Cooperative Human Tissue Network

合作人体组织网络

基本信息

批准号：
7438674
负责人：
Wendy Frankel
金额：
$ 86.52万
依托单位：
OHIO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-06-01 至 2008-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7438674
关键词：
Academic Medical Centers Advertising Autopsy Benign Canada Clinic Collection Communities Computer software Consent Cooperative Human Tissue Network Culture Media Data Development Diagnosis Disease Documentation Facility Construction Funding Category Formalin Freezing Fresh Tissue Funding Guidelines Health Insurance Portability and Accountability Act Human Human Resources Industry Informed Consent Leadership Liquid substance Mails Maintenance Malignant - descriptor Malignant Neoplasms Methodology Methods National Cancer Institute Nitrogen Nucleic Acids Ohio Operative Surgical Procedures Participant Pathologist Pathology Patients Process Public Health Quality Control Research Research Activity Research Personnel Saline Services Shipping Ships Software Engineering Specific qualifier value Specimen System Testing Time TimeLine Tissue Microarray Tissues Universities anticancer research base design human subject human tissue improved isopentane member tissue culture

项目摘要

{\rtf1\ansi\ansicpg1252\deff0\deflang1033{\fonttbl{\f0\fswiss\fcharset0 Arial;}} {\*\generator Msftedit 5.41.15.1515;}\viewkind4\uc1\pard\f0\fs21 The Midwestern Division in the Department of Pathology at The Ohio State University Medical Center\par (OSUMC) will continue to operate as a productive, efficient, and valuable participant of the Cooperative\par Human Tissue Network (CHTN) for the National Cancer Institute (NCI). We will maintain a consortium\par procurement team that consists of OSUMC, Cleveland Clinic, and Case Western Reserve University. The\par Midwestern Division is the primary division for research investigators in the geographical north-midwest of\par the US as well as all of Canada. Our division will continue to provide human normal, diseased, benign, and\par malignant surgical and autopsy tissues, expand collections for fluids, and provide extended services for\par nucleic acid isolation and tissue microarray (TMA) construction from tissues. Remnant tissues obtained for\par the CHTN will be examined and selected grossly and quality controlled using histological review by a\par surgical pathologist. Tissues will be procured based on investigator-specified guidelines and shipped by\par express mail service. Typical methods of procurement include liquid nitrogen (LN2) snap frozen tissues,\par OCT medium frozen tissue in LN2 cooled isopentane, gauze-wrapped fresh tissues in cooled saline, fresh\par tissue in transport tissue culture medium with or without supplements, formalin, and gluteraldehyde fixed\par tissues. Investigator applications are prioritized according to the CHTN charter of NCI-funded academic,\par academic, industry researchers, respectively. The CHTN has common CHTN system-wide software to track\par investigator requests where changes made to each investigator's request are completed in real-time for\par accuracy in procurement. The Midwestern Division will conduct this research activity meeting the required\par HIPAA and human subjects' requirements, which may use a combination of anonymity, waived consent, and\par informed consent for the collection and use of specimens by CHTN investigators. The OSUMC information\par warehouse will also by used by the Midwestern Division to provide OSUMC patient-related disease\par associated data. The Midwestern Division will participate at every level of activity in the CHTN group by\par attending Coordinating Committee (CC) Meetings, serving on CC subcommittees, attend national scientific\par meetings and in regional venues to advertise the CHTN to the research public. We will continue to be a very\par active CHTN member contributing to the documentation and improvement of "best practices" for the\par research community, continue our membership in ISBER and other scientific venues to provide leadership ,in\par the arena of biospecimen collection, processing, storage, distribution, and research. Our efforts for the\par CHTN will aid public health by providing a consistent resource of human biospecimens for cancer research\par for the development of new information that will improve diagnosis and treatment for all cancers.\fs20\par \par }

{\rtf1\ansi\ansicpg1252\deff0\deflang1033{\fonttbl{\f0\fswiss\fcharset0 Arial;}} {\*\generator Msftedit 5.41.15.1515;}\viewkind4\uc1\pard\f0\fs21 俄亥俄州立大学医学中心病理科中西部分部\par （OSUMC）将继续作为合作社的富有成效、高效且有价值的参与者来运营美国国家癌症研究所 (NCI) 的人体组织网络 (CHTN)。我们将维持一个联盟\par 采购团队由 OSUMC、克利夫兰诊所和凯斯西储大学组成。的\par 中西部分部是美国中北部地理区域研究人员的主要分部美国以及整个加拿大。我们的部门将继续为人类提供正常的、患病的、良性的和\标准的恶性手术和尸检组织，扩大液体收集，并为\par提供扩展服务从组织中分离核酸和构建组织微阵列 (TMA)。获得的残余组织\par CHTN 将由 a\par 进行粗略检查和选择，并使用组织学审查进行质量控制外科病理学家。组织将根据研究者指定的指南采购并由\par运送特快专递服务。典型的采购方法包括液氮 (LN2) 速冻组织、\par OCT 介质冷冻组织在 LN2 冷却的异戊烷中，纱布包裹的新鲜组织在冷却的盐水中，新鲜\par 运输组织培养基中的组织，含或不含补充剂、福尔马林和戊二醛固定\标准组织。根据 NCI 资助的学术机构 CHTN 章程对研究者申请进行优先排序，\par 分别是学术界、工业界的研究人员。 CHTN 具有通用的 CHTN 系统范围软件来跟踪\标准调查员请求，其中对每个调查员的请求所做的更改都是实时完成的\par 采购的准确性。中西部分部将开展这项研究活动，以满足所需的\标准 HIPAA 和人类受试者的要求，可能会结合使用匿名、放弃同意和\par CHTN 调查人员收集和使用标本的知情同意书。 OSUMC 信息\par 仓库还将被中西部部门用来提供 OSUMC 患者相关疾病\par 相关数据。中西部赛区将参加 CHTN 小组的各个级别的活动出席协调委员会 (CC) 会议、在 CC 小组委员会任职、参加国家科学\标准会议和区域场所向研究公众宣传 CHTN。我们将继续成为一个非常\标准的积极的 CHTN 成员为“最佳实践”的记录和改进做出贡献\par 研究社区，继续我们在 ISBER 和其他科学场所的会员资格，以提供领导力，在\par 生物样本采集、处理、储存、分配和研究领域。我们为\par的努力 CHTN 将通过为癌症研究提供一致的人类生物样本资源来帮助公共卫生\par 开发新信息，改善所有癌症的诊断和治疗。\fs20\par \par }