Impact of Weight loss on Knee Joint Biochemical and Structural Degeneration

减肥对膝关节生化和结构退化的影响

基本信息

批准号：
9528275
负责人：
THOMAS M LINK
金额：
$ 31.78万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-08-01 至 2021-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9528275
关键词：
Address Affect Age Biochemical Biochemistry Biomechanics Body Weight Changes Body Weight decreased Bone Marrow Cartilage Cartilage Matrix Characteristics Clinical Clinical Trials Collagen Data Data Set Degenerative Disorder Degenerative polyarthritis Development Diagnostic radiologic examination Diet Disease Disease Progression Evolution Gait Gender Guidelines Health Heterogeneity Image Individual Inflammation Intervention Investigation Joints Knee Knee Osteoarthritis Knee joint Lead Longitudinal Studies Magnetic Resonance Imaging Measurement Mediating Meniscus structure of joint Methods Morphology Obesity Operative Surgical Procedures Outcome Measure Overweight Pain Participant Patients Pattern Physical Function Physical activity Prevalence Prevention Preventive treatment Public Health Questionnaires Recommendation Relaxation Risk Risk Factors SF-12 Stress Structure Symptoms T2 weighted imaging Techniques Time Treatment Efficacy Visit Water Weight Weight maintenance regimen Western Ontario and McMaster Universities Arthritis Index advanced disease base clinical practice cohort demographics design disorder prevention effective therapy follow-up imaging biomarker improved insight joint destruction joint loading knee pain modifiable risk muscle strength novel prevent public health relevance response temporal measurement

项目摘要

DESCRIPTION (provided by applicant): Obesity and osteoarthritis (OA) are intimately related; obesity is a modifiable risk factor for OA and weight loss may offer a potential non-invasive therapy for disease prevention and for slowing progression in obese individuals. To date, however, the effects of weight loss on joint structure and cartilage biochemistry, in particular in the early stages of disease, have been inconclusive; studies have been limited by short-term follow-up and have focused on advanced disease stages. The proposed study utilizes imaging data from the Osteoarthritis Initiative, which facilitates the assessment of early disease stages i conjunction with the longitudinal evolution of OA; using this unique and rich dataset, this study aims to determine the impact of weight loss on the biochemical and morphologic changes at the knee joint and their relationship with physical activity and clinical symptoms over a period of 8 years. We will use MRI T2 relaxation time measurements, which assess cartilage collagen integrity and water content as well as semi-quantitative morphological MR grading. We will comprehensively investigate the whole knee joint including the cartilage, meniscus, bone marrow, and joint space in subjects with weight loss and controls with constant weight over 8 years. Our proposed project has 3 Specific Aims: (I) To determine whether weight loss in overweight and obese individuals without OA (but risk factors for OA) as well as with OA protects against the development and progression of cartilage biochemical and morphological joint degeneration, and improves clinical symptoms over 8 years. (II) To determine which methods for weight loss (changes in diet, increased physical activity, surgery) are associated with slower progression of structural and biochemical joint degeneration as well as alleviation of clinical symptoms. (III) To identify baseline characteristics of patients whose weight loss is associated with slower progression of degenerative disease. The proposed project will, for the first time, assess whether weight loss in overweight and obese individuals may prevent the onset of OA and whether it may halt the progression of disease. By studying 640 subjects stratified by varied magnitudes of weight loss and varied levels of joint morphology, this proposal would comprehensively assess changes in joint morphology, cartilage biochemistry, and clinical symptoms in response to weight loss over 8 years. From this study, we expect to establish subject-specific guidelines for weight loss therapy in response to OA that are contingent upon the degree of pre-existing degenerative disease and initial weight. Prevention is currently the key intervention in OA and we strongly believe that our study will greatly contribute to streamlining and optimizing clinical practice of OA prevention

描述（由申请人提供）：肥胖和骨关节炎（OA）密切相关；肥胖是OA的可修改风险因素，体重减轻可能为预防疾病和肥胖个体的进展减缓提供潜在的非侵入性治疗。然而，迄今为止，减肥对关节结构和软骨生物化学的影响，特别是疾病的早期阶段尚无定论；研究受到短期随访的限制，并集中在晚期疾病阶段。拟议的研究利用了骨关节炎倡议的成像数据，该数据促进了对早期疾病阶段的评估，与OA的纵向进化相结合；使用这个独特且丰富的数据集，本研究旨在确定减肥对膝关节生化和形态变化的影响，以及它们在8年内与体育活动和临床症状的关系。我们将使用MRI T2松弛时间测量值，以评估软骨胶原完整性和水含量以及半定量形态学MR分级。我们将全面研究整个膝关节，包括软骨，半月板，骨髓和关节空间，这些受试者的体重减轻和控制持续8年的控制。我们提出的项目具有3个具体目标：（i）确定没有OA的超重和肥胖个体的体重减轻（但OA的危险因素）以及OA是否可以防止软骨生化和形态关节变性的发展和进展，以及在8年内改善临床症状。（ii）确定体重减轻的方法（饮食变化，体育锻炼，手术增加）与结构和生化关节变性的进展较慢以及减轻临床症状有关。（iii）确定体重减轻与退行性疾病进展较慢有关的患者的基线特征。拟议的项目将首次评估超重和肥胖个体的体重减轻是否可能阻止OA的发作以及它是否可以阻止疾病的进展。通过研究640名受试者，通过体重减轻的不同和不同水平的关节形态分层，该建议将全面评估关节形态，软骨生物化学和临床症状的变化，以应对8年的体重减轻。从这项研究中，我们期望建立特定于主体的减肥疗法指南，以应对OA，这取决于先前存在的退行性疾病和初始体重的程度。预防目前是OA的关键干预措施，我们坚信我们的研究将极大地做出贡献简化和优化预防OA的临床实践

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Diagnostic Performance of CT-Guided Bone Biopsies in Patients with Suspected Osteomyelitis of the Appendicular and Axial Skeleton with a Focus on Clinical and Technical Factors Associated with Positive Microbiology Culture Results.

CT 引导下骨活检对疑似附肢和中轴骨骼骨髓炎患者的诊断性能，重点关注与微生物培养阳性结果相关的临床和技术因素。

DOI：
10.1016/j.jvir.2019.08.013
发表时间：
2020
期刊：
Journal of vascular and interventional radiology : JVIR
影响因子：
0
作者：
Schirò,Silvia;Foreman,SarahC;Bucknor,Matthew;Chin,CynthiaT;Joseph,GabbyB;Link,ThomasM
通讯作者：
Link,ThomasM

Imaging of Osteoarthritis in Geriatric Patients.

老年患者骨关节炎的影像学。