Cognitive predictors of language impairment in Down syndrome
唐氏综合症语言障碍的认知预测因子
基本信息
- 批准号:8447529
- 负责人:
- 金额:$ 34.53万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-02-20 至 2015-01-31
- 项目状态:已结题
- 来源:
- 关键词:AdolescentAffectAgeAreaAwarenessBooksBrainChildCognitiveCommunicationComplexControl GroupsDevelopmentDown SyndromeEtiologyFutureGeneticHealthImpaired cognitionImpairmentIndividualInfantIntellectual functioning disabilityIntentionInterventionLanguageLanguage DelaysLanguage DevelopmentLeadLearningLifeLinkMeasuresMediationMemoryMemory impairmentMental RetardationModelingNatureParticipantPatternPersonsPopulationProcessRelative (related person)ResearchRoleSchoolsStructureSyndromeSystemTechniquesTelevisionTestingTimeVocabularyWorkage groupcomparativedesignexperiencegroup interventionlongitudinal designphonologysyntax
项目摘要
DESCRIPTION (provided by applicant): People with Down syndrome (DS) are usually in the lowest 2% of the population in intellectual ability, yet their language ability is far lower than their intellectual ability. Severe language limitations have a profound and pervasive impact on life functioning of people with DS. Though much work has been done to understand the pattern of language abilities in individuals with DS, little is known about the nature of the underlying processes or mechanisms that result in this pattern. The broad, long-term objective of the proposed research is to identify cognitive predictors of language impairment in DS, especially syntax. We predict that impairments in implicit learning and phonological memory together lead to impairments in language in this group. The study uses a combined comparative/longitudinal design in which a DS group, age 10-21, and 2 control groups (CA and mixed etiology ID) are tested at Time 1 and the DS and mixed ID groups are tested again 2 years later at Time 2. Specific Aim 1 is to demonstrate that, in addition to the known impairment in phonological memory, there is also a severe impairment in implicit learning in DS. We expect participants with DS to perform more poorly than CA and ID groups on measures of implicit learning and phonological memory. The study also includes a typical developmental trajectory to evaluate implicit learning in the DS and mixed ID groups. Specific Aim 2 is to demonstrate that implicit learning and phonological memory impairments are linked to language impairment in DS. If so, then (a) implicit learning and phonological memory will correlate with concurrent language ability in DS and (b) implicit learning and phonological memory at Time 1 will predict rate of language development over two years in DS. Specific Aim 3 is to test a partial mediation model of the influence of implicit learning on language in DS, especially syntax. We suggest that implicit learning affects language directly, because it limits the acquisition of complex rule systems and covariations necessary for language acquisition, but also indirectly, through phonological memory. Poor implicit learning of covariations among phonologic units in one's native language leads to limitations in phonological memory, which constrain language acquisition. We will test the partial mediation model concurrently and longitudinally over two years.
描述(申请人提供):唐氏综合症(DS)患者的智力通常处于人群中最低的2%,但他们的语言能力却远远低于智力。严重的语言限制对 DS 患者的生活功能产生深远而普遍的影响。尽管人们已经做了很多工作来了解 DS 患者的语言能力模式,但我们对导致这种模式的潜在过程或机制的性质知之甚少。本研究的广泛、长期目标是确定 DS 语言障碍的认知预测因素,尤其是语法障碍。我们预测,内隐学习和语音记忆的障碍共同导致该群体的语言障碍。该研究采用组合比较/纵向设计,其中 DS 组、年龄 10-21 岁和 2 个对照组(CA 和混合病因学 ID)在第 1 时间进行测试,DS 和混合 ID 组在 2 年后再次进行测试。时间2。具体目标1是证明,除了已知的语音记忆障碍外,DS中的内隐学习也存在严重障碍。我们预计患有 DS 的参与者在内隐学习和语音记忆方面的表现比 CA 和 ID 组更差。该研究还包括一个典型的发展轨迹,用于评估 DS 和混合 ID 组的内隐学习。具体目标 2 是证明内隐学习和语音记忆障碍与 DS 中的语言障碍有关。如果是这样,那么 (a) 内隐学习和语音记忆将与 DS 中的并发语言能力相关,(b) 时间 1 时的内隐学习和语音记忆将预测 DS 中两年内的语言发展速率。具体目标3是测试内隐学习对DS中语言(尤其是句法)影响的部分中介模型。我们认为内隐学习直接影响语言,因为它限制了语言习得所需的复杂规则系统和协变的习得,但也通过语音记忆间接影响语言。对母语语音单位之间的协变的内隐学习较差会导致语音记忆的限制,从而限制语言习得。我们将在两年内同时纵向地测试部分中介模型。
项目成果
期刊论文数量(9)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Family experience in a regional participant contact registry for research on intellectual disability.
智力障碍研究区域参与者联系登记处的家庭经验。
- DOI:10.1352/1934-9556-52.2.112
- 发表时间:2014
- 期刊:
- 影响因子:1.8
- 作者:Conners,FrancesA;Phillips,BAllyson;Rhodes,JenniferD;Hamilton,JamesC
- 通讯作者:Hamilton,JamesC
Verb production by individuals with Down syndrome during narration.
唐氏综合症患者在叙述过程中产生动词。
- DOI:10.1016/j.ridd.2018.11.007
- 发表时间:2019
- 期刊:
- 影响因子:3.1
- 作者:Loveall,SusanJ;Channell,MarieMoore;Abbeduto,Leonard;Conners,FrancesA
- 通讯作者:Conners,FrancesA
Rule-based category learning in Down syndrome.
唐氏综合症基于规则的类别学习。
- DOI:10.1352/1944-7558-119.3.220
- 发表时间:2014
- 期刊:
- 影响因子:0
- 作者:Phillips,BAllyson;Conners,FrancesA;Merrill,Edward;Klinger,MarkR
- 通讯作者:Klinger,MarkR
Visuo-spatial ability in individuals with Down syndrome: Is it really a strength?
- DOI:10.1016/j.ridd.2014.04.002
- 发表时间:2014-07-01
- 期刊:
- 影响因子:3.1
- 作者:Yang, Yingying;Conners, Frances A.;Merrill, Edward C.
- 通讯作者:Merrill, Edward C.
Addressing phonological memory in language therapy with clients who have Down syndrome: Perspectives of speech-language pathologists.
在唐氏综合症患者的语言治疗中解决语音记忆:言语病理学家的观点。
- DOI:10.1111/1460-6984.12241
- 发表时间:2016
- 期刊:
- 影响因子:2.4
- 作者:Faught,GayleG;Conners,FrancesA;Barber,AngelaB;Price,HannahR
- 通讯作者:Price,HannahR
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{{ truncateString('FRANCES A CONNERS', 18)}}的其他基金
Early cognitive decline in Down syndrome - Supplement
唐氏综合症的早期认知能力下降 - 补充
- 批准号:
10403731 - 财政年份:2020
- 资助金额:
$ 34.53万 - 项目类别:
Early Cognitive Decline in Down Syndrome – Neuroimaging Supplement
唐氏综合症的早期认知能力下降 – 神经影像补充品
- 批准号:
10670637 - 财政年份:2020
- 资助金额:
$ 34.53万 - 项目类别:
Role of Syntax in Reading Comprehension in Down Syndrome
语法在唐氏综合症阅读理解中的作用
- 批准号:
10475372 - 财政年份:2019
- 资助金额:
$ 34.53万 - 项目类别:
Cognitive predictors of language impairment in Down syndrome
唐氏综合症语言障碍的认知预测因子
- 批准号:
8215769 - 财政年份:2009
- 资助金额:
$ 34.53万 - 项目类别:
Cognitive predictors of language impairment in Down syndrome
唐氏综合症语言障碍的认知预测因子
- 批准号:
8043550 - 财政年份:2009
- 资助金额:
$ 34.53万 - 项目类别:
Cognitive predictors of language impairment in Down syndrome
唐氏综合症语言障碍的认知预测因子
- 批准号:
7775029 - 财政年份:2009
- 资助金额:
$ 34.53万 - 项目类别:
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