High-Bandwidth Wireless Interfaces for Continuous Human Intracortical Recording

用于连续人体皮质内记录的高带宽无线接口

基本信息

批准号：
9148086
负责人：
LEIGH R HOCHBERG
金额：
$ 202.05万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-30 至 2022-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9148086
关键词：
Achievement Amyotrophic Lateral Sclerosis Base of the Brain Biological Brain Stem Infarctions Caregivers Cervical spinal cord injury Chronic Clinical Clinical Engineering Clinical Research Clinical Trials Communication Complex Computers Data Development Devices Disease Employment Opportunities Engineering Environment Evolution Feasibility Studies Future Goals Hand Hand functions Health Care Costs Health Personnel Home environment Hour Human Implant Individual Intuition Investigation Lead Libraries Limb Prosthesis Limb structure Locked-In Syndrome Medical Device Movement Nervous System Trauma Neurodegenerative Disorders Neurology Neurons Neurosciences Paralysed Participant Physically Handicapped Quadriplegia Quality of life Recovery Research Robotics Role Safety Signal Transduction Site Source Speech Supervision System Technology Testing Thinking Time Validation Wireless Technology arm brain cell brain computer interface commercialization communication device experience first-in-human flexibility functional electrical stimulation improved infection risk insight limb movement medical implant meter motor control motor learning nervous system disorder neural implant neuromuscular stimulator neuroprosthesis neuropsychiatric disorder neurosurgery neurotechnology neurotransmission next generation novel pre-clinical prototype public health relevance relating to nervous system research clinical testing symptom management terabyte therapy design

项目摘要

DESCRIPTION (provided by applicant): Neurologic disorders including cervical spinal cord injury, brainstem stroke, and amyotrophic lateral sclerosis can lead to severe paralysis of all fou limbs. More than 100,000 people in the US have tetraplegia from these and other disorders, which in their most extreme forms can lead to loss of all voluntary movement and the loss of speech (locked-in syndrome). Over the past 10 years, intracortically based brain-computer interfaces have been developed with the hope of restoring voluntary, intuitive, flexible, and around-the-clock control of external devices such as a computer cursor, or internal neuromuscular stimulators capable of reanimating limb movement. In humans, conveying these powerful, high-bandwidth, intracranially recorded neural signals to external neural decoders has required percutaneous components that tether the user to nearby technologies and require regular caregiver assistance to reduce the risk of infection. We have created and performed initial nonclinical testing of a fully implanted, high bandwidth neural recording system that can transmit 100 channels of neuronal ensemble data to receivers up to 1 meter away. This tightly collaborative, multi-institutional project brings together leaders in neurology, neurosurgery, neuroscience, neuroengineering, and medical device clinical trials to (1) complete the manufacture and regulatory assessment of this next- generation technology, and (2) perform a rigorous Early Feasibility Study in which six participants with tetraplegia will test the investigational BrainGate3 Neural Interface System, at home, for at least one year. This study will provide early clinical experience with a novel neurotechnology platform, and will inform the development of next-generation closed-loop neural recording and stimulating devices to help manage the symptoms of neurologic and neuropsychiatric disease.

描述（由申请人提供）：包括颈脊髓损伤、脑干中风和肌萎缩侧索硬化症在内的神经系统疾病可导致四肢严重瘫痪，在美国有超过 100,000 人因这些疾病和其他疾病而出现四肢瘫痪。最极端的形式可导致所有自主运动的丧失和言语的丧失（锁定综合症），在过去的 10 年中，以皮质内为基础。脑机接口的开发是为了恢复对外部设备的自愿、直观、灵活和全天候的控制，例如计算机光标或能够恢复人类肢体运动的内部神经肌肉刺激器，传达这些强大的功能。，高带宽、颅内记录的神经信号发送到外部神经解码器需要经皮组件，将用户与附近的技术联系起来，并且需要定期护理人员的帮助以降低感染的风险。创建并执行了对完全植入的高带宽神经记录系统的初步非临床测试，该系统可以将 100 个通道的神经集合数据传输到 1 米外的接收器。这个紧密合作的多机构项目汇集了神经病学、神经外科和神经科学领域的领导者。、神经工程和医疗设备临床试验，以 (1) 完成这一下一代技术的制造和监管评估，以及 (2) 进行严格的早期可行性研究，其中六名四肢瘫痪的参与者将测试研究性 BrainGate3 神经接口系统，在家里进行至少一年，这项研究将提供新型神经平台技术的早期临床经验，并将为下一代闭环神经记录和刺激设备的开发提供信息，以帮助管理症状。神经系统和神经精神疾病。