The OSUMC information warehouse will also by used by the Midwestern Division to provide OSUMC patient-related disease associated data. The Midwestern Division will participate at every level of activity in the CHTN group by attending Coordinating Committee (CC) Meetings, serving on CC subcommittees, attend national scientific meetings and in regional venues to advertise the CHTN to the research public. We will continue to be a very active CHTN member contributing to the documentation and improvement of "best practices" for the research community, continue our membership in ISBER and other scientific venues to provide leadership ,in the arena of biospecimen collection, processing, storage, distribution, and research. Our efforts for the CHTN will aid public health by providing a consistent resource of human biospecimens for cancer research for the development of new information that will improve diagnosis and treatment for all cancers.

描述（由申请人提供）：俄亥俄州立大学医学中心 (OSUMC) 病理学系中西部分部将继续作为人体组织合作网络 (CHTN) 的富有成效、高效且有价值的参与者开展工作，癌症研究所（NCI）。我们将维持一个由 OSUMC、克利夫兰诊所和凯斯西储大学组成的联合采购团队。中西部分部是美国中北部地区以及加拿大全境研究人员的主要分部。我们的部门将继续提供人类正常、患病、良性和恶性的手术和尸检组织，扩大液体收集，并提供组织核酸分离和组织微阵列（TMA）构建的扩展服务。 CHTN 获得的残余组织将由外科病理学家进行粗略检查和选择，并使用组织学审查进行质量控制。组织将根据研究者指定的指南采购并通过特快专递服务运送。典型的获取方法包括液氮 (LN2) 速冻组织、LN2 冷却异戊烷中的 OCT 培养基冷冻组织、冷却盐水中纱布包裹的新鲜组织、含有或不含补充剂的运输组织培养基中的新鲜组织、福尔马林和戊二醛固定组织。研究者申请的优先顺序分别根据 NCI 资助的学术、学术和行业研究人员的 CHTN 章程进行。 CHTN 拥有通用的 CHTN 系统范围软件来跟踪调查员的请求，其中对每个调查员的请求所做的更改都是实时完成的，以确保采购的准确性。中西部部门将开展符合 HIPAA 要求和人类受试者要求的研究活动，CHTN 调查人员可能会结合使用匿名、放弃同意和知情同意来收集和使用样本。 OSUMC 信息仓库还将被中西部部门用来提供 OSUMC 患者相关疾病的相关数据。中西部分部将参与 CHTN 小组的各个级别的活动，包括参加协调委员会 (CC) 会议、在 CC 小组委员会任职、参加国家科学会议以及在地区性场所向研究公众宣传 CHTN。我们将继续成为非常活跃的 CHTN 成员，为研究界的“最佳实践”的记录和改进做出贡献，继续成为 ISBER 和其他科学场所的会员，在生物样本收集、处理、存储、分布、研究。我们对 CHTN 的努力将通过为癌症研究提供一致的人类生物样本资源来帮助公众健康，以开发新信息来改善所有癌症的诊断和治疗。