T2 Relaxation Time of Knee Cartilage in the OAI Incidence Subcohort

OAI 发病亚组中膝关节软骨的 T2 松弛时间

• 批准号: 7924331
• 负责人: THOMAS M LINK
• 金额: $ 21.77万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7924331
• 关键词: Age; Anatomy; Biological Markers; Body mass index; Bone Density; Bone Marrow; Cartilage; Cartilage Matrix; Clinical; Data Analyses; Degenerative polyarthritis; Development; Diagnosis; Disease; Elderly; Evolution; Heterogeneity; High Prevalence; Imaging Techniques; Incidence; Instruction; Joints; Knee; Knee Injuries; Knee joint; Knowledge; Lesion; Life Style; Link; Longitudinal Studies; Magnetic Resonance Imaging; Maps; Measurement; Measures; Meniscus structure of joint; Methods; Organ; Outcome; Outcome Measure; Pain; Patients; Performance; Physical activity; Physical activity scale; Prevalence; Preventive; Principal Investigator; Recruitment Activity; Relaxation; Risk; Role; Staging; Symptoms; Texture; Time; Width; aged; base; clinical application; cohort; disability; improved; indexing; muscle strength; osteoporosis with pathological fracture; performance tests; prevent

DESCRIPTION (provided by applicant): This study will thoroughly investigate the potential role and significance of cartilage T2 relaxation time as a potential outcome marker for early osteoarthritis. It will focus on asymptomatic (according to WOMAC pain score) subjects of the incidence cohort of the OAI with varying degrees of physical activity, who are at increased risk for osteoarthritis. A number of these subjects will eventually develop osteoarthritis over the course of this 48 months longitudinal study and the proposed data analysis will provide unique information on the evolution of MR based biomarkers in this cohort. The specific aims are (I) to assess prevalence of cartilage, meniscal and ligamentous lesions in subjects from the incidence cohort of the OAI aged 45-60 years without pain using the whole organ magnetic resonance imaging score (WORI\/IS) in relation to physical activity determined by the physical activity scale for the elderly (RASE) and physical performance tests, (II) to measure cartilage T2 of all joint compartments combined and separately and correlate these quantitative measurements with prevalence and grade of focal cartilage, meniscal, ligamentous and bone marrow lesions as well as measurements of physical activity and physical performance, (IIIA) to analyze whether baseline T2 values will predict focal lesion progression diagnosed with H/OR/WS, clinical changes in KOOS (Knee Injury and Osteoarthritis Outcome Score) indices and eventually changes in PASE after 24 and 48 months and (IIIB) to longitudinally assess changes in T2 values, radiographic findings and focal joint lesions diagnosed with morphological MR sequences (WORMS) in relation to changes of pain scales, PASE and physical performance over a period of 48 months. The study will be performed in 300 subjects recruited from the incidence cohort of the OAI with no pain based on WOMAC scores, age 45-60 years and normal body mass index at baseline. Semiquantitative and quantitative MR imaging parameters will be analyzed in relation to clinical findings over a period of 4 years. We strongly believe, that the advances in knowledge that we gain through this study will help us better understand the role of T2 values in OA in relation to the evolution of OA and will help in focusing our preventive efforts on the earliest disease stages. This study may also provide evidence on life style factors that may be modified to prevent the development of osteoarthritis. RELEVANCE (See instructions): The combined analyses of morphological and quantitative MR imaging findings in relation to clinical findings will help us better understand the evolution of osteoarthritis at its earliest stages. Assessing cartilage matrix quality determined with T2 measurements may potentially gain a similar role in predicting risk of osteoarthritis such as bone mineral density currently has in predicting osteoporotic fractures. This longitudinal study performed in patients from the incidence cohort of the OAI will for the first time provide evidence whether cartilage T2 can predict development of OA, study MR findings associated with the evolution of OA and potentially give evidence on how long-term to prevent osteoarthritis and disability.

描述（由申请人提供）：本研究将彻底研究软骨T2松弛时间的潜在作用和意义，这是早期骨关节炎的潜在结果标志物。它将集中在OAI发生的无症状（根据WOMAC疼痛评分）和不同程度的体育活动中，他们患骨关节炎的风险增加。在这48个月的纵向研究过程中，这些受试者中的许多最终将出现骨关节炎，而拟议的数据分析将提供有关该队列中MR基于MR的生物标志物进化的独特信息。具体目的是（i）评估来自45 - 60岁OAI年龄较高的OAI队列的受试者的软骨，半月板和韧带病变的患病率，而无需使用整个器官磁共振成像（WORII \/IS），而没有疼痛。体育活动由老年人（RASE）和身体表现测试的体育锻炼量表确定，（ii）测量所有联合室的软骨T2，并分别结合并将这些定量测量与焦点，半月板，薄膜，韧带和韧带和韧带和韧带，韧带和型号相关联骨髓病变以及体育锻炼和身体性能的测量，（IIIA）分析基线T2值是否会预测诊断为H/OR/WS的局灶性病变进展，KOOS的临床变化（膝关节损伤和骨关节炎结果评分）和指标分数）和指数分数）和指数。最终在24个月和48个月后的PASE变化，以及（IIIB），以纵向评估T2值的变化，射线照相发现和焦点关节病变，这些变化诊断为疼痛，Pase和身体性能的变化，诊断为形态学MR序列（WORMS） 48个月。这项研究将在OAI的发病率队列中招募的300名受试者中进行，但基于WOMAC评分，年龄为45-60岁，基线时体重指数正常。在4年内，将分析半定量和定量MR成像参数。我们坚信，通过这项研究获得的知识进步将有助于我们更好地理解T2值在OA中与OA演变有关的作用，并将有助于将我们的预防努力集中在最早的疾病阶段。这项研究还可能提供有关生活方式因素的证据，这些因素可能会被修改以防止骨关节炎的发展。 相关性（请参阅说明）：与临床发现有关的形态和定量MR成像发现的综合分析将有助于我们更好地了解骨关节炎的最早阶段的演变。评估用T2测量确定的软骨基质质量，可能在预测骨关节炎的风险中可能具有相似的作用，例如目前在预测骨质疏松性骨折方面具有类似的骨矿物质密度。对OAI发病率的患者进行的这项纵向研究将首次提供证据，这证据了软骨T2是否可以预测OA的发展，研究与OA演变相关的MR调查结果，并有可能提供有关如何预防骨关节炎的长期证据。和残疾。