Identifying and Measuring Depression in Older Cancer Patients

识别和测量老年癌症患者的抑郁症

• 批准号: 8550024
• 负责人: Christian J Nelson
• 金额: $ 17.8万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-24 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8550024
• 关键词: Address; Adverse effects; Age; Cancer Patient; Cancer Survivor; Cessation of life; Code; Country; DSM-IV; Data; Depressed mood; Depressive disorder; Desire for food; Deterioration; Diagnosis; Diagnostic; Diagnostic and Statistical Manual; Dysthymic Disorder; Economic Burden; Elderly; Fatigue; Feeling; Feeling hopeless; Guilt; High Prevalence; Individual; Interview; Link; Major Depressive Disorder; Malignant Neoplasms; Measurement; Measures; Mental Depression; Mental Health; Methods; Minor; Neurobehavioral Manifestations; Oncologist; Pain; Patient Self-Report; Patients; Pattern; Perception; Physical activity; Population; Prevalence; Process; Property; Psychiatrist; Psychologist; Psychometrics; Quality of life; Questionnaires; Reporting; Research; Sampling; Series; Sleep Disorders; Sleep disturbances; Source; Staging; Stomach; Symptoms; Testing; age group; base; cancer diagnosis; cost effective; depressive symptoms; experience; geriatric depression; geriatric mental health; instrument; interest; phrases; pleasure; programs; response; screening; theories; tool; young adult

DESCRIPTION (provided by applicant): The IOM Report states that by 2030, 20% of the population will be over 65. Currently, 60% of cancer diagnoses and 70% of deaths from cancer occur in this age group. Almost two-thirds of cancer survivors in this country are elderly and these percentages will continue to rise for the next 20 to 30 years. Depression is considered one of the top five concerns for the elderly and the prevalence of depressive disorders in older cancer patients ranges from 17-25%. Depression, throughout the spectrum from isolated depressive symptoms to major depressive disorder, is associated with decreased quality of life, deterioration in physical activities, relationship difficulties, caretaker burden, and greater pain. The economic burden of depression in the US has been estimated to be greater than 52 billion dollars a year. Yet, despite the high prevalence rates and deleterious effects of depression, elderly cancer patients are far less likely to be diagnosed with depression (major or minor) than any other age group. One reason for the underdiagnosis of depression in older cancer patients is that these patients may not report classic DSM-IV criteria. Self-report measures of depression are often an efficient and cost-effective way to identify depressive symptoms and make appropriate mental health referrals. However, there is a dearth of psychometric data establishing the validity of existing depression measurement tools in older cancer patients, and because these instruments are typically based on DSM criteria or classic symptoms of depression, it is unlikely that they can effectively assess depressive symptoms in this population. This proposal represents the first step in a program of research geared towards identifying, quantifying, and ultimately alleviating depression in older cancer patients, and will explore how older adults with cancer experience and express depressive symptomatology and develop a self-report scale tailored to this large, but under-recognized, population. The aims of this proposal are: 1) To identify the phenomenology of depression in older cancer patients, 2) To develop a set of indicators to identify depression in older cancer patients and operationalize these indicators in the form of questionnaire items, and 3) To evaluate the preliminary psychometric properties of a self-report measure of depression tailored to the needs of older cancer patients.

描述（由申请人提供）：IOM报告指出，到2030年，有20％的人口将超过65个。目前，该年龄段的癌症诊断中有60％和癌症死亡的70％发生。该国近三分之二的癌症幸存者是老年人，在接下来的20至30年中，这些百分比将继续上升。抑郁症被认为是老年癌症患者的老年人和抑郁症患病率的前五名之一，范围为17-25％。从孤立的抑郁症状到重大抑郁症的整个频谱中，抑郁症与生活质量下降，体育活动中的恶化，人际关系困难，看守负担和更大的疼痛有关。据估计，美国抑郁症的经济负担每年大于520亿美元。然而，尽管抑郁症的患病率高和有害影响，但老年癌症患者被诊断出患有抑郁症（主要或次要）的可能性要比任何其他年龄段都要少得多。老年癌症患者抑郁症诊断不足的原因之一是这些患者可能不会报告经典的DSM-IV标准。自我报告的抑郁量通常是识别抑郁症状并进行适当心理健康转诊的一种有效且具有成本效益的方式。但是，缺乏心理测量数据，确定了老年癌症患者现有抑郁症测量工具的有效性，并且由于这些仪器通常基于DSM标准或经典抑郁症状，因此他们不可能有效地评估该人群中的抑郁症状。该提案代表了一项旨在识别，量化和最终减轻癌症患者抑郁症的研究计划的第一步，并将探讨如何患有癌症经验和表达抑郁症状的老年人，并开发出针对这个大型但不足认识到的人群量身定制的自我报告量表。该提案的目的是：1）确定老年癌症患者抑郁症的现象学，2）开发一组指标，以确定老年癌症患者的抑郁症，并以问卷调查的形式进行这些指标，以及3）评估对年龄较大癌症患者需求的自我报告的初步心理测量特性。

项目成果

Individual meaning-centered psychotherapy for the treatment of psychological and existential distress: A randomized controlled trial in patients with advanced cancer.

• DOI: 10.1002/cncr.31539
• 发表时间: 2018-08-01
• 期刊: Cancer
• 影响因子: 6.2
• 作者: Breitbart W;Pessin H;Rosenfeld B;Applebaum AJ;Lichtenthal WG;Li Y;Saracino RM;Marziliano AM;Masterson M;Tobias K;Fenn N
• 通讯作者: Fenn N

Latent Profile Analyses of Depressive Symptoms in Younger and Older Oncology Patients.

• DOI: 10.1177/1073191118784653
• 发表时间: 2020-10
• 期刊: Assessment
• 影响因子: 3.8
• 作者: Saracino RM;Cham H;Rosenfeld B;J Nelson C
• 通讯作者: J Nelson C

Identification and treatment of depressive disorders in older adults with cancer.

老年癌症患者抑郁症的识别和治疗。

• DOI: 10.1016/j.jgo.2019.02.005
• 发表时间: 2019
• 期刊: Journal of geriatric oncology
• 影响因子: 3
• 作者: Saracino,RebeccaM;Nelson,ChristianJ
• 通讯作者: Nelson,ChristianJ

Performance of four diagnostic approaches to depression in adults with cancer.

成人癌症患者抑郁症的四种诊断方法的表现。

• DOI: 10.1016/j.genhosppsych.2018.01.006
• 发表时间: 2018
• 期刊: General hospital psychiatry
• 影响因子: 7
• 作者: Saracino,RebeccaM;Rosenfeld,Barry;Nelson,ChristianJ
• 通讯作者: Nelson,ChristianJ