A Short Instrumented Test of Mobility for Neurological Disorders

神经系统疾病流动性的简短仪器测试

基本信息

批准号：
8446287
负责人：
FAY BAHLING HORAK
金额：
$ 34.13万
依托单位：
APDM, INC.
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-04-01 至 2014-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8446287
关键词：
Algorithms Basic Science Characteristics Chronic Clinical Clinical Protocols Computer software Craniocerebral Trauma Data Analyses Disease Elderly Environment Equilibrium Fall prevention Feedback Focus Groups Frail Elderly Future Gait Gait abnormality Goals Gold Graph Individual Instruction Kinetics Laboratories Laboratory Study Marketing Measures Metric Multiple Sclerosis Musculoskeletal Equilibrium Neurologic Neurologist Outcome Parkinson Disease Patients Performance Pharmaceutical Preparations Phase Preparation Procedures Protocols documentation Quality of life Recording of previous events Reporting Safety Sensitivity and Specificity Series Source Stroke System Technology Testing Time Translating User-Computer Interface Validity and Reliability Walking Wireless Technology Work balance testing base cost effective developmental disease disability equilibration disorder fall risk falls fear of falling innovation instrument kinematics mortality multisensory nervous system disorder novel research clinical testing response sensor standard measure tool

项目摘要

DESCRIPTION (provided by applicant): Poor balance is the most common source of mortality and reduced quality of life for the millions of people with chronic, neurological disease as well a many elderly people. No cost-effective, portable system is currently available to allow clinicians to objectively quantify postural stepping responses in a clinical environment. The long-term goal of our company, APDM, is to commercialize a state-of-the-art, clinical system to measure mobility disorders using our core technology: the world's most advanced wireless, synchronized, body-worn inertial sensors, the Opals (APDM.com). The objective of this Phase I application is to determine the feasibility of developing a very short balance and gait test related to fall risk using these sensors. The specific aims are: Aim I. To develop algorithms for automatic metrics and a composite 'Fall Risk score' from the Instrumented Stand and Walk Test (ISAW). The objective of Aim I is to develop and test the validity and reliability of a 1-minute balance and gait test for patients with Parkinson's disease. Aim II. To integrate the ISAW into the proprietary user-interface of the Mobility Lab system. The objective of Aim II is to build an innovative, computer user-interface that allows clinicians to quickly, accurately, safely and reliably test 3 aspects of postural control: sway during stance: postural sway, anticipatory postural adjustments, and dynamic balance during gait and turning in a short, 1-minute test. We will initially develop Mobility Lab for patients with Parkinson's disease because they have more falls than any other neurological disorder, but we are confident that this tool will be useful for physical therapists and clinicians and clinical trialists working with any form of mobility disability, such as multiple sclerosis, stroke, head injury, developmental disorders, multisensory deficits, frail elderly, etc. This Phase I application will determine the feasibility of the ISAW test. Our Phase II application will then determine how well the ISAW test predicts future falls, its sensitivity and specificity to mild neurological disease, responsiveness to medication, and safety of the ISAW for a wider range of neurological balance disorders and elderly fallers, in preparation for widespread marketing.

描述（由申请人提供）：平衡不良是数百万慢性神经系统疾病患者以及许多老年人死亡和生活质量下降的最常见原因。目前还没有经济高效的便携式系统可以让临床医生客观地量化临床环境中的姿势步进反应。我们公司 APDM 的长期目标是利用我们的核心技术将最先进的临床系统商业化，以测量行动障碍：世界上最先进的无线、同步、穿戴式惯性传感器 Opals （APDM.com）。第一阶段应用的目的是确定使用这些传感器开发与跌倒风险相关的非常短的平衡和步态测试的可行性。具体目标是：目标 I. 开发自动度量算法和仪表站立行走测试 (ISAW) 的综合“跌倒风险评分”。目标 I 的目标是开发和测试针对帕金森病患者的 1 分钟平衡和步态测试的有效性和可靠性。目标二。将 ISAW 集成到 Mobility Lab 系统的专有用户界面中。 Aim II 的目标是建立一个创新的计算机用户界面，使临床医生能够快速、准确、安全和可靠地测试姿势控制的 3 个方面：站立期间的摇摆：姿势摇摆、预期姿势调整以及步态和步态期间的动态平衡。进行简短的 1 分钟测试。我们最初将为帕金森病患者开发移动实验室，因为他们比任何其他神经系统疾病患者跌倒的次数都多，但我们相信，该工具将对处理任何形式的移动障碍的物理治疗师、临床医生和临床试验人员有用，例如多发性硬化症、中风、头部损伤、发育障碍、多感觉缺陷、年老体弱等。本次一期申请将确定ISAW测试的可行性。然后，我们的 II 期应用将确定 ISAW 测试预测未来跌倒的效果、其对轻度神经系统疾病的敏感性和特异性、对药物的反应性以及 ISAW 对于更广泛的神经平衡障碍和老年跌倒者的安全性，为广泛的神经系统平衡障碍和老年跌倒做好准备。营销。